Introduction

Immunity deals with both identifying foreign compounds and inactivating and rejecting bacteria and other foreign chemicals.^[1] The failure of ability to distinguish between the body's own tissue and foreign body at some point is likely the fundamental component of Autoimmune disorders.^[2]

Due to changes in lifestyle, the prevalence of Autoimmune illnesses such as Rheumatoid Arthritis, Pemphigus vulgaris and Systemic Lupus Erythematosus, etc. is on the rise. Substances that alter or control immunological processes are known as Immunomodulators. Immuno modulators are used in a number of medical disorders to either suppress an overactive immune system, as in autoimmune diseases, or strengthen it when it is weak, like in some infections or cancers. Ayurveda, an Indian system of medicine, offers a lot of promise for treating Autoimmune Diseases.

We have a lengthy history of success addressing the underlying cause of the illness rather than its symptoms through Ayurveda. Ayurveda approaches the root cause of any disease and not merely the symptom. Inflammatory changes mainly occur due to Ama.^[3] Mandagni is the root cause of Autoimmune Disorders. Consequently, the goal of Ayurvedic treatment is to restore Jatharagni. Jara (Rasayana) Chikitsa is one among the Astanga Ayurveda Explained by Vaghbhata.^[4]

Discussion

Mode of Action of Rasayana Dravyas

Rasayana medications have been shown to be Saptadhatuvardhana; nevertheless, in order to be Saptadhatuvardhana, the following conditions must be met:

1. Make sure that all of the body's systems are operating physiologically.
2. In order for the nutrient fraction to reach every Srotasa correctly and consistently, it is necessary to comprehend the physiological Gati of Apan Vayu.
3. Agni's typical physiological activity ensures that the nutritional fraction consistently and correctly reaches all

Mode of action of Bhallataka as Rasaya

Bhallataka Madhura Vipaka & Snigdha Guna

Katu, Tikta, and Kashaya Rasa Saptadhatuvardhana
↓
Deepan, Pachana, Bhedaniya especially Shukravardhaka
↓
Works on Jatharagni Vyadhishkamatwa Rasayan
↓
Decreases Margavrodha (Laghu, Ruksha, Aashu, Vishad, Vyavayi, Teekshna & Ushna Guna)
↓
Removes Ama from Srotas (Srotoshodhana)
↓
Increases Rasa- Rakta Samvahana in body (Micro-circulation & Bioavailability)
↓
Removes Dhatvagni Mandya
↓
Improved Quality of Dhatus
↓
Immunity → Rasayana

Antioxidants Property:^[16]

The antioxidant activity of the aqueous extract of the nuts of the medicinal plant SA was examined by Verma et al. in the liver of AKR mice while lymphoma developed.

Antioxidant enzyme activities rise when the aqueous extract of SA is administered to lymphoma-transplanted mice, whereas LDH activity sharply declines, suggesting a reduction in carcinogenesis.

At 0, 1, 2, and 3 hours following therapy, blood glucose levels were assessed, and the antihyperglycemic effect of SA was contrasted with that of tolbutamide, a sulfonyl urea derivative used to treat diabetes mellitus.

The primary goals of Ayurveda are to preserve a healthy individual's health and treat a sick person's. The distinctive idea of Ayurveda is called Rasayana, or Rejuvenation. In Sheet Kala, Bhallataka can be used as an Immunomodulator to prevent disease; as Naimittika Rasayana, it can be used to treat Autoimmune illnesses.

Conclusion

The potential of Bhallataka as an Immunomodulator in Autoimmune illnesses is highlighted in this review. The herb is a promising adjuvant therapy for Autoimmune Disorders because of its capacity to control Immune cell function, cytokine synthesis, and Antioxidant defenses.

Though more investigation is required to completely comprehend its mechanisms and effectiveness in human. The data that is now available indicates that Bhallataka might be a useful supplement to the conventional therapy regimen for autoimmune diseases.

References