E-ISSN:2456-3110

Review Article

Ksharapippali in Vatashteela

Journal of Ayurveda and Integrated Medical Sciences

2024 Volume 09 Number 06 JUNE
Publisherwww.maharshicharaka.in

A conceptual study on efficacy of Ksharapippali in Vatashteela

Akruthi SG1*, Srinivas M2
DOI:10.21760/jaims.9.6.23

1* Akruthi S Gowda, Post Graduate Scholar, Department of Shalyatantra, Govt Ayurveda Medical College, Bengaluru, Karnataka, India.

2 Srinivas Masalekar, Professor and Head, Department of Shalyatantra, Govt Ayurveda Medical College, Bengaluru, Karnataka, India.

Benign Prostatic Hyperplasia (BPH) is essentially a disease of old age in males, with the prevalence of around 50% by the age of 60 years. It is a condition with increase in size of the prostate, which exerts pressure on the urethra leading to obstruction to flow of urine. Acharya Sushrutha has explained in detail about obstructive and irritative symptoms of the Urinary bladder under the heading of Mutraghata in Uttaratantra.[1] Vatashteela is one among the 12 types of Mutraghata, where aggravated Vata gets localised in between Basti and Shakritmarga, producing a dense fixed stone like glandular swelling leading to obstruction of Vit, Mutra and Anila with Adhmana and Teevra Ruja in Basti Pradesha.[2] Acharya Vangasena has indicated Ksharapippali[3] in Vatashteela in Chikitsasaara Sangraha which has got many drugs with mutrala properties. Hence this study has been taken up to assess the efficacy of Ksharapippali in Vatashteela with emphasis on its probable mode of action.

Keywords: Vatashteela, Mutraghata, Ksharapippali, Benign Prostatic Hyperplasia, BPH

Corresponding Author How to Cite this Article To Browse
Akruthi S Gowda, Post Graduate Scholar, Department of Shalyatantra, Govt Ayurveda Medical College, Bengaluru, Karnataka, India.
Email:
Akruthi SG, Srinivas M, A conceptual study on efficacy of Ksharapippali in Vatashteela. J Ayu Int Med Sci. 2024;09(06):155-158.
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https://jaims.in/jaims/article/view/3257

Manuscript Received Review Round 1 Review Round 2 Review Round 3 Accepted
2024-04-12 2024-04-23 2024-05-03 2024-09-13 2024-05-23
Conflict of Interest Funding Ethical Approval Plagiarism X-checker Note
Authors state no conflict of interest. Non Funded. The conducted research is not related to either human or animals use. 13.14 All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

© 2024by Akruthi SG, Srinivas Mand Published by Maharshi Charaka Ayurveda Organization. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License https://creativecommons.org/licenses/by/4.0/ unported [CC BY 4.0].

Introduction

Sushruta describes Vatashteela among the 12 types of Mutraghata. In this condition Apana Vayu, gets localised in between Basti (urinary bladder) and Shakritmarga (rectum), produces a dense fixed stone like glandular swelling, leading to obstruction of Vit, Mutra and Anila with Adhmana and produces Teevra Ruja in Basti Pradesha. Vatashteela reflects the symptoms of urine retention, incomplete voiding, increased frequency, urgency, hesitancy, difficulty in micturition, weak stream, dribbling and straining during micturition. These  features have striking similarities with Benign Prostatic Hyperplasia (BPH).

It is one of the most prevalent obstructive uropathy of advanced age group in males, rises markedly after the age of 40 years. Peak incidence of 8% in the 4th decade of life, 50% in the 6th decade and 80% in the 9th decade of life is observed. It is the most common cause of Bladder Outlet Obstruction.[4]

The conservative treatment includes either α 1n adrenoreceptor blockers or 5 α reductase inhibitors or both in combination which are known to cause dizziness, decreased libido, retrograde ejaculation, impotence, postural hypotension, gynaecomastia, skin rashes and few vascular side effects.[5]

Withdrawal of these drugs result in regrowth of prostate. Surgical procedures includes Transurethral Resection of Prostate (TURP), Freyer’s suprapubic transvescical Prostatectomy, Millin’s Retrograde prostatectomy, Microwave treatment, Holmium laser treatment, Intraurethral stents, etc. The surgical interventions are difficult because of old age and with the association of conditions like CVD, Pulmonary conditions, HTN and DM. However, surgery is invasive, expensive and has post-op complications like haemorrhage, infection, incontinence, perforation of bladder, stricture urethra, retrograde ejaculation, impotence and recurrence.

Ayurveda advocates various treatment modalities like Kashaya, Kalka, Ghrita, Bhakshya, Lehya, Paya, Kshara, Madya, Asava and Swedana and Uttarabasti in Mutraghata. One such formulation described by Acharya Vangasena in Chikitsasaara Sangraha is Ksharapippali. It includes ingredients like Bala and Manakanda which have Mutrala (diuretic) property.

The other ingredients viz., Shirisha, Chitraka, Varuna and Punarnava contain β-sitasterol, which has been proved potential in reducing BPH by improving urinary symptoms and enhancing flow measures.[6]

Disease Review

Benign prostate hypertrophy is a disease process with a well-defined age incidence. It is essentially a disease of old age, after 50 years. Only under rarest circumstances it may occur in early life. Enlargement of prostate gland is due to formation of one or more nodules. These nodules may fuse together to form one mass. The enlargement may involve any part of the gland except the posterior lobe and the anterior lobe. The two lateral lobes and the median lobes are frequently involved.

Clinical features:

Benign enlargement of prostate seldom causes symptoms before the age of 50 years. There is no direct relation between the degree or enlargement and the severity of symptoms. The symptoms include hesitancy, frequency, urgency, dysuria, haematuria, pain, weak steam, terminal dribbling, enuresis, retention of urine.[7]

The symptoms observed in benign prostatic hyperplasia (BPH) closely resemble those described as Vatashteela under Mutraghata.

Nidana:

While there are no distinct causes outlined for Vatashteela or Mutraghata, the factors contributing to Mutrakricchra can be considered relevant for Vatashteela as well. Vatakundalika and all types of Mutraghata are produced by one or more Tridoshas, by causes such as suppression of natural urges etc. as explained in Madhava Nidana-31st chapter.

Among the Nidanas mentioned for all the 12 types of Mutraghata, Vegadharana is considered to be the root factor in manifestation which is discussed in 31st chapter of Madhava Nidana. Along with this, Vatadushti is also a contributory factor for causation of the disease.

On commentating Sushrutha Uttaratantra, Acharya Dalhana quotes that Vata is the main factor in the pathogenesis of Mutraghata. When Vata gets Avrita by Mutra it causes Mutra Apravritti and Adhmana in Basti.


Types:
Acharya Sushrutha has explained Mutraghata in Uttaratantra in the 58th chapter, wherein he mentions 12 types viz,

1. Vatakunadalika
2. Vatashteela
3. Vatavasti
4. Mutraateeta
5. Mutrajathara
6. Mutrasanga
7. Mutrakshaya
8. Mutragranthi
9. Mutrashukra
10. Ushnavata
11. Mutrouksada pittaja
12. Mutrokusada kaphaja

Acharya Vagbhata has also described 12 types of Mutraghata[8], last one being Vidvighata. Acharya Caraka[9] and Madhavakara has explained 13 types, adding Vastikundala to the above list.

Samprapti:
Mityaahara and Vihara/Abhigata/Vega Nigrahana

Apana Vata Dushti

Sthanasamshraya in between Guda and Basti

Ashteelavat Ghana Granthi is formed

Vatashteela

Chikitsa:

The treatment prescribed for Mutraghata can also be applied to Vatashteela since there is no distinct treatment specified for Vatashteela, which includes modalities like Nidana Parivarjana, Shodhana, Shamana, Shastra Pranidhana, Rasayana and Pathya-Apathya.

Yoga Ratnakara has advised Snehana and Swedana therapies first followed by Sneha Virechana and Uttarabasti. Various Kashaya, Kalka, Ghrita, Bhakshya, Lehya, Paya, Kshara, Madya, Asava and Swedana and Uttarabasti is been advised in Mutraghata by Acharya Sushrutha.

Acharya Vangasena in his Cikitsasaara Sangraha, has advised Ksharapippali in the management of Vatashteela, Yakrit-Pleeha Roga and in Tridoshaja Gulma in Udararogadhikara Adhyaya.

Drug Review

Ksharapippalli, mentioned in the criteria of Vatashteela by Vangasena contains the following;

Pippali (Piper longum)
Ajamoda (Apium graveolens)
Samudra Lavana
Vamsalochana (Bambusa arudinaceae)
Akshota (Juglans regia)
Shirisha (Albizzia lebbeck)
Lodhra (Symplocos racemosa)
Punarnava (Boerrhavia diffusa)
Manakanda (Alocacia indica)
Snuhi (Euphoria nerrifolia)
Ajagandha (Cleome gynandra)
Aragwadha (Cassia fistula)
Varuna (Crataeva nurvula)
Shigrumula (Moringa pterygosperma)
Bala (Sida rhombifolia)
Chitraka (Plumbago zeylanica)
Yavakshara (Potassi carbonas)
Go Mutra
Jala

Method of Preparation:
Pippali, Ajamoda, Samudra Lavana, Vamsa, Akshota, Apamarga, Sirisha, Lodhra, Punarnava, Manakanda, Snuhi, Ajagandha, Aragwadha, Varuna, Shigrumoola, Bala, Chitraka each 200g and Yavakshara 1kg are cooked in 2.56 litres water, added with Cow urine equal to the water. It should be cooked accordingly, slowly.

Administration:
It should be administered with ghee as Anupana.

Indications:
Vatashteela, Enlargement of Liver and spleen and Gulma caused by Tridosha.

Discussion

Probable mode of action of Ksharapippali:

Pippali: having Katu Rasa, Madhura Vipaka has Vatahara and Kaphaghna properties.
Ajamoda: is Vatanulomaka, Vatashamaka and Mutrala.[10]
Samudra Lavana -has alkaline properties, Avidahi and is Vatanashaka.
Vamsalochana: bearing Kashaya Rasa has Bastishodhaka[11] property.


Akshota: has essential nutrients, minerals and vitamins B, A and C.
Apamarga having Tikta, Katu Rasa with Ushna Virya has Mutrajanana[12] and Kaphaghna properties.
Sirisha: is Ushna, with Tikta Kashaya Rasa is Tridoshaghna. And has saponin and tannin 7-11%.
Lodhra: is Shothaghna and Balya.
Punarnava: has Mutravirechana property.
Manakanda: has Mutrajanana property.
Snuhi latex: is Teekshna Virechaka.
Ajagandha: is Anulomaka and Shoolahara. And contains β-sitosterol.
Aragwadha: is Kaphaghna and Mutrajanaka.
Varuna: has Saponin and tannins. Has Vatanashaka, Mutrajanana, Ashmarighna and Shothaghna properties. It’s bark is indicated in Mutravikaras.[13]
Shigrumoola: has Vatanulomaka, Vatahara, Kaphahara, Mutrajanana and Shothahara properties.
Bala: is Sheeta Virya and has Balya, Rasayana and Sangrahi properties.
Chitraka: is Agnideepaka, Rasayana, Vata-Kaphahara.
Yavakshara: is Agnideepaka, Mruduvirechaka and mild diuretic.
Bala, Manakanda, Punarnava, Varuna and Yavakshara are diuretics.Sirisha, Citraka, Varuna, Punarnava, Ajagandha contains β-sitosterol, which has been proved potential in reducing BPH by improving urologic symptoms and flow measures.

Conclusion

Ksharapippali, a formulation explained by Vangasena indicated in Vatashteela contains the ingredients with diuretic properties and the chemical constituents like β-sitosterol. Various studies show β-sitosterol has been proved potential in reducing BPH by improving urologic symptoms and flow measures. Hence Ksharapippali can be considered a potent formulation in treating Vatashteela (BPH).

References

1. Sushruta, Sushruta samhita, with the Nibandha Sangraha commentary of Sri Dalhana Acharya, Edited by Vaidya Yadavaji Trikumji Acharya, Chaukhambha Surabharati Prakashama, Varanasi reprint 2003, Uttara Tantra Chapter 58/1-2 pp824

2. Madhava Nidanam of Madhavakara with English Translation by Prof. K.R.Srikantha Murthy, Chaukambha Orientalia, Varanasi, Second Edition. Chapter 31/4 Pg No.110

3. Cikitsasara Sangraha of Vangasena, by Dr. Nirmal Saxena, Chaukhambha Sanskrit Series Office, Varanasi, 2nd Edition 2014, Vol – 1 Chapter 42/201-204, Pg No.614

4. A Concise text book of surgery-by Somen.Das, Published by Dr. S. Das, 10th Edition 2018, Chapter 50 Pg.1271-1283
5. Essentials of Medical Pharmacology by KD Tripathi, 7th edition Jaypee Publications, Pg No. 302

6. Beta‐sitosterols for Benign Prostatic Hyperplasia, Timothy J Wilt, Areef Ishani, [...], and. Cochrane Urology Group, Cochrane Database Syst Rev. 1999 Jul; 1999(3): CD001043. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407049/#__ffn_sectitle

7. A Concise text book of surgery-by Somen. Das, Published by Dr. S. Das, 10th Edition 2018, Chapter 50 Pg.1271-1283

8. Ashtanga Hridaya of Vagbhata, translated by Prof. K. R.Srikantha Murthy, Chaukhambha Krishnadas Academy Varanasi, 10th Edition 2014, Vol-1 Sutra Sthana, Chapter 30Charaka 10.

9. Samhita revised by Charak and dridabala edited and translation by PV sharma 7 edition vol.2 Varanasi: Chaukhambha Orientalia series ;2005 Chikitsa 26

11. Bhavaprakasha Nighantu, commentary by professor Krishnachandra Chunekar, edited by Dr. Gangasahay Pandey, published by Chaukhambha Bharati Academy, Pg. 26

12. Bhavaprakasha Nighantu, commentary by professor Krishnachandra Chunekar, edited by Dr. Gangasahay Pandey, published by Chaukhambha Bharati Academy, Pg. 361

13. Bhavaprakasha Nighantu, commentary by professor Krishnachandra Chunekar, edited by Dr. Gangasahay Pandey, published by Chaukhambha Bharati Academy, Pg. 399

14. Bhavaprakasha Nighantu, commentary by professor Krishnachandra Chunekar, edited by Dr. Gangasahay Pandey, published by Chaukhambha Bharati Academy, Pg. 531