E-ISSN:2456-3110

Research Article

Udavartini Yonivyapada

Journal of Ayurveda and Integrated Medical Sciences

2022 Volume 7 Number 1 Jan-Feb
Publisherwww.maharshicharaka.in

Randomized controlled clinical study of Rajpravartini Vati along with Koshn Jala in Udavartini Yonivyapada

G. Tamkhane V.1*, K. Agawane U.2, A. Patil V.3
DOI: http://dx.doi.org/10.21760/jaims.7.1.4

1* Vaishali G. Tamkhane, Post Graduate Scholar, Dept. of Stree Rog & Prasuti Tantra, Government Ayurvedic College, Osmanabad, Maharashtra, India.

2 Umesh K. Agawane, Assistant Professor, Dept. of Stree Rog & Prasuti Tantra, Government Ayurvedic College, Osmanabad, Maharashtra, India.

3 Veena A. Patil, Prof. & HOD, Dept. of Stree Rog & Prasuti Tantra, Government Ayurvedic College, Osmanabad, Maharashtra, India.

Udavartini Yonivyapada can be compared with the primary dysmenorrhea. Dysmenorrhea itself is not life threatening, but is found to have a profound impact on the daily activities and it may emphasize the emotional distress brought on by the pain. The treatment of this disorder is still unsatisfactory in modern medicine as usual of Non-steroidal anti-inflammatory drugs, anti-spasmodic, steroid contraceptive pills etc. That causes so many side effects. The present study is aimed to observe efficacy of Rajahpravartini Vati in Udavartini Yonivyapada mentioned in Bhaishjya Ratnavali. Study was conducted on 80 patients, 40 patients each in trial group and control group respectively. Clinical assessment was done on basis of grading criteria with specific symptomology of Udavartini Yonivyapada. The results were statistically and clinically significant to relieve symptoms of Udavartini Vyapada.

Keywords: Udavartini, Yonivyapada, Rajahpravartini Vati, Koshn Jala, Dysmenorrhoea

Corresponding Author How to Cite this Article To Browse
Vaishali G. Tamkhane, Post Graduate Scholar, Dept. of Stree Rog & Prasuti Tantra, Government Ayurvedic College, Osmanabad, Maharashtra, India.
Email: 		Vaishali G. Tamkhane, Umesh K. Agawane, Veena A. Patil, Randomized controlled clinical study of Rajpravartini Vati along with Koshn Jala in Udavartini Yonivyapada. J Ayu Int Med Sci. 2022;7(1):25-28.
Available From
https://jaims.in/jaims/article/view/1715

Manuscript Received Review Round 1 Review Round 2 Review Round 3 Accepted
2022-01-27 2022-01-29 2022-02-05 2022-02-12 2022-02-19
Conflict of Interest Funding Ethical Approval Plagiarism X-checker Note
Nil Nil Yes 17%

© 2022by Vaishali G. Tamkhane, Umesh K. Agawane, Veena A. Patiland Published by Maharshi Charaka Ayurveda Organization. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License https://creativecommons.org/licenses/by/4.0/ unported [CC BY 4.0].

Journal of Ayurveda and Integrated Medical Sciences 2022;7(1)25
Tamkhane V. et al: Randomized controlled clinical study of Rajpravartini Vati

Introduction

Udavartini Yonivyapada can be compared with the primary dysmenorrhea. Acharya Charaka has mentioned that Yoniroga can’t occur without vitiation of Vata. Again, pain is the main feature of Kashtartava, so it has strong relation with Vata.[3] In the classical text it is explained that due to Vega Dharana of Vata, Mutra, Purisha the Apana Vata gets vitiated and it get Urdhvgami i.e., normal Anulomaka Gati of Apana Vayu changes to Pratilome Gati and this vitiated Vata lift the Yoni upward and causes obstruction to flow of Raja and Raja comes out with great difficulty with severe Shoola.[4]

Dysmenorrhea is defined as the presence of painful cramps of lower abdomen causes during menstruation, there for that woman are often incapacitate from daily activities for one or more days in each period.[5] The prevalence of dysmenorrhoea 70.2%.[6]

Rajahpravartini Vati along with Koshn Jala has Vatanulomaka, Vedanashamaka, decrease of Rajoh-Avrodha, Shoolahara, relieving obstruction in tract and spasm.[7]

Rajahpravartini Vati with Koshn Jala has great effect in Udavartini Yonivyapada.

Aim

Study the role of Rajpravartini Vati in Udavartini Yonivyapada w.s.r.  to Primary Dysmenorrhoea.

Objectives

  1. To evaluate the efficacy of Rajpravartini Vati in Udavartini Yonivyapada in detail.
  2. To compare efficacy of Rajpravartini Vati and Tab spas 500mg in Udavartini Yonivyapada.
  3. To study Udavartini Yonivyapada, Primary Dysmenorrhea, Rajpravartini Vati and Tab Meftal Spas in detail.

Materials and Methods

Materials

All material available Ayurvedic books and modern text, articles, journals, Internet research paper were referred for the study.

Sample size - 40 each group

Selection of patients - From the Streerog and Prasutitantra O.P.D.

Group A - 40 patients with Rajahpravartini Vati

Group B - 40 patients with Tab Meftal spas 500mg

Trial Drug - Rajpravartini Vati purchased from standard Ayurvedic market preparation.

Duration of study - 3 consecutive menstrual cycle

Follow up - Assessment on 4th day of 3 consecutive cycles

Group of patients

  1. Group A - Trial group

Number of patients - 40

Drug - Rajahpravartinivati

Dose - 250mg 2BD before meal with Koshn Jala

Duration of treatment - 21st day of menstrual cycle for 10 days for 3 consecutive cycle


  1. Group B - Control group

Number of patients - 40

Drug - Tab Meftal spas

Dose - 500mg BD after meal

Duration of Treatment - from 1st day of menstrual cycle for 3 days for 3 consecutive cycle

Inclusion criteria

  • Age 14-25 years
  • Hb >10 gm %
  • Primary dysmenorrhoea
  • Painful menstruation at least for 2 consecutive menstrual cycle

Exclusion criteria

  • Major systemic disease
  • congenital anomaly
  • Pelvic pathology on hormonal therapy

Criteria for assessment

SN Symptoms Score
1. Menstruation is not painful, daily activity is unaffected 0
2. Menstruation is painful, daily activity is unaffected. 1
3. Menstruation is painful, daily activity is affected. 2
4. Menstruation is so painful unable to do even the routine work 3

Journal of Ayurveda and Integrated Medical Sciences 2022;7(1)26
Tamkhane V. et al: Randomized controlled clinical study of Rajpravartini Vati

Pain: Severity of pain (multi-dimensional scoring pattern.)

Duration of Pain

SN Symptoms Score
1. No pain during menstruation 0
2. Pain persists for less than 12 hrs. 1
3. Pain persists for 12-24 hrs. 2
4. Pain persists for more than 24 hrs. 3

Associated Symptoms

  • Nausea

0 - No Nausea

1 - 2-3 times/day

2 - 4-5 times/day

3 - More than 5 times/day


  • Vomiting

0 - No Vomiting

1 - Occasionally

2 - 1-2 times/day

3 - More than 2 times/day


  • Fatigue

0 - No fatigue

1 - Fatigue by normal daily routine

2 - Fatigue induced by having even single extra work in addition to the daily routine.

3 - Severe fatigue even without work


  • Headache

0 - No headache

1 - Headache once during each menstruation; persists for less than 6 hrs.

2 - Frequent headache 2-3 times per menstruation; daily activity not affected.

3 - Persistent headache throughout the menstruation; daily activity affected.

Investigations

Hb%

USG if needed

According to % Relief in Symptoms

Table 1: % Relief in Symptoms of both groups

SN Symptoms   % Relief
Group A Group B
1. Severity of pain 80.00 68.83
2. Duration of pain 79.03 71.15
3. Nausea 78.26 71.43
4. Vomiting 83.33 72.22
5. Fatigue 84.62 63.33
6. Headache 76.92 75.00
7. Avg. % Relief 80.36 70.33

Discussion

Rajoh Avrodh is the mainly responsible for Udavartini Yonivyapada. Vata Dosha, Apan Vayu Pratiloman is main route of cause of Rajah Avrodh.

Rajahpravartini Vati contains Hingu, Tankan, Kasisa, Kanyasara are Vata-Kapha Shamaka, Vatanuloka, Vedanashamaka, Shoolahara and relieving Rajoh Avrodh.

By applying Mann Whitney’s U test, value of p being <0.05, it was concluded that Rajpravartini Vati is significantly effective than Tab Meftal spas to reduce Severity of pain, Duration of pain, fatigue (subjective criteria) in Uadavartini Yonivyapada.

Also, for other subjective parameters, p value is >0.05, therefore it can be concluded that there is no significant difference between efficacy of Rajpravartini Vati and Tab Meftal Spas to reduce associated symptoms like Nausea, Vomiting, Headache.

Statistical analysis after study it is shows that Rajahpravartini Vati is more effective in comparison to Tab Meftal Spas in Udavartini Yonivyapada (primary dysmenorrhea).

Conclusion

Significant difference was seen in parameters like Severity of pain, duration of pain, fatigue, which is clear that Trial drug is more effective than control drug. No Significant difference was seen in other assessment parameters which concludes similar efficacy of both groups.

Percentage relief in symptoms in Group A was 80.36% and 70.33% in Group B. Comparing to this two-group concluded that trial group (Rajpravartini Vati) was significantly better than control group (Tab Meftal Spas).


Journal of Ayurveda and Integrated Medical Sciences 2022;7(1)27
Tamkhane V. et al: Randomized controlled clinical study of Rajpravartini Vati

Reference

  1. Dr Nidhi Garg and Dr Anjali Jain, Ayurvedic perspective of Kashtartava, International Journal of current research, Jan2017.
  2. Kaviraj Govind Das Sen, Bhaishajya Ratnavali 2017, Varanasi, Chaukhamba Surbharti Prakashan, Yonivyapada Rogadhikar, p-1046.
  3. Agnivesha, 2004, Charaka Samhita, eds R.K. Sharma, Bhagwan Das, Chowkhamba Sanskrit series, office, Varanasi. Vol.5, page36.
  4. Charak Samhita of Agnivesha vol. 2 Chikitsa Sthana, chapter30, shlok 25,26; edition by Acharya Vidyadhar Shukla and Prof. Ravi Dutt Tripathi, Choukhamba Sanskrit Pratisthana, Delhi, 2007, page 757.
  5. Zeev Harel. Dysmenorrhoea in Adolescents and young adults. Etiology and Management, Journal of pediatric and adolescent gynecology, Vol.19, Issue 6, Dec 2006; Elsevier Inc, p363-371.
  6. Dutta D.C. Text book of Gynecology. New Central Book Agency (p) LTD Kolkata, edition 4, reprint 2007; chapter 12; 168.
  7. Kaviraj Govind Das Sen, Bhaishajya Ratnavali 2017, Varanasi, Chaukhamba Surbharti Prakashan, Yonivyapada Rogadhikar, p-1046.

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