E-ISSN:2456-3110

Research Article

Acne Vulgaris

Journal of Ayurveda and Integrated Medical Sciences

2024 Volume 9 Number 2 February
Publisherwww.maharshicharaka.in

A clinical study of Sidharthakadi Lepa in management of Yuvanpidika (Acne Vulgaris)

Kumar M1*, Kumar Mishra P2, Sharma B3
DOI:10.21760/jaims.9.2.3

1* Maneesh Kumar, Post Graduate Scholar, Department of Swasthavritta Yoga, Pgia Dr Sarvepalli Radhakrishnan Rajasthan Ayurved University, Jodhpur, Rajasthan, India.

2 Pramod Kumar Mishra, Post Graduate Scholar, Department of Kayachikitsha, PGIA Dr Sarvepalli Radhakrishnan Rajasthan Ayurved University, Jodhpur, Rajasthan, India.

3 Brahmanand Sharma, Post Graduate Scholar, Department of Swasthavritta Yoga, PGIA Dr Sarvepalli Radhakrishnan Rajasthan Ayurved University, Jodhpur, Rajasthan, India.

Introduction: Acne is a distressing condition that affects the majority of adolescents and harms beauty of the face so person may suffer with inferiority complex, anxiety, isolation etc. Due to wide spectrum of disease, much prevalence in the society and lack of effective medicine, this is the main cause of the global shift toward Ayurveda and Herbal skin care. The present study was conducted to evaluate the effect of Sidharthakadi Lepa in management of Yuvanpidika. Methodology: Single arm open randomized clinical study was conducted on 40 clinically diagnosed patients with Acne Vulgaris for Sidharthakadi Lepa in the Postgraduate Institute of Ayurveda, DSRRAU, Jodhpur. Study evaluates their role in management of Pidika (Prescence of Acne), Kandu (Itching), Vedana (Pain), Daha (Burning sensation) and Srava (Discharge) Results: Result of the study depicts that Lepa has significantly helps in reducing the Acne vulgaris. Conclusion: Out of 40 patients selected for the study, a greater number of young adults & 11 patients were male and 29 were female. It showed the high rate of occurrence and consciousness of this condition in females. Sidharthakadi Lepa is more effective in Vata and Kapha Prakrithi individuals.

Keywords: Acne, Cosmetology, Yuvanpidika, Lepa, Sidharthakadi Lepa

Corresponding Author How to Cite this Article To Browse
Maneesh Kumar, Post Graduate Scholar, Department of Swasthavritta Yoga, Pgia Dr Sarvepalli Radhakrishnan Rajasthan Ayurved University, Jodhpur, Rajasthan, India.
Email: 		Kumar M, Kumar Mishra P, Sharma B, A clinical study of Sidharthakadi Lepa in management of Yuvanpidika (Acne Vulgaris). J Ayu Int Med Sci. 2024;9(2):10-14.
Available From
https://jaims.in/jaims/article/view/3116

Manuscript Received Review Round 1 Review Round 2 Review Round 3 Accepted
2023-12-14 2023-12-24 2024-01-04 2024-01-14 2024-01-23
Conflict of Interest Funding Ethical Approval Plagiarism X-checker Note
None declared Nil Yes 20.22

© 2024by Kumar M, Kumar Mishra P, Sharma Band Published by Maharshi Charaka Ayurveda Organization. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License https://creativecommons.org/licenses/by/4.0/ unported [CC BY 4.0].

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Maneesh Kumar et al. A clinical study of Sidharthakadi Lepa in Yuvanpidika

Introduction

The most prevalent skin condition caused by today's lifestyle, poor food, and pollution is Acne Vulgaris which affects the skin directly and leads to many other skin conditions. According to Global burden of disease study Acne vulgaris affected 85% of young adults with age group ranging from 12-25 years.[1] Teenagers go through a lot of physical and psychological changes, and acne is the eighth most frequent health issue worldwide.[2] According to data, between the ages of 12 and 24 years, almost 85% of adults have at least mild acne.[3]

The face is the index of the mind and the mirror of the body. Yuvanpidika harms beauty of the face so person may suffer with inferiority complex, anxiety, isolation etc. Thus, Yuvanpidika is a painful condition for body as well as for mind too. The latest medical research recommends antibiotics, hormone therapy, and some surgical or para-surgical procedures including laser therapy. Herbal formulations can be a superior solution to provide efficient & economical management for acne because these measures have some restrictions in addition to negative side effects. Due to wide spectrum of disease, much prevalence in the society and lack of effective medicine, this is the main cause of the global shift toward Ayurveda and Herbal skin care. The disease is being chosen for the study.

Yuvanpidika (Mukhadushika) is one of such disease in Ayurveda. Acharya Sushruta has described Yuvanpidika as eruption like Shalmali throne on the face of human being is called Yuvanpidika.[4] The disease has described under Kshudraroga chapter by many classical texts. Yuvanpidika is caused due to Dushita Kapha and Vata along with Dushita Rakta dhatu. Romakupa obstructed due to vitiated Dosha and Dushya causing Yuvanpidika. They mostly occur in the youths or the Yuva and in form are like small pustules or boils or Pidika hence they are called ‘Yuvanpidika.’ And for the same reason it is also called ‘Tarunyapidika.’ This disease affects the face and vitiates the facial appearance this is called ‘Mukhadushika.’ Acne is chronic inflammatory condition of skin with significant cutaneous and psychological disease. It is present in both male and female. Male are more prone to it since onset of puberty.

Ayurveda an ancient science has

vast description of the topical applications in the name of Lepakalapna described both as the Chikitsa of various skin disease and for beauty. The medicine that are in the form of a paste and used for the external application are called Lepas. Mukhalepa is a simple and effective skin care treatment in Ayurveda[5] In the context of Yuvanpidika, Sharngdhara Samhita described Sidharthakadi Lepa.[6]

Thus this study is conducted to assess the effectiveness of Sidharthakadi Lepa in management of Yuvanpidika (Acne vulgaris) and provide a cost effective, side effect free, easy to use Lepa in Yuvanpidika.

Materials and Methods

Study Type: Single group, open randomized clinical study.

Ethical clearance: the present study was approved by IEC vide letter number – DSRRAU/UPGIAS&R IEC/20-21/414 dated on 12/06/22.

CTRI Registration: CTRI No. – CTRI/2022/11/047134 registered on 11/09/2022

Selection of cases

40 clinically diagnosed patients of Yuvanpidika (Acne vulgaris) were selected from the O.P.D/ I.P.D unit of DSRRAU Hospital Jodhpur. A regular record of the assessment of all patients was maintained according to form prepared for the purpose. Following inclusion and exclusion criteria were used for registration of the patients for present clinical trial.

Inclusion Criteria

Patients belonging to both genders will be included; Patients between the age group of 13 to 35 years will be included; Patients with sign and symptoms of Yuvanpidika as per Ayurveda & modern; Chronicity less than 5 years.

Exclusion Criteria

Patients of age below 13 years & above 35 years of either sex with hormonal imbalance; Acne due to malignant cases; Acne associated with other skin disease or febrile conditions; Patients on Anti-tubercular disease.




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Maneesh Kumar et al. A clinical study of Sidharthakadi Lepa in Yuvanpidika

Study Design

Study typeInterventional (clinical study)
PurposeTreatment
AllocationRandomized
MaskingOpen label
End pointEfficacy & Safety

Trial Drugs

Taking the symptoms and the Samprapti of Yuvanpidika into consideration, a proposed drug formulation namely " Sidharthakadi Lepa " was selected. The drug selected for the study contained main ingredients as mentioned below.

Table 1: Properties of ingredient of Sidharthakadi Lepa.

Sanskrit nameFamilyRasaGunaVeeryaVipakaDoshagnata
SidharthakaCruciferaeKatu, TiktaTikshnaUshnaKatuVata Kapha Shamaka Pitta Vardhaka
VachaAraceaeKatu, TiktaUshna TikshnaUshnaKatuKapha Vatahara
LodhraSymplocaceaeKashayaUshna RukshaSheetaKatuKapha Pitthara
SaindhavaSodii chloridumLavanaKinchit Guru, Snigdha and TikshnaUshnaKatuTridoshaghna

Method of preparation of Lepa

The above mentioned drugs are powdered individually in a Khalvayantra to get fine powder. Equal quantities of powders of individual drugs are taken in a vessel and mixed with normal water to make them into a Lepa or paste form. This Lepa is applied over the face. Method of preparation of Lepa The above mentioned drugs are powdered individually in a Khalvayantra to get fine powder. Equal quantities of powders of individual drugs are taken in a vessel and mixed with normal water to make them into a Lepa or paste form. This Lepa is applied over the face. The above mentioned drugs are powdered individually in a Khalvayantra to get fine powder. Equal quantities of powders of individual drugs are taken in a vessel and mixed with normal water to make them into a Lepa or paste form. This Lepa is applied over the face. The above mentioned drugs are powdered individually in a Khalvayantra to get fine powder. Equal quantities of powders of individual drugs are taken in a

vessel and mixed with normal water to make them into a Lepa or paste form. This Lepa is applied over the face.

Administration of Drugs

In Single Group, 40 Clinically diagnosed and registered patients of Yuvanpidika (Acne Vulgaris) was given external application of Sidharthakadi Lepa twice in a day with water on the acne (as per need) for 3 months and follow up by 15 days.

Criteria Assessment

Subjective Parameters

Patients having classical features of Yuvanpidika like-(Table 2)

Pidika (Prescence of Acne)
0- No Acne
1- Few areas of face
2- Both side of cheeks & forehead
3- Both side of cheeks, forehead & trunk
Kandu (Itching)
0- Absent
1- Occasionally
2- Continues itching without disturbing sleep
3- Continues itching with disturbing sleep
Vedana (Pain)
0- No Pain
1- Pain after Itching
2- Pain during Inflammation
3- Continues pain
Daha (Burning sensation)
0- No burning
1- Occasionally
2- Continuous burning without disturbing sleep
3- Continuous burning with disturbing sleep
Srava (Discharge)
0- Absent
1- Occasionally & Small quantity
2- Perfuse discharge in all age
3- Continues discharge in all acne

Result

In the present study 40 patients were studied. After completion of the clinical study, Observations in Yuvanpidika were recorded in the form of charts and tables. Observations related to Age, sex, diet, Habit, Prakriti were recorded as follows. It was observed that 55% belonged in age group of 23–27-year patients and 27.5% patients belonged


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to 18–22-year age group and 17.5% in 28-32 year of age. Majority of female patients were registered for study i.e., 29(72.50%) and male patients were 11(27.50%). In the present study it was observed that 22 (55%) were of Vata Kaphaja Prakruti, 12 (30%) were of Pitta Kaphaja Prakruti, 6 (15%) were of Vata Pitta Prakruti. Out Of 40 patients 30 (75 %) were of vegetarian Diet group and 10 patients (25%) were of vegetarian diet group.

All the Results are calculated by using Software: In Stat GraphPad 3(version 3.10)

For Nonparametric Data Wilcoxon matched-pairs signed ranks test is used.

Wilcoxon matched paired single ranked test in individual group before and after scores.

Table 3: Showing effect of therapy in Subjective Parameters.

VariableMeanMean Diff.% ReliefSD±SE±PS
BTAT
Pidika2.2500.90001.35060.000.48300.07638<0.0001ES
Kandu1.7500.70001.05060.000.22070.03490<0.0001ES
Vedana0.52500.27500.250047.610.43850.069340.0020VS
Daha0.17500.075000.100057.140.30380.048040.1250NS
Srava0.87500.47500.400045.710.49610.07845<0.0001ES

jaims_3116_01.JPG

Discussion

Discussion regarding probable mode of action of Sidharthakadi Lepa

Sidharthakadi Lepa containing Sidharthaka, Vacha, Lodhra and Saindhava Lavana.

Sidharthaka, Vacha, Lodhra and Saindhava Lavana - Being (Vacha, Sarshapa) Katu and Tikshna (Lodhra - Kashaya Rasa Pradhana)

in Rasa and Ushna Virya (Saindhava Lavana) helps improve the condition of Yuvanpidika, since Katu and Rukhsana are Ruksha in nature and help in scraping (Lekhana) out the Medas from the Pidika. Even Kashaya rasa acts as the Vruna Ropaka. Additionally, Ushna Virya helps in sebum ventilation and vessels dilation. These drugs being Kapha Vatagna property and Vedana Sthapana, helps to take out the excess accumulated Kapha and Vata, and even helps to reduce the localized pain over the lesions. Being Twaka Prasadaka helps to normalize the deranged skin. Vacha is considered as the best Shotahara. Swelling on the acne lesion is reduced by the application of Vacha Churna.

Lodhra by its Kashaya Rasa even helps to contract the vessels and acne by which it eliminates the sebum and pus. Vacha and Sarshapa mainly consist of essential oil, zinc, magnesium, Eugenol and palmitic acid. Lodhra has qualities that help to balance Kapha Pitta, including anti-dermatitis, wound healing, astringent, and drying.[7] Lodhra is a cold-potent drug that improves Pittaja symptoms including burning, suppuration, and redness. Lodhra's cool potency helps in the decrease of aggravated Rakta and Pitta Dosh.[8] Its capacity to heal wounds expedites recovery and healing. Acharya Sushruta noted that Lodhra had the ability to improve one's complexion. Vacha has characteristics that reduce Kapha and Vata, scrape, are subtle (fineness), and induce sweating.[9] These characteristics allow it to enter deep micropores, where it causes the buildup of sebum to be scraped out and unblocks the pores. As a result, it gradually contributes to a decrease in acne cases. According to recent pharmacological studies, Vacha also has hyperaemic, antibacterial, analgesic, antisecretory, and antiulcerogenic effects. These properties help to relieve pain, swelling, and redness.[10]

Properties that promote drying and healing of the papules include absorbency, dryness, and healing. Astringent medications' detoxification abilities cause the blood's vitiated components to be purified, curing skin conditions in the process. Moreover, it improves the colour of the skin. The medications are analgesic, antimicrobial, anti-inflammatory, and have wound-healing qualities.[11]

Conclusion

The conclusion of the present study is that Age


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(Vaya) is the Pradhana Hetu, this may be due to increase in hormonal activity at that age group and more stress level. The other Nidanas such as Aharaja, Viharaja are Nimittaja Hetu. Pitta Dosha Pradhana Prakruti persons are more susceptible to Yuvanpidika i.e., Pitta associated with Kapha or Pitta associated with Vata. Excessive intake of Apathyakara Aharavihara, In Yuvaavastha is important Hetus of Yuvanpidika. Application of Sidharthakadi Lepa is very beneficial for Yuvanpidika. Hence its role in disease was proved. Sidharthakadi Lepa reduces Kandu, Vedana, Daha, and Srava of Yuvanpidika. Sidharthakadi Lepa did not show any adverse effect during present study. Regular Practice of Sidharthakadi Lepa is helpful to prevent Yuvanpidika. Overall result of the thesis is satisfactory one. Thus, it can be concluded that Sidharthakadi Lepa may be used as main therapeutic agent in established cases of Acne vulgaris or as an adjuvant therapy in chronic and complicated cases. Acne Vulgaris for the promotion and maintenance of positive health.

The study is bound to have certain limitations. The data thus gathered through primary information are supposed to be facts. The sample size was too small to generalize the results for all populations.

References

1. Department of Dermatology, University of Colorado School of Medicine, Aurora, CO, USA

2. Hay, RJ; Johns, NE; Williams, HC; Bollinger, IW: Della Valle, RP; Margolis, DJ, Marks, R Naldi, L. Weinstock, MA; Wulf, SK, Michaud, C; Murray, C; Naghavi, M (October 2013). "The Global Burden of Skin Disease in 2010: An Analysis of the Prevalence and Impact of Skin Conditions". The Journal of Investigative Dermatology, 134 (6): 1527-34.

3. Bhate K, Williams HC. Epidemiology of acne vulgaris. The British journal of dermatology 2013, Pg no.474-85

4. Shastri Ambikadatta Kaviraj, Ayurveda Tattva Sandipika Hindi commentary of Sushruta Samhita, Chaukhambha Sanskrit Sansthan (2013), Vol.1 nidan sthan 13/38, Pageno.392

5. Bhate K, Williams HC. Epidemiology of acne vulgaris. The British journal of dermatology 2013, Pg no.474-85

6. https://ijapr.in/index.php/ijapr/article/view/633#:~:text=The%20herbal%20paste%20which%20is, using%20variety%20of%20herbal%20pastes.

7. Srivastava Shailaja smt., Jiwanprada Hindi commentary of Sharngdhar Samhita, Chaukhambha Orientalia (2003) Uttar khanda 11/11, page no.428

8. https://www.athayurdhamah.com/about-ayurveda/lodhra

9. Kathait R., Tripathi SK, Sharma SK, Kala JS Shukla S. A clinical study to evaluate efficacy of Lodhradi Lepa and Mukhdooshikaharvati along with Virechana in the valuate management of Mukhadooshika w.s.r. acne vulgaris. Int J Ayur Pharma Chem2018; 9:251. Back to cited text no.28.

10. Sharma PV. Dravya Guna Vijnana. Vol 1. Reprint ed., Varanasi: Chaukhambha BhartiAcademy, 2006. p. 616.

11. Sharma PV. Dravya Guna Vijnana. Vol 1. Reprint ed., Varanasi: Chaukhambha Bharti Academy, 2006. p. 28.


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