E-ISSN:2456-3110

Research Article

Haridradi Yog

Journal of Ayurveda and Integrated Medical Sciences

2024 Volume 9 Number 11 NOVEMBER
Publisherwww.maharshicharaka.in

An Etiopathological Study and Therapeutic Intervention of Haridradi Yog (A Hypothetical Ayurvedic Formulation) on Covid - 19 Recovered Patients of Madhumeha w.s.r. to Type 2 Diabetes Mellitus

Kumari S1*, Sharma MM2
DOI:10.21760/jaims.9.11.12

1* Sunita Kumari, Post Graduate Scholar, PG Dept of Rog Nidan Evum Vikriti Vigyan, Madan Mohan Malviya Govt Ayurved College, Udaipur, Rajasthan, India.

2 Man Mohan Sharma, Professor and HOD, PG Dept of Rog Nidan Evum Vikriti Vigyan, Madan Mohan Malviya Govt Ayurved College, Udaipur, Rajasthan, India.

Purpose: The Madhumeha (DM) are vulnerable to many bacterial & viral infections, They are more prone to be infected with the COVID-19. And after contracting with the COVID-19 they have experienced more aggravation in their symptoms like in pneumonitis etc. Many research studies have revealed that COVID-19 had the very bad effect on Madhumeha patients. It is typically observed in both the first wave and the second wave of COVID-19. The diabetic patient who contracted COVID-19 had the highest mortality rate. Among the 66 COVID-19 patients hospitalised, there were 44 non-diabetic cases and 22 cases of diabetes. Madhumeha is compared and correlated with Diabetes mellitus.

Method: In this clinical study, 30 clinically diagnosed patients were administered Indigenous Formulation 5gm twice a day in empty stomach for 60 day with Luke warm water.

Result: The result was statistically Very significant in Prabhut Mutrata, Durbulaya, FBS, PPBS. While statistically significant in Pipasa Adhikya, Kshudha Adhikya, Kar-Pad-Tala Daha & Supti, Urine Specific Gravity. Conclusion: From the observation & result it can be concluded that Indigenous Formulation can be used effectively in the management of Diabetes Mellitus Type -2 (COVID -19 recovered patients).

Keywords: Diabetes Mellitus Type -2, COVID -19, Indigenous Formulation

Corresponding Author How to Cite this Article To Browse
Sunita Kumari, Post Graduate Scholar, PG Dept of Rog Nidan Evum Vikriti Vigyan, Madan Mohan Malviya Govt Ayurved College, Udaipur, Rajasthan, India.
Email: 		Kumari S, Sharma MM, An Etiopathological Study and Therapeutic Intervention of Haridradi Yog (A Hypothetical Ayurvedic Formulation) on Covid - 19 Recovered Patients of Madhumeha w.s.r. to Type 2 Diabetes Mellitus. J Ayu Int Med Sci. 2024;9(11):81-86.
Available From
https://jaims.in/jaims/article/view/3455

Manuscript Received Review Round 1 Review Round 2 Review Round 3 Accepted
2024-10-13 2024-10-21 2024-11-01 2024-11-11 2024-11-21
Conflict of Interest Funding Ethical Approval Plagiarism X-checker Note
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© 2024by Kumari S, Sharma MMand Published by Maharshi Charaka Ayurveda Organization. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License https://creativecommons.org/licenses/by/4.0/ unported [CC BY 4.0].

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Download PDFBack To ArticleIntroductionAim and ObjectivesMaterials and MethodsObservations and ResultsDiscussionConclusionReferences
Sunita K et al. Haridradi Yog on Covid - 19 Recovered Patients of Madhumeha

Introduction

India has been using Ayurveda as a form of traditional medicine for centuries. The science of long life teaches people how to live a healthy lifestyle and prevents illness in addition to curing existing illnesses.

Madhumeha is considered by Ayurveda to be a typical cellular and tissue-level metabolic disease. This condition may be related to Dhatvagnimandya in Ayurveda. The current study is a humble attempt to treat Prameha patients according to classical principles.

Among endocrine diseases, Diabetes mellitus (DM) is one of the most prominent. It is a condition that affects the way carbohydrates, fats, and proteins are metabolized and is caused by an absolute or relative lack of insulin secretion together with variable degrees of insulin resistance.

Definition of Madhumeha

सर्व एव प्रमेहा मूत्रादिमाधुर्ये मधुगन्ध सामान्यात् पारिभाषिकीं मधुमेहाख्यां लभन्ते ।। (सु.चि.12/6)

It is a medical ailment termed Madhumeha in which the patient excretes urine that resembles Madhu, such as having a taste similar to Kashaya and Madhura, a colour similar to honey and body that becomes sweetness.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that causes the contagious sickness known as coronavirus disease 2019 (COVID-19). In Wuhan, China, in December 2019, authorities discovered the first recorded case. The illness soon spread throughout the world, causing the COVID-19 pandemic.

The Madhumeha (DM) are vulnerable to many bacterial & viral infections, they are more prone to be infected with the COVID-19. And after contracting with the COVID-19 they have experienced more aggravation in their symptoms like in pneumonitis etc. Many research studies have revealed that COVID-19 had the very bad effect on Madhumeha patients.

It was also observed in many research studies after the COVID-19 pandemic that there were more mortility rate in the patients of COVID-19 with the comorbidity of Madhumeha (DM).

Aim and Objectives

Therapeutic study to evaluate efficacy of Haridradi Yog in management of Madhumeha (Diabetes mellitus) patients, who recovered from COVID- 19.

Materials and Methods

Selection of cases

The study was conducted on 30 clinically diagnosed & confirmed cased of form OPD & IPD of associated group of hospital of M.M.M. Govt. Ayurved College, Udaipur irrespective of their age, sex, religion, occupation etc. Detailed history was taken and a special research pro-forma was prepared for the study incorporating all the relevant points from both Ayurvedic and Modern views.

Inclusion Criteria

1. The Patients of either sex in the Age group of 25 To 70 Years.
2. The Patients Having Clinical Sign and Symptoms of Madhumeha/Diabetes Mellitus.
3. Diabetic patients who recovered from the COVID-19 Infection.
4. Both Obese and non-Obese patients.

Exclusion criteria

1. Patients below 25 years & above 70 years of age.
2. Emergency cases in DM.
3. Patients having IDDM (Type 1).
4. Chronic complications (Microvascular & Macro vascular).
5. Patients who have not been infected with Covid-19.
6. with Juvenile Diabetes.

Selection of trial drug

Haridradi Yog (Hypothetical Ayurvedic Formulation)

Table 1: Show Ingredients of Haridradi Yog

SNSanskrit NameBotanical NameUseful PartQuantity
1.HaridraCurcuma longaRoot (rhizome)1 part
2.HaritakiTerminalia chubulaFruit1 Part
3.AmalakiEmblica officinalisFruit1 Part
4.BibhitakiTerminallia BillericaFruit1 Part
5.BilwaAegle marmelosLeaf1 Part
6.MaithiTrigonella FoenumgraecumSeed1 Part
7.JamunSyzygium cuminiSeed1 Part
8.DalchiniCinnamomum zeylanicumBark¼ Part
9.NeemAzadirechta indicaSeed¼ Part

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Sunita K et al. Haridradi Yog on Covid - 19 Recovered Patients of Madhumeha

Administration of Drug

Form: Churna
Dose: 5-5 gm with lukewarm water
Mode of administration: Oral
Time of administration: Before lunch and meal
Duration: 60 days

Study Design

Study type - Interventional.
Study design - A Single Arm, open labelled randomized clinical trial.

Follow-Up Study

Patient were followed up for 30 days to access the variation in symptomatology after completion of the therapy. Follow up progress and other effects were noted down.

Criteria for Assessment

Subjective assessment

Diagnosis was made on the basis of sign and symptoms of Madhumeha (Diabetes mellitus type- 2 Prabhoot Mutrata (Polyuria), Pipasa (Polydypsia), Bahuasheet (Polyphagia), Kara-Pada-Tala Daha (Burning sensation of hand and feet), Supti (numbness), Mutra Madhurya (Glycosuria), Avil Mutrata (Turbidity of urine).

Objective assessment

  • FBS
  • PPBS
  • Urine Test (Glucose, Albumin, Specific gravity, Urine colour) at an interval of 30 days.

These investigations were done in all the patients before treatment and after completion of treatment. For assessment of improvement in Clinical Manifestations following Symptom Rating Scale were used:

Table 2

SymptomsScore
Absent0
Mild1
Moderate2
Severe3

Observations and Results

Maximum no. of the patients i.e. 46.7% of the patients were from the age group of 61-70 years,

53.3% of patients were male patients, 83.3% of patients were married, maximum no. of patients were from Hindu religion (90%), maximum no. of patients i.e. 60% of patients were from weight group of 71-90 Kg, 70% of patients were having sitting type of work, 33.3% of patients were house wives, maximum number of patients (73.3%) of patients were from middle class, maximum number of patients (80%) were vegetarian, maximum number of patients (36.7%) were doing light and irregular Vyayama, 40% of patients were having Prabhut Nindra, 50 % of patients were having no family history, 43.3% of patients were having Vata- Pittaja Nadi, 76.7% of patients were having Samanya Gandha (normal smell), 56.7% of patients were having Malavrata (coated) Jivha, majority of patients 56.7% were having Vata-Kapha Prakriti.

Aaharja Nidana

In this study, 93.3% of patients were having Sheeta Dravya Sevana, 90% of patients were having Payanshi Sevana, 86.6% of patients were having Guru Ahara Sevana, 83.3% of patients were having Guda Vikara Atisevana, 80% of patients were having Madhura - Dravya Sevana, 73.3% of patients were having Snigdha Dravya Sevana, 70% of patients were having Atidadhi Sevana, 63.3% of patients were having Mutravardhaka Dravya, 50% of patients were having Navanna-Pana- Sevana, 43.3% of patients were having Ati-Amala-Lavana Ras and 23.3% of patients were having Gramyamamsaaati Sevana.

Viharaja & Mansik Nidan

In this study 80% of patients were having Asya – Sukham, 76.7% of patients were having Krodha, 73.3% of patients were having Avyayam & Shoka, 66.7% of patients were having Diwaswapana, 53.3% of patients were having Swapanasukham and 43.3% of patients were having Ratrijagran.

Impact of COVID - 19 on Madhumehi Patients

It was observed that 23.3% of patients reported no effect of COVID-19 on their disease condition. While, same proportion 23.3% reported weakness after suffering from COVID-19. Proportion of patients reporting shortness of breath was 20.0%, 10.0% reported joint pain, 6.7% reported sleeplessness, 6.6% reported Chest pain, 3.3% of the patients reported smell loss, joint pain & sleeplessness after COVID – 19.


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The results of the therapeutic trial:

Table 3: Showing Effect of therapeutic trial on clinical symptomatology in 30 patients of Madhumeha (DM Type-2)

Prabhut MutrataMeanSDMedianFirst quartileThird Quartile% changeZ-valuep-value
Before Treatment1.930.5212.002.002.0049.7%4.874<0.001 (*)
After Treatment0.970.4901.001.001.00Very Significant
Pipasa Adhikya
Before Treatment1.160.7461.001.002.0025.8%3.0000.001 (*)
After Treatment0.860.5071.001.001.00Statistically Significant
Kshudha Adhikya
Before Treatment1.630.8892.002.002.0026.3%3.1270.002 (*)
After Treatment1.200.8051.001.002.00Statistically Significant
Karpad Tala Daha
Before Treatment0.730.5211.000.001.0045.2%3.1620.002 (*)
After Treatment0.400.4980.000.001.00Statistically Significant
Supti
Before Treatment0.770.6261.000.001.0035.1%2.8280.005 (*)
After Treatment0.500.5720.000.001.00Statistically Significant
Mutramadhuryatah
Before Treatment0.47.6810.000.001.0057.4%2.8280.005 (*)
After Treatment0.20.4070.000.000.00Statistically Significant
Avila Mutrata
Before Treatment.60.7700.000.001.0061.6%3.3170.001(*)
After Treatment.23.4300.000.000.25Statistically Significant
Alasya/Utsahahani
Before Treatment0.930.5831.001.001.0067.7%4.146<0.001 (*)
After Treatment0.300.4660.000.001.00Very Significant
Daurbalya
Before Treatment2.370.7653.002.003.0034.1%4.347<0.001 (*)
After Treatment1.560.5042.001.002.00Very Significant
Pindiko-Udveshantan
Before Treatment.23.5040.000.000.0013.1%1.0000.317
After Treatment.20.4840.000.000.00Statistically No Significant
Compared using Wilcoxon sign rank test (*) denotes p-value is significant at 5% level of significance

Table 4: Showing effect of therapeutic trial on lab parameters in 30 patients of Madhumeha (DM-Type 2)

Fasting Blood Sugar (mg/dl)MeanStd. Deviation% changet-valuep-value
Before Treatment162.8042.64415.8%11.258<0.001 (*)
After Treatment137.0338.955Very Significant
Post Prandial Blood Sugar
Before Treatment223.4774.88815.3%7.498<0.001 (*)
After Treatment189.2064.028Very Significant
Urine Specific Gravity
Before Treatment1.0160.01030.19%3.3910.002 (*)
After Treatment1.0140.0097statistically Significant
Compared using paired sample t-test (*) denotes p-value is significant at 5% level of significance

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Discussion

Probable modes of action of Indigenous Formulation

Although Prameha is a Tridoshaja Vyadhi, the Acharyas focused primarily on the vitiation of the Kapha Dosha, Medovriddhi, and Medodhatwagnimandhya. Therefore, in Madhumeha patients, formulations that work at the level of Dhatwagni and oppose Kapha Dosha and Medodhatu are given in an effort to break down the Samprapti.

Most of the drugs in Haridradi Yog have Pramehara properties that affect Madhumeha's etiopathogenesis directly. It is possible that the qualities of Tikta-Katu-Kashaya Rasa, Laghu-Ruksha Guna, Ushna Virya, Katu Vipaka, and Deepan Paachan corrected Kapha Dushti and eliminated Medodhatwagnimandya, which corrected Medo Dhatu Dushti.

Additionally, they respond to Bahudrava Sleshma and Kleda, which are examples of Dosha Vishesha. Pitta vitiation may have been remedied by Tikta Rasa and Sheeta Virya Dravyas. Tridosha Shamaka drugs also alleviates Vata Dushti, resulting in regular functioning of Doshas and Dhatus. Alleviation of Kapha-Pitta removes obstruction from the path of Vata. As a result, Samprapti Vighatan takes place, the symptoms of Madhumeha are reduced.

According to modern pharmacology active principle of Haritaki, Vibhitaki, and Amalaki i.e., chebulinic acid which has reported alpa glucosidase inhibitory action, Vibhitaki also contains gallic acid which helps in regeneration of beta cells of pancreas, Amalaki stimulates pancreatic secretion, and restores and regenerates beta cell architecture, Haridra contains curcuminoids, have been shown to improve insulin resistance, decrease glucose and insulin levels, Fenugreek seeds also hypoglycemic in nature, Bilva Patra contain polyphenols and flavonoids, which can aid in the reduction of blood glucose level, Jamboline and jambosine, two active components found in the Jambu seeds, prevent the rate at which sugar is released into the blood and raise levels of the hormone insulin in the body, By simulating the actions of insulin and speeding up the absorption of sugar into cells, cinnamon may help decrease blood sugar and fight diabetes.

Conclusion

Prameha (Madhumeha) is a Tridoshajanya Vyadhi with a predominance of Kapha vitiation and metabolic disturbance at both Jatharagni and Dhatvagni levels. The major Dushyas of Prameha, Meda, Mamsa, and Kleda have been compared to type 2 diabetes' abnormal fat, protein, carbohydrate, and electrolyte metabolism. The alarming increase in prevalence of diabetes mellitus is caused by an excessively sedentary lifestyle, overeating, and overindulgence in fatty foods. The primary impacts of excessive Nidana of Prameha, specifically Aasyasukha, Swapnasukha, Avyayama, and Guru Snigdha Ahara, are vitiation of Kapha and Meda. Madhumeha should therefore be treated with medications that have Agnideepana, Amapachana, Kaphamedohara, and Anulomaniya characteristics. The absence of any harmful effects is a benefit for patients that is noticed in cases of Ayurvedic therapy, and it is especially important given widespread adoption of Ayurveda.

References

1. Charaka Samhita, Vidhyotini Vyakhaya, By Shir Satyanarayana Shastri, Published by Chaukhamba Bharti Academy Varanasi 2015.
2. Shusruta Samhita edited by Kaviraj Ambikadatta Shastri, Chaukhamba Sanskrit Sansthana, Varanasi, reprinted 2011.
3. Ashtanga Sangraha vidyotini edited by Kaviraj Atridev Gupta Chaukhambha Prakashana, Varanasi, 2009.
4. Ashtanga Hridaya vidyotini edited by Kaviraj Atridev Gupta Chaukhambha Prakashana, Varanasi, 2009.
5. The Bhavprakash nighantu with elaborated Hindi commentary by Padmashri prof. K.C. Chunekar, edited by Dr. G.S. Pandey, Chaukhambha Bharti Akadami, Varanasi, 2010.
6. Dravyaguna Vijanana Vol. II, Prof. P. V. Sharma, Chaukhambha Bharati Academy, Varanasi.

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