E-ISSN:2456-3110

Research Article

Siddartakadi Yoga

Journal of Ayurveda and Integrated Medical Sciences

2025 Volume 10 Number 1 JANUARY
Publisherwww.maharshicharaka.in

A clinical study to evaluate the therapeutic effect of Siddartakadi Yoga in Vishada w.s.r. to Depression

Korawar SR1*, Dhaneshwari HA2, Bhat VG3, Shrilatha KT4
DOI:10.21760/jaims.10.1.6

1* Soumya R Korawar, Post Graduate Scholar, Dept of Manovignana Evam Manasaroga, Sri Dharmasthala Manjunatheshwara College of Ayurveda Hospital and Research Centre, Udupi, Karnataka, India.

2 Dhaneshwari HA, Guie, Assistant Professor, Dept of Kayachikitsa and Manasaroga, Sri Dharmasthala Manjunatheshwara College of Ayurveda Hospital and Research Centre, Udupi, Karnataka, India.

3 Vijayendra G Bhat, Co-Guide, Associate Professor, Dept of Kayachikitsa and Manasaroga, Sri Dharmasthala Manjunatheshwara College of Ayurveda Hospital and Research Centre, Udupi, Karnataka, India.

4 Kamath T Shrilatha, HOD, Professor, Dept of Kayachikitsa and Manasaroga, Sri Dharmasthala Manjunatheshwara College of Ayurveda Hospital and Research Centre, Udupi, Karnataka, India.

Background: According to Ayurveda, both physical and mental health are equally important for an individual to be considered Swastha. Ayurveda explains that diseases can manifest as Shareerika (physical), Manasika (mental), or both. Vishada is a mental disease with psychosomatic consequences. "Siddharthakadi Yoga has been explained by Acharya Charaka in the context of Unmada Chikitsa (treatment of psychiatric disorders in Ayurveda).

Aims and Objectives: To evaluate the therapeutic effect of Siddartakadi yoga in Vishada (Depression).

Methodology: An open labelled clinical study with pre and post-test design. The 30 patients with diagnostic criteria of Vishada (Depression), were selected from Sri Dharmasthala Manjunatheswara Hospital of Ayurveda, Udupi, were subjected with 500mg capsule of Siddartakadi Yoga with Sukoshna Jala thrice after food for 30 days, follow-up was taken after 45days. All the parameters in subjective parameters were statistically analyzed with Wilcoxon signed rank and objective parameters by paired ‘t’ test.

Results: The effect of therapy was assessed with self-prepared Vishada Rating scale, Hamilton Depression Rating scale and WHO-QOL BREF Scale before and after treatment, have showed significant results.

Conclusion: Equally distributed gender of all age group, economic class and educational status were registered for the study, 1TID (Thrice a dose) of Siddartakadi Yoga. This shows no one is immune to Depression. Most of the subjects were of Vata-Kaphaja Prakruti and having Tamo/ Rajo Guna predominance who are prone for group of psychological imbalances. 30 days of treatment proved to be effective on Psychological, Somatic and Psycho somatic domains.

Keywords: Vishada, Siddhartakadi Yoga, Depression

Corresponding Author How to Cite this Article To Browse
Soumya R Korawar, Post Graduate Scholar, Dept of Manovignana Evam Manasaroga, Sri Dharmasthala Manjunatheshwara College of Ayurveda Hospital and Research Centre, Udupi, Karnataka, India.
Email: 		Korawar SR, Dhaneshwari HA, Bhat VG, Shrilatha KT, A clinical study to evaluate the therapeutic effect of Siddartakadi Yoga in Vishada w.s.r. to Depression. J Ayu Int Med Sci. 2025;10(1):40-49.
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Manuscript Received Review Round 1 Review Round 2 Review Round 3 Accepted
2024-12-14 2024-12-24 2025-01-04 2025-01-14 2025-01-27
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© 2025by Korawar SR, Dhaneshwari HA, Bhat VG, Shrilatha KTand Published by Maharshi Charaka Ayurveda Organization. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License https://creativecommons.org/licenses/by/4.0/ unported [CC BY 4.0].

J Ayu Int Med Sci 2025;10(1)40
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Soumya RK et al. Therapeutic effect of Siddartakadi Yoga in Vishada

Introduction

It is natural to experience a range of emotions, from happiness and sadness to anxiety and fear or even moments of forgetfulness and confusion. These emotional fluctuations are part of everyday life. Emotions are fundamental aspects of human experience.

However, when a person’s emotions, thoughts or behaviour consistently cause distress or disrupt their life and the lives of those around them, it could be a sign of mental illness. Despite the fact that approximately 1 in 5 people are believed to suffer from some or the other form of mental illness, it remains heavily stigmatized and often leads to discrimination.

As a result, many individuals hesitate to acknowledge they have a problem and delay seeking help or treatment. Sadly, untreated mental illness can lead to tragic outcomes, including suicide, which claims more than 720,000 lives annually, usually around the age 15-35. The economic burden of mental health conditions is also significant and continues to grow. Ayurveda places great importance on the mind and its disorders, recognizing their critical role in overall health.

Ayurveda, an ancient system of medicine, originated from the spiritual visions of Indian Rishis. It was developed through a gradual, step-by-step process by many sages. Ayurveda is a powerful tool provided by nature to help us understand, analyse, and cure diseases which are broadly classified into two types: Sharirika (physical) and Manasika (mental) disorders.

Regardless of exact origin of vedas, they hold a unique position by shedding light on early habits, customs, and medical science of nation. In fact, the Vedas serve as a foundation of Ayurveda, which emphasizes inseparable connection between body (Shareera), Mind (Manas) and Soul (Atma). This holistic integration forms basis of Ayurvedic philosophy, which views health as a dynamic balance of physical, mental and spiritual well-being. Ayurveda is considered as an Upaveda (Subtext) of Atharvaveda. According to Ayurveda, diseases are caused by an imbalance of three doshas- Vata, Pitta and Kapha. Treatment focuses on restoring balance to these doshas through lifestyle modification, dietary adjustments etc.

additionally, the Mind (Manas)being closely connected with the body (Shareera), plays a significant role in maintaining health, alongside the influences of the three Gunas- Satva, Rajas and Tamas. This dynamic balance between body, mind and spirit reflects Ayurveda’s holistic approach to healing, which not only addresses symptoms but also aims at preventing diseases by promoting overall harmony.

Ayurvedic literature gives equal importance to both physical and mental well-being, defining an individual in a state of health as “Swastha”- one whose established in the self, with balanced Doshas, Proper digestion (Agni), well-functioning of the senses (Indriyas) and a tranquil mind. In the context of disease (Athura), Ayurveda explains that ailments manifest primarily as either physical (Sharirika) or mental (Manasika) conditions or the combination of both.

The relationship between the Mind (Manas) and mental disorders (Manasika Vyadhis) has been scientifically explored across various texts in Ayurveda Literature, which detail how imbalances in the mind can directly influence the body and vice versa. Ayurveda continue to evolve, Bridging the ancient wisdom of natural healing with modern health practices.

In the present era this is applicable to all alternative systems of medicine. Psychiatric disorders described in Ayurveda thousands of years ago are relevant in present time too. Depression is such an area where many studies have been done and it is very well corelated with Vishada.[1]

Vishada is a state of mind or a disease caused by apprehension resulting in incapability of mind and retardation of psychomotor activities. It results in aggravation of ill health.[2]

Sanskrit dictionaries describe Vishada as the state of Dejection or despondency. The symptoms of Vishada are almost same as that of Depression. Modern dictionaries define that Depression one of several mood disorders marked by loss of interest of pleasure in living.[3]

Another dictionary describes that Depression means reduction of the level of functioning or a mental state or chronic mental disorder characterized by feelings of sadness, loneliness, despair, low self-esteem and self- approach.[4]


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Soumya RK et al. Therapeutic effect of Siddartakadi Yoga in Vishada

According to WHO, about 280 million people globally suffer from Depression, which accounts for approximately 3.8%of the population.[5]

This also includes 5% of adults Globally suffering from depression. World Health Organization defines Depression as “A common mental disorder, characterized by persistent sadness and a loss of interest or pleasure in activities that are normally enjoyable, accompanied by an inability to carry out daily activities, for at least two weeks.[6]

Depression is significant contributor to the Global burden of disease and affects people in all communities across the world. Depressive disorders often start at a younger age. They reduce people’s functioning and often are recurring.

For these reasons Depression is the leading cause of disability worldwide in terms of years lost due to disability. Vishada is considered one among the Vataja Nanatmaja Vikaras by Charaka. Sushrutha has classified Vishada as one among the Manasika Roga.

In this regard Vishada is a condition in which the mind and body is affected and the qualities of Siddartakadi Yoga can provide solutions for the problem by tackling with both Vata and Kapha Doshas also by balancing and improving psychological state of the individual. In this view of above said facts “A clinical study to evaluate the therapeutic effect of Siddartakadi Yoga in Vishada w.s.r. to Depression is planned.

Materials and Methods

Source of data

Patient source: Minimum of 30 patients fulfilling the inclusion, exclusion and assessment criteria from the OPD and IPD of Sri Dharmastala Manjunatheshwara College of Ayurveda, Hospital and Research Centre, Kuthpady.

Drug source: Cap. Siddartakadi Yoga were prepared and collected from SDM Pharmacy, Udupi.

Method of Collection of Data

A special proforma was prepared with all the points of preliminary data, history taking followed by assessing the signs and symptoms with Hamilton depression rating scale, WHO quality of life scale, Ayurvedic scale for assessment of Vishada.

Design of study: An open label single arm clinical study

Table 1: Showing the intervention and duration of the study

Intervention
Drug nameSiddartakadi Yoga capsule
Dose500mg capsule, TID
Route of AdministrationOral
Time of AdministrationMorning, Afternoon and night after food
AnupanaSukoshna Jala
Duration30 days
Duration of the study
Intervention30 days
Follow-up15 days
Total Duration45 days

Diagnostic criteria:

Subjects having the classical symptoms of Vishada, DSM 5 criteria, ICD10F33 criteria

Inclusion criteriaExclusion criteria
§ Patients fulfilling diagnostic criteria of Vishada w.s.r. to Depression.§ Subjects under pregnancy, lactation or below 18 years / above 60 years.
§ Age group from 18-60 years.§ Subjects having symptoms of Vata-Pittaja Unmada, Bhutonmada, Apasmara, Atatvabhinivesha.
§ Subjects willing to sign the informed consent.§ Subjects under other Psychiatric illness and complications of substance abuse.

Assessment criteria:

Classical symptoms of Vishada - Clinically assessed, Hamilton’s Depression rating scale, WHO quality of life scale before 0th day and after the treatment 30th day. And follow up was done on 45th day and the ratings were noted.

Subjective parameter:

  • Hamilton scale for Depression
  • WHO- BREF quality of life scale
  • Vishada rating scale (self-assessed)

Frequency of Abnormalities - Gradings for assessing the parameters

FrequencyBTAT
Never - 0
Occasionally - 1
Sometimes - 2
Frequently - 3
Constantly - 4

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Table 4: Classical symptoms of Vishada

1. UdvignataIntensity of feeling tense/ irritable/ uneasiness
2. ApravrittiUnable to have continuous flow in life/ active life
3. SadaIntensity of experiencing misfortune/bad or unhappiness of things that make you feel sad.
4. AprayatnaAbsence of effort / not endeavouring
5. AshabhangaDefeat of hope/ disappointment
6. AlpavakIn conversable/ restrained/ closemouthed
7. BhayaFear of danger/ distress
8. Hastapada KampaShivering of hands& feet out of danger/ in fear of happening
9. Alpa ChestaLimited effort/ desire/ wishes
10. AtinidraExcessive sleeping/ desire to keep sleeping
11. AnannabhilashaReduced appetite/ not interested towards having food
12. ShokaSorrow/grief/ deep anguish
13. NirasaFeeling of hopeless, despair or freedom from desire.
14. Alpa NidraReduced/ disturbed sleep

Objective criteria: Routine Blood investigations (If required)

Results

In the current study, 30 patients of Vishada / Depression were registered and administered 1 capsule of Siddartakadi Yoga were given thrice a day as divided dose of 500mg once in the morning, afternoon and night after food with warm water for total 30 days, in this single group and also pre-test post-test clinical trial was done. The effect of the treatment following medication was assessed. The parameters were analysed statistically using Paired ‘t’ test and Wilcoxon sign rank test with help of sigma statistics software. The details of the same are elaborated in this section on results.

Effect on Utsahanasha

Administration of Siddartakadi Yoga capsules was found to be effective in symptom Utsaha Nasha. Among all the 30 patients, the mean score prior to the treatment was 2.033 which decreased to 0.767 after the treatment with mean difference of 1.266.

The analysis by applying the Wilcoxon signed rank test showed that the improvement was statistically highly significant with ‘P’ value of P<0.001. Details are shown at full length in the table (table no. 5) and figure (fig no. 1). The mean score on before treatment 0th, 30th (after treatment), 45th (follow-up) day of treatment is shown in line diagram. Figure no. 2.

Table 5: Utsaha Nasha

BTATBT-AT% of improvementSDSEMMedianZvaluePvalue
2.0330.7671.26662.27BT-1.2730.4752.0004.388<0.001
AT-0.5680.2121.000

Jaims_3964_01.jpg
Figure 1: Utsaha Nasha

Jaims_3964_02.jpg
Figure 2: Utsaha Nasha

Effect on Apravritti

Administration of Siddartakadi Yoga capsules was found to be effective in symptom Apravritti. Among all the 30 patients, the mean score prior to the treatment was 2.200 which decreased to 0.997 after the treatment with mean difference of 1.203.

The analysis by applying the Wilcoxon signed rank test showed that the improvement was statistically highly significant with ‘P’ value of P<0.001. Details are shown at full length in the table (table no. 6) and figure (fig no. 3). The mean score on before treatment 0th, 30th, (after treatment), 45th (follow-up) day of treatment is shown in line diagram. Figure no. 4.


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Table 6: Apravritti

BTATBT-AT% of improvementSDSEMMedianZvaluePvalue
2.2000.9971.20354.68BT-0.9970.3722.0004.573<0.001
AT-0.5710.2131.000

Jaims_3964_03.jpg
Figure 3: Apravritti

Jaims_3964_04.jpg
Figure 4: Apravritti

Effect on Sada:

Administration of Siddartakadi Yoga capsules was found to be effective in symptom Sada. Among all the 30 patients, the mean score prior to the treatment was 2.767 which decreased to 1.067 after the treatment with mean difference of 1.7.

The analysis by applying the Wilcoxon signed rank test showed that the improvement was statistically highly significant with ‘P’ value of P<0.001. Details are shown at full length in the table (table no. 7) and figure (fig no. 5).

The mean score on before treatment 0th, 30th, (after treatment), 45th (follow-up) day of treatment is shown in line diagram. Figure no. 6.

Table 7: Sada

BTATBT-AT% of improvementSDSEMMedianZvaluePvalue
2.7671.0671.761BT-0.9350.3493.0004.635<0.001
AT-0.5210.1941.000

Jaims_3964_05.jpg
Figure 5: Sada


Jaims_3964_06.jpgFigure 6: Sada

Effect on Asiddhi Bhaya:

Administration of Siddartakadi Yoga capsules was found to be effective in symptom Asiddhi Bhaya. Among all the 30 patients, the mean score prior to the treatment was 1.533 which decreased to 0.733 after the treatment with mean difference of 0.8.

The analysis by applying the Wilcoxon signed rank test showed that the improvement was statistically highly significant with ‘P’ value of P<0.001. Details are shown at full length in the table (table no. 8) and figure (fig no. 7) The mean score on before treatment 0th, 30th, (after treatment), 45th (follow-up) day of treatment is shown in line diagram. Figure no. 8


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Soumya RK et al. Therapeutic effect of Siddartakadi Yoga in Vishada

Table 8: Asiddhi Bhaya

BTATBT-AT% of improvementSDSEMMedianZvaluePvalue
1.5330.7330.852.1BT-1.2790.4781.0003.900<0.001
AT-0.8680.3241.000

Jaims_3964_07.jpg
Figure 7: Asiddhi Bhaya

Jaims_3964_08.jpg
Figure 8: Asiddhi Baya

Effect on Hamilton Depression Rating Scale: Administration of Siddartakadi Yoga capsules was found to be effective in symptom Hamilton Depression rating scale. Among all the 30 patients, the mean score prior to the treatment was 19.90 which decreased to 9.00 after the treatment with mean difference of 10.8.

Table 9: Hamilton Rating Scale

MeanWilcoxon signed rank test
BTATBT-AT% of improvementSDSEMMedianZ valueP value
19.809.0010.854.54BT-3.8361.43319.504.797<0.001
AT-3.5331.3199.50

The analysis by applying the Wilcoxon signed rank test showed that the improvement was statistically highly significant with ‘P’ value of P<0.001.

Details are shown at full length in the table (table no. 9) and figure (fig no. 9).

Jaims_3964_09.jpg
Figure 9: Hamilton Rating Scale

Effect On Vishada Rating Scale

Administration of Siddartakadi Yoga capsules was found to be effective in symptom Vishada rating scale. Among all the 30 patients, the mean score prior to the treatment was 16.567 which decreased to 7.433 after the treatment with mean difference of 9.134. The analysis by applying the Wilcoxon signed rank test showed that the improvement was statistically highly significant with ‘P’ value of P<0.001. Details are shown at full length in the table (table no. 10) and figure (fig no. 10)

Table No:10 Effect on Self Assessed Vishada Rating Scale

MeanWilcoxon signed rank test
BTATBT-AT% of improvementSDSEMMedianZ
value		P
value
16.5677.4339.13455.133BT-3.6551.36516.0004.793<0.001
AT-2.6610.9947.500

Jaims_3964_10.jpg
Figure 10: Showing Vishada Scale


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Soumya RK et al. Therapeutic effect of Siddartakadi Yoga in Vishada

Over All Assessment in Response to Treatment

In the study 0% had excellent improvement, 70% had marked improvement, 30% had mild improvement, 0% had a poor improvement. Details are shown at full length in the table (table no. 11) and figure (fig no. 11).

Table 11: Showing overall improvement

SNImprovementScaleNo. of Patients% of Patients
1.Excellent75-100%13%
2.Marked50-75%2270%
3.Mild25-50%727%
4.Poor0-25%00%

Jaims_3964_11.jpg
Figure 11: Showing overall improvement

Among the 2 assessment parameters which are taken for the study, i.e., HAM-D scale and Vishada scale there were marked improvement in between 50-75% and some are having mild improvement which lies between 25-50% results and there was also excellent result that is from 75-100%.

Discussion

Vishada is one of the Nanatmaja Vyadhi (Vataja). Vishada is the main factor which is the reason for increasing or causative factor for diseases. The symptoms or the detail description of Vishada are very scattered in our classics. This condition is also neglected sometimes and in recent times the increasing rate of psychological issues and the impact of these factors on physical health are concerning. Understanding Vishada and exact co relation of symptoms of Vishada can be done with Mild to moderate Depression. The present clinical study was aimed to evaluate the efficacy of Siddartakadi Yoga in the management of Vishada/ Depression.[7]

Vishada is one among the Vataja Nanatmaja Vikara and also described as Manasika Vikara in Ayurveda literature. Texts describe Vishada as a state with loss of interest and inactivity in any works which is resultant of the fear of failure. In depression the mood or effect of the individual are derailed. The condition will be characterized by mood of extra ordinary sadness and dejection with depressed mood, pessimistic thinking, reduced energy and psychomotor retardation. Depressive disorder, a mood disorder which is characterized by depressed mood, anhedonia, decreased energy, fatigability, lack of emotional reactivity, loss of libido, anxiety, agitations, sleep disturbances, psychomotor retardation and other symptoms affecting the body and mind. The causes of depressive disorders can be classified as biological, psychological and social factors. Biological includes genetic, endocrine and other physiological and pathological changes happening in the body. Psychological factors explained by various philosophers in terms of “learned helplessness”, cognitive theories like negative thoughts, nihilistic ideas; “mourning & depression” by Sigmund Freud etc. Social factors include lack of social relationship, insecurity, loneliness; life events like loss of spouse, unemployment, natural or artificial disasters etc. Some people’s emotional responds in a situation tend to develop negative thought process like lack of initiative, anhedonia (inability to experience pleasure or indulge in previously pleasurable activity), social withdrawal etc, which can consider termed as “Depression” in a medical context means state of extreme dejection. “Vishada” according to dictionary also has explained it as state of depression and dejection.

Vata is the Dosha which is vitiated in Vishada. The Karma (function) of Vata can be seen impaired in this condition. This may be the reason why it is included under Vata Nanatmaja Vyadhi by Charaka. Psychomotor activities are seen in a depressive patient, thus can be concluded as the Karmahani of Vata Dosha. Vishada has been explained as a characteristic feature of Tamasik Guna “Tamasastu Vishaditvam” which can be considered as the psychological cause in Ayurveda. The symptoms as found in the context of Vishada in Bhagavad Geeta provides an idea regarding the psychological and social factors causing depressive disorders thus resulting in state of helplessness in person which is presented along with physical symptoms too.


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The state of Avasada explains about the psychomotor retardation very clearly, which is one of the main symptoms seen in depressive disorder. Vishada is explained in terms of apprehension and fear of failure which can be correlated to a state of mind in the person which is observed in the initial stages of depressive disorders. The four main symptoms needed to consider the disease as depressive disorder according to DSM IV are Depression, anhedonia (lack of interest in indulge in activities which were previously pleasurable), decreased energy, fatigability. These four symptoms are clearly described in Bhagavad Geeta in the previously mentioned context.

Psychic Symptoms: Dukhita (distressed, unhappy, grieved in mind) Avasada (hoplessness, lassitude), Manah Khedah (feeling of depression), Vishanna (dejection, sorrow), Chitta Glani (fatigue of mind), Asiddhi Bhaya (fear and anxiety or apprehension of failure), Dainya (miserable state/depression), Chittodvega (Anxiety), Feeling of inadequacy, Thought of death/suicide. Somatic Symptoms: Sidanti (loosening of muscles), Mukha Shosha (Dryness of mouth), Prasveda (Exessive sweating), Bhramati Manas (Wandering mind), Tvak Paridaha (Burning sensation of skin), Vepathu (Tremor), Roma Harsha (horripilation), Sransanam (Inability to hold). The symptoms of Vishada which were found in various references in Indian Science when compared to depressive disorders almost appear similar. The above given psychic and somatic symptoms prove it on studies. The understanding and diagnosis of depressive disorders even in the modern science is based on either ICD or DSM. Both the two systems have emphasized on different symptoms in their respective diagnostic criteria and have stated those as symptoms which must be seen in the patient to consider it as depressive disorder. These prime symptoms when taken into consideration can be seen similar as the symptoms of Vishada itself. The Bhagavad Geeta reference says about the individual not interested in doing activity which he used to enjoy previously, this is specifically anhedonia which is seen as a main symptom in depressive disorder, again supported by other features of decreased energy, fatigability and depressed mood as found both in Vishada and depressive disorder. Based on the explanations given above, the condition Vishada can be interpreted and understood on the basis of depressive disorder.

A lot of symptoms can be found similar in both the conditions and thus providing a justification that both can be considered same, though has been explained in different schools of thought. Even in the modern science depressive disorders is explained with different views based on the understandings of various scholars. Specific criteria for diagnosing a condition as depressive disorder are still confusion. At this point of time Depressive disorders can be considered as Vishada according to the Ayurveda understanding. The present clinical study aimed to evaluate the efficacy of Siddartakadi Yoga in Depression was done to gain the familiarity on management of Depression through Ayurveda drugs, as it is one of the common mental diseases in present era and also todays need to focus. And the marked results were obtained. Vishada is one of the Nanatmaja Vyadhi (Vataja). Vishada is the main factor which is the reason for increasing or causative factor for diseases.

The symptoms or the detail description of Vishada are very scattered in our classics. This condition is also neglected sometimes and in recent times the increasing rate of psychological issues and the impact of these factors on physical health are concerning. Understanding Vishada in contemporary science makes it more understandable and in detail. Exact co relation of symptoms of Vishada can be done with Mild to moderate Depression. This condition is also neglected sometimes and in recent times the increasing rate of psychological issues and the impact of these factors on physical health are concerning. Understanding Vishada in contemporary science makes it more understandable and in detail. The symptoms of Vishada can be best matched with Mild to Moderate Depression.[8]

The trial drug used for the present study was Siddartakadi yoga. Siddartakadi Yoga formulation has been taken from Charaka Samhita, and also available in Yogaratnakara. In this study, the formulation from Yogaratnakara has been selected and this formulation consist of Kaphahara, Vatahara and tridoshahara properties helps to reduce the complaints of Vishada. So, this was the choice of drug in the management of Vishada/ Depression.[9] The formulation mainly consists of 17 drugs like Siddartaka, karanja, Vacha, Hingu, Devadaru, Manjista, Haritaki, Vibhitaki, Amalaki, Katabhitwak(Jyotishmati), Shunti, Maricha, Pippali, Priyangu, Shirisha, Haridra, Daruharidra.


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Most of the drugs are having Kapha-Vatahara Properties and having Laghu-Rooksha-Teekshna-Sukshma Gunas and also have Katu-Tikta-Kashaya Rasa and have Ushna Veerya (some have Sheeta), Madhura and Katu Vipaka.

Which also acts like a Deepana-Pachana. As the Doshas mainly here gets Prakopa are Vata (Sharirika) and Rajas (Manasika) mainly in Vishada and these Prakupita Doshas get seated in Manas Sthana i.e., Hrudaya and causes Vibhrama Manas leading to Mano Avasada which leads to disease causation.

Agni Deepana action is one of the main properties of many drugs in the formulation used. All the diseases basically originated by Mandagni according to Ayurveda. As the patients may have Viruddha- Dushta Ahara which is also a causative factor for causing of the disease. The probable mode of action of Siddartakadi Yoga, based on the Rasa, Guna, Karma, Virya, Vipaka and Prabhava of drugs in it.[10]

After 30 days of treatment, over all response of the drug on signs and symptoms were collectively presented here in a nut shell. In the study 70% had marked improvement, 30% had mild improvement, 0% had excellent improvement, 0% had a poor improvement. Overall response based on the signs and symptoms is statistically significant in the present study. Almost all the patient showed an improvement in all symptoms.

Conclusion

Out of 30 patients of Vishada (Mild Depression) studied in this study, maximum number of patients belonged to the age group 30-40years, gender female, religion Hindu, marital status married, educated up to high school, socio-economic status middle class, occupation most of them were house wife, dietic habits were mixed, Agni was Vishmagni and Krura Kosta. Siddartakadi Yoga was found to be beneficial in 30 days of treatment. There were significant results noted in Ayurveda parameters of self-prepared Vishada rating scale (self-assessed). The drug can prevent further severity of the disease as Depression is an ailment which progress from mild to severe. The parameters of Hamilton’s Depression rating scale also showed significant results in total score after 30 days of the treatment.

Study can be concluded that the drug used here, Siddartakadi Yoga could reduce the Vata and Kapha Doshas along with that maintains the normalcy of Mano Doshas as well. No any adverse drug reaction was seen on the subjects after intake of the medicine.

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