E-ISSN:2456-3110

Research Article

Guduchyadi Malahara

Journal of Ayurveda and Integrated Medical Sciences

2023 Volume 8 Number 3 March
Publisherwww.maharshicharaka.in

Pharmaceutical comparative study of Guduchyadi Malahara (ointment), prepared by different methods in the management of Kaphaja Yoni Vyapat

Singh S.1*, Prathima.2, Gayathri Bhat N.3, Sharma G.4
DOI: http://dx.doi.org/10.21760/jaims.8.3.7

1* Smriti Singh, Assistant Professor, Department of Prasuti Tantra and Stree Roga, Doon Ayurvedic Medical College and Hospital, Saharanpur, Uttar Pradesh, India.

2 Prathima, Professor and HOD, Department of Prasuti Tantra and Stree Roga, Sri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital, Hassan, Karnataka, India.

3 N.V. Gayathri Bhat, Professor, Department of Prasuti Tantra and Stree Roga, Sri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital, Hassan, Karnataka, India.

4 Govind Sharma, Professor and Teaching Pharmacy Incharge, Department of Rasa Shastra and Bhaishajya Kalpana, Sri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital, Hassan, Karnataka, India.

Malahara is one among the Kalpana of preparation of ointment. Siktha (bee wax) and Taila (oil) are usually taken as base along with other ingredients like herbal, mineral or metal depending upon the indication and type of Malahara.[1] Present study focuses on modification of Guduchyadi Kashaya[2] into Guduchyadi Malahara form. This formulation has been indicated for treatment of Kaphaja Yoni Vyapat.[3] Kashaya having less shelf life; hence, an attempt has been made to modify Guduchyadi Kashaya into Guduchyadi Malahara form pharmaceutically. The observations made during preparation and application of the Guduchyadi Malahara have been discussed in this study.

Keywords: Guduchyadi Malahara, Kalpana, Kaphaja Yoni Vyapat, Bahiparimarjana, Kandughna, Jantughna

Corresponding Author How to Cite this Article To Browse
Smriti Singh, Assistant Professor, Department of Prasuti Tantra and Stree Roga, Doon Ayurvedic Medical College and Hospital, Saharanpur, Uttar Pradesh, India.
Email: 		Smriti Singh, Prathima, N.V. Gayathri Bhat, Govind Sharma, Pharmaceutical comparative study of Guduchyadi Malahara (ointment), prepared by different methods in the management of Kaphaja Yoni Vyapat. J Ayu Int Med Sci. 2023;8(3):42-45.
Available From
https://jaims.in/jaims/article/view/2334

Manuscript Received Review Round 1 Review Round 2 Review Round 3 Accepted
2023-01-31 2023-02-02 2023-02-09 2023-02-16 2023-02-23
Conflict of Interest Funding Ethical Approval Plagiarism X-checker Note
Nil Nil Yes 18%

© 2023by Smriti Singh, Prathima, N.V. Gayathri Bhat, Govind Sharmaand Published by Maharshi Charaka Ayurveda Organization. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License https://creativecommons.org/licenses/by/4.0/ unported [CC BY 4.0].

Journal of Ayurveda and Integrated Medical Sciences 2023;8(3)42
Singh S et al: Pharmaceutical comparative study of Guduchyadi Malahara (ointment)

Introduction

Ayurveda has specified two types of Chikitsa – Antahparimarjana Chikitsa and Bahiparimarjan Chikitsa.[4] Bahiparimarjan Chikitsa means, the medicine for external use.[5] Malahara Kalpana comes under Bahiparimarjan.[6] The word Maraham and Malaham are basically originated from Unani system of medicine. In Ayurveda, Yogratnakar mentioned this, by the name of Malahara Kalpana, as it removes Mala from Vrana, Vidhradi, etc. In modern pharmaceutics it is called ointment.[7]

Guduchyadi Malahara is a modified formulation of Guduchyadi Kashaya. Guduchyadi Kashaya is described for treating Kaphaja Yoni Vyapat. It has Kandughna, Jantughna properties.[8]

Malahara can adhere to surface for sufficiently long periods before they can be washed off. This property helps prolong drug delivery at the application site. In general, Malahara have the cumulative property because of that it can stick on surface for long time.

Collection of Raw material: Raw materials required for Guduchyadi Malahara were procured from the SDM college of Ayurveda and Hospital, Hassan, Karnataka and local market. The entire herbal raw material samples were identified and certified as a genuine sample by Department of Dravyaguna, Sri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital, Hassan, Karnataka.

Pharmaceutical study: Guduchyadi Malahara was prepared in teaching pharmacy, Department of Rasa Shastra and Bhaishajya Kalpana, Sri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital, Hassan, Karnataka.

Preparation of Guduchyadi Malahara

Principle followed for the preparation of Guduchyadi Malahara was that of Siktha Taila as per the reference mentioned in Rasatarangini.[9,10]

Table 1: Materials used[11]

SN Drugs Botanical Name Part Used
1. Guduchi Tinospora cordifolia Stem
2. Amalaki Emblica officinalis Fruit
3. Haritaki Terminalia chebula Fruit
4. Vibhitaki Terminalia bellirica Fruit
5. Tila Taila - -
6. Madhuchisht - -

Equipments required: Heating device, Gas burner with LPG cylinder, Vessel, Double layered cotton cloth, weighing machine and beaker.

Procedure: The Guduchyadi Malahara was prepared by two different methods.

Method 1:

1. Fine powder of Guduchi, Amalaki, Vibhitaki and Haritaki were taken.

2. The base of Malahara was prepared by melting of bee wax. Physical impurities were seen in wax after melting it filtered through a cloth.

3. The fine powder of Guduchi, Amalaki, Vibhitaki, Haritaki were added in melted bee wax and Tila Taila in ratio of 1:5 and mixed well.

4. The prepared Malahara was preserved in clean, air tight plastic jar.

Method 2:

1. Initially whole Guduchi plant was taken and chopped into smaller pieces.

2. 2 kg of chopped Guduchi was taken and added 16 liters of water, and boiled until 4 liter Guduchyadi Kashaya was obtained.

3. One-liter Tila Taila taken in another vessel along with Guduchyadi Kashaya till foam appearance

4. Then 250 grams Kalka made up of Guduchi, Amalaki, Vibhitaki and Haritaki was added in

5. Heating is continuous till Sneha Siddhi Lakshanas

6. Guduchyadi Taila obtain and melted and purified bee wax added in it in the ratio of 6:1.

7. Cooling of Guduchyadi Malahara.

8. Packed in air tight jar.

Selection of Subjects

Diagnostic criteria (Signs and symptoms)

1. Thick Curdy white discharge

2. Wet vaginal smear positive to the candida albicans taken for the study.

Inclusion criteria

1. Subjects full fill the diagnostic criteria

2. Age 18-40 years

3. Married


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Singh S et al: Pharmaceutical comparative study of Guduchyadi Malahara (ointment)

4. Subjects willing to participate in the study and sign the written consent

Exclusion criteria

1. Post-menopausal

2. Pregnant women

3. Known case of HIV, HBSAg, VDRL

4. Under prolonged use of antibiotics

Method of application

Doses and time: Guduchyadi Malahara was applied once daily in sufficient quantity for 7 days.

Purvakarma: Subjects were asked to empty the bladder and made to lie in lithotomy position. Under aseptic precautions Cusco’s bivalve self-retaining speculum was inserted and cervix exposed. If any white discharge is present, it cleaned with sterile gauze piece. 300 ml Sukoshna Jala was taken and Yoni Prakshalana was carried out with 50 ml syringe. Local area was dried with Gauze.

Pradhankarma: Guduchyadi Malahara of sufficient quantity was taken with Pichu and directly applied over the cervix and vaginal walls.

Pashchat Karma: Subject were asked to remove Pichu by herself after 3 hours or Amutrakala.

All subjects were randomly grouped in to 2 groups –

Group A - Subjects in whom Malahara prepared as per method 1 was applied.

Group B - Subjects in whom Malahara prepared as per method 2 was applied.

Observations and Results

Guduchyadi Malahara was applied with Pichu in vagina of six patients (3 patient for each method of preparation) as the treatment of vulvo vaginal candidiasis after Yoni Prakshalana with Sukhosna Jala and observations were noted.

Table 2: Guduchyadi Malahara prepared as per method 1 was applied in Group-A.

SN Curdy White Discharge Vaginal Itching Redness In Vulva
BT AT BT AT BT AT
1 Present Absent Present Present Present Present
2 Present Absent Absent Present Absent Present
3 Present Absent Absent Present Absent Present

Table 3: Guduchyadi Malahara prepared as per method 2 was applied in Group-B.

SN Curdy White Discharge Vaginal Itching Redness In Vulva
BT AT BT AT BT AT
1. Present Absent Present Absent Present Absent
2. Present Absent Absent Absent Absent Absent
3. Present Absent Present Absent Absent Absent

The vaginal smear repeated after 7 days of treatment, it become negative for candida albicans for all subjects.

Discussion

Vagina is a fibromusculo membaranous sheath and very sensitive area of female reproductive system as well as body.[12]

It was observed that Guduchyadi Malahara prepared by both methods is having ability to reduce the symptoms of Kaphaja Yoni Vyapat as curdy white discharge. But Malahara prepared by method 1 was not beneficial to cure vulval redness and vaginal itching. Out of three patient two patients got these symptoms after the treatment, however one patient already having these symptoms and it persists after treatment.

Malahara prepared by method 2 is having capability to treat vulval redness as well as itching. After treatment no patient reported these symptoms.

Guduchyadi Malahara prepared by method 1 having Churna, there are chances of persistence of rough particles that may cause irritation to vaginal mucosa and vaginal wall got inflamed. Guduchyadi Malahara prepared by method 2 was having smooth consistency, so there is no irritation to the vaginal mucosa.

Conclusion

Hence Malahara prepared by method 2 is safer for application in vagina. As vagina is made up of very soft tissues, one should be very careful during any application in vagina.

Modification of Guduchyadi Kashaya into Guduchyadi Malahara with respect to shelf life, Guduchyadi Malahara has a longer shelf life than Kashaya, and soft consistency making it more comfortable.



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Reference

1. Reetesh Ramnani, Mukesh Chaudhari, Amit kumar Sharma, K. Shankar Rao. A Randomized Clinical Trial of Rasapushpadi Malahara on Vicharchika w.s.r.to Eczema. International Journal of Ayurveda and Pharma Research. 2019;7(5):49-55.

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3. Yogaratnakara. Yonivyapat Chikitsa Verse 6. In: Sastri B B(edi.). Yogaratnakara with Vidyotini Hindi Commentary. Reprint 2018 edition. Varanasi: Chaukhambha Prakashan; 2018 p.411

4. Agnivesha, Charaka, Dridabala, Chakrapanidatta. Sutrasthana Chapter 3 Aaragvadheeyam Adhyaayam Verse 1 Chakrapanidatta. In: Acharya Y T(edi.). Charakasamhita with Ayurveda Deepika Commentary. Reprint 2013 edition. Varanasi: Chaukhambha Orientalia; 2013: p.27.

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7. K.C. Reddy. Bhaishajya Kalpana Vidnyanam. Chaukhambha Sanskrit Bhawan, Varanasi, 2nd Edition, 2011; 414: 415

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9. Pranacharya Shri Sadananda Sharma, “Rasatarangini”, Motilal Banarasidas Publication, Delhi, Edition, 2014; 114.

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