E-ISSN:2456-3110

Review Article

Alcoholism

Journal of Ayurveda and Integrated Medical Sciences

2025 Volume 10 Number 6 JUNE
Publisherwww.maharshicharaka.in

A Review on “Sarva Madahar Leha Yoga” An Ayurvedic Formulation in Madatyaya (Alcoholism)

Soliya V1*, Shukla U2, Rathi S3, Malviya A4
DOI:10.21760/jaims.10.6.42

1* Vijay Soliya, Post Graduate Scholar, Department of Agad Tantra Evum Vidhi Vaidyaka, Pt Khushilal Sharma Government Ayurveda College and Hospital, Bhopal, Madhya Pradesh, India.

2 Urmila Shukla, Professor, Department of Agad Tantra Evum Vidhi Vaidyaka, Pt Khushilal Sharma Government Ayurveda College and Hospital, Bhopal, Madhya Pradesh, India.

3 Sharad Rathi, Lecturer, Department of Agad Tantra Evum Vidhi Vaidyaka, Pt Khushilal Sharma Government Ayurveda College and Hospital, Bhopal, Madhya Pradesh, India.

4 Anshu Malviya, Lecturer, Department of Agad Tantra Evum Vidhi Vaidyaka, Pt Khushilal Sharma Government Ayurveda College and Hospital, Bhopal, Madhya Pradesh, India.

Madatyaya is characterized by excessive alcohol consumption, symptoms include, thirst, confusion, headache, numbness and disturbed mortar coordination. Alcohol abuse or excessive alcoholism known as Madatyaya in Ayurveda, it not only harms the health of individual but also impacts social and economic wellbeing of family. Madatyaya is categorized as a lifestyle disorder or addictive disorder, its prevalence increases globally due to the modern pattern of life style. Madatyaya affects Hridaya, Rasavaha srotas, Manovaha srotas and Oja, etc. Ayurvedic treatment approach for managing Madatyaya. The treatment involves a combination of physical, mental, and spiritual therapies to help individuals overcome addiction and achieve overall well-being.

Objective: The objective is to explore the pharmacological properties of the individual components of Sarva Madahar Leha Yoga and evaluate their collective impact on Madatyaya.

Method: Various databases, including Google Scholar, PubMed and Ayurvedic journals, were searched using relevant keywords. Studies reporting on the antimicrobial activity, hepatoprotective activity, antifungal activity, and immunomodulatory activity of the individual components of Sarva Madahar Leha Yoga were included. Ayurvedic Samhita and Nighantu with commentaries are used for relevant content. Data were synthesized to elucidate the potential mechanisms of action and therapeutic efficacy of Sarva Madahar Leha Yoga in managing Madatyaya.

Keywords: Sarva Madahara Leha Yoga, Madatyaya, Alcoholism, Kapittha, Dadima, Draksha

Corresponding Author How to Cite this Article To Browse
Vijay Soliya, Post Graduate Scholar, Department of Agad Tantra Evum Vidhi Vaidyaka, Pt Khushilal Sharma Government Ayurveda College and Hospital, Bhopal, Madhya Pradesh, India.
Email: 		Soliya V, Shukla U, Rathi S, Malviya A, A Review on “Sarva Madahar Leha Yoga” An Ayurvedic Formulation in Madatyaya (Alcoholism). J Ayu Int Med Sci. 2025;10(6):308-313.
Available From
https://jaims.in/jaims/article/view/4078/

Manuscript Received Review Round 1 Review Round 2 Review Round 3 Accepted
2025-05-08 2025-05-26 2025-06-06 2025-06-16 2025-06-26
Conflict of Interest Funding Ethical Approval Plagiarism X-checker Note
None Nil Not required 12.36

© 2025 by Soliya V, Shukla U, Rathi S, Malviya A and Published by Maharshi Charaka Ayurveda Organization. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License https://creativecommons.org/licenses/by/4.0/ unported [CC BY 4.0].

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Download PDFBack To ArticleIntroductionDrug ReviewDiscussion and ConclusionReferences
Vijay S et al. A Review on “Sarva Madahar Leha Yoga” An Ayurvedic Formulation

Introduction

Madatyaya, as described in Ayurveda, is a condition characterized by the excessive and improper consumption of alcohol leading to physical & mental deterioration. According to Ayurvedic principles, alcohol consumption in supervision of physician may have therapeutic effects, but when consumed excessively and in wrong manner, it disturbs the equilibrium of the doshas within the body. This imbalance can manifest in various symptoms and complications associated with alcoholism. It is not solely seen as a physical ailment but also as a disturbance in mental health and spiritual well-being. Ayurvedic texts emphasize the importance of addressing the root causes of alcoholism and restoring balance of the entire system. The excessive and improper intake of Madya cause poisonous impact on our body. In Madatyaya patients shows symptoms like headache, tremor, delirium, diarrhoea, anorexia, hallucination etc. and the Chikitsa of Madatyaya including Sanshodhan, Sanshman, Harshani Chikitsa, Manochikitsa and Ayurveda formulation like Kharjuradi Manth, Mradvikadi Kashaya, etc. As we know the impact of alcohol on social, economical, occupational aspect of life including physical and mental health. It is a prime need to reestablish the efficacy of Ayurvedic formulation on Madatyaya in the current era.

Drug Review

Sarva Madahar Leha Yoga is a herbal formulation used for the management of Madatyaya. It has been described by Acharya Mahamati Cakrapanidas in Abhinav Chintamani - first part. Its primary constituents include Kapittha, Dadima, Draksha in equal quantity.

Kapittha

Botanical name: Feronia limonia
Family: Rutacea
Main Synonym: Dadhittha, Pushpaphala, Kapipriya, Dantashadha

Regional name

GujaratiKothu
HindiKaitha
KannadaVelalu
TamilBakamaram
EnglishElephant apple, Wood apple

jaims_4078_01.JPG

Classification (Gana)

Bhavaprakasha Nighantu - Aamradi Phala Varga
Kaiydeva Nighantu - Aushadhi Varga, Krittan Varga
Useful parts - fruit, flower, root

Rasa Panchak

Rasa PanchakRipe pulpUnripe pulp
RasaMadhur, Kashaya, AmlaAmla, Kashaya
GunaLaghuGuru
ViryaShitaUshna
VipakMadhurAmla
Dosha shamakataTridoshaharaKaphaghna, Vatpittakrat

Formulations (Yoga): Kapitthastaka Churna

Chemical composition: Fruit pulp contains planty citric acid and mucilage. Dried pulp of fruit contains citric acid ranging up to 15 percent. Ash contains potassium, calcium and iron salts. Ash is deliquescent in humidity. Leaves contain O.73 volatile oil which is also present like leaves of Aegle marmelos (L.) Correa. (Bilva).

Scientific Studies

Antimicrobial activity[1]

One of the major causes of morbidity and mortality in immune compromised patients is pathogenic microorganisms. Microorganisms like bacteria tend to become resistant to drugs, coupled to side effects of some antibiotics. This invites a vital need to control microbial infections using appropriate antimicrobials devoid of side effects.

There is evidence that the ethanolic extract of wood apple leaves showed antibacterial activity against variety of bacteria such as Shigella boydii, Shigella dysentery and Shigella flexneri and demonstrated the reduction in severity and frequency of diarrhoea (Bellah et al., 2015).


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Hepatoprotective activity[2]

In study aimed to evaluate hepatoprotective potential of methanolic extract & of marmesin isolated from root bark of wood apple. Activity levels of aspartate aminotransaminase (AST) & alanine aminotransaminase (ALT), cell viability & cell death were evaluated in Hep G2 cells (human liver hepatoma cells) treated with CCl4 in presence or absence of wood apple extract or marmesin. It was found that in‐vitro co‐supplementation of methanolic extract or marmesin significantly minimized alteration in levels of AST & ALT & improved cell viability. Oral administration of methanolic extract or marmesin significantly prevented CCl4‐induced elevation in plasma markers of hepatic damage & hepatic lipid peroxidation & decrease in hepatic antioxidants. In‐vivo hepatoprotective potential of methanolic extract & marmesin was evident from minimal alterations in histoarchitecture of liver.

Anti Diarrhoeal activity

Plants have various useful chemical constituents which are used in the treatment of diarrhea.[3] The antidiarrhoeal activity and gastrointestinal motility reducing activity of alcoholic and aqueous extract of bark of Feronia limonia, was evaluated. In the gastrointestinal motility test, the both extracts, showed antidiarrhoeal activity in the concentration of 200mg/kg compared with the control group. Ethanolic extract showed a significant antidiarrhoeal activity and significantly decreased the propulsion of charcoal meal through the gastro intestinal tract.[4]

Antifungal Activity[5]

The different extracts (petroleum ether, chloroform, methanol and aqueous) of Feronia limonia Linn fruit pulp exhibited antifungal activity against some pathogenic fungus.

Dadima

Botanical name:Punica granatum
Family: Punicaceae
Main Synonym: Dantabija, Karaka, Lohitpushpaka, Kuttima, Sukavallabha, Nilapatra, Phalamla, Kuchphala.

Regional name

GujaratiDadam
HindiAnar, Dadima
TamilMadalai, Madalam
TeluguDalimbakaya
EnglishPomegranate

jaims_4078_02.JPG

Classification (Gana)

Charak Samhita - Hridya and Chardinigrahana Mahakashaya
Sushruta Samhita and Acharya Vagbhatta - Parushakadi Gana
Useful parts - fruit-seeds, fruit-pericarp, roots bark.

Rasa Panchak

RasaMadhur, Kashaya, Amla
GunaLaghu, Snigdha
ViryaAnusna
VipakMadhur
Dosha ShamakataTridoshaghna

Formulations (Yoga): Dadimastaka Curna, Dadimadi Curna, Dadimadya Ghrita, Dadimadya Tail

Chemical composition: Fruit contains sugar 15 percent, pectin and other substances. Root contains liquid alkaloid pelleterisne; it also contains two inactive alkaloids.

Bark yields alkaloid pelleterine. Rootbark contains four alkaloids - pseudo-pelleterine, palleterin, isopelleterine and methylpelleterine. Stembark and Pericarp (fruit) contains tannin 22-25 per-cent and root bark punico-tannic acid 20-25 percent.

Scientific Studies

Anthelmintic activity[6]

Anti helmintic activity of Punica granatum was studied by Singhal KC, he reported that the chloroform extract of dried root and stem, administered to mice by gastric intubation at a dose of250.0 mg/ kg for 3 days, was active on Hymenolepsis nana and inactive on Nippostrongylus brasiliense and syphacia obvelata.


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Anti diabetic effect[7]

A study was carried out to investigate the antidiabetic effect in flowers by Jafri MA. et al. They revealed that ethanol extract of the male abortive flowers, administered orally to normal glucose fed hyperglycaemic, and alloxan induced diabetic rats, produced significant blood glucose lowering effect.

Immunomodulatory Activity

A study was carried out to investigate the immunomodulatory activity of Anar by Ross G et al. that aqueous suspension of fruit rind powder, administered orally to rabbits at a dose of 100 mg/kg, stimulated the cell-mediated and humoral components of the immune system. There was an increase in antibody titre to typhoid-H antigen.

Antifungal activity[8]

Dhavan B. et al. reported the antifungal activity of Punica granatum in Ethanol/water (1:1) extract of aerial parts, at a concentration greater than 25.0 mcg/ml on agar plate, was inactive on Microsporum canis, Tricophyton menta grophytes, and Aspergillus nigar.

Draksha

Botanical name: Vitis vinifera
Family: Vitaceae
Main Synonym: Mrudwika, Gostani, Rasala, Guda, Swaduphala, Madhuyoni, Madhurasa, Brumhani, Charuphala.

Regional name

GujaratiDraksh
HindiAngoor
TamilKottai thiratchai
TeluguDraksha
EnglishGrapes

jaims_4078_03.JPG

Classification (Gana)

Acharya Sushruta and Vagbhatta - Parushakadi Gana
Acharya Charak - Kanthya, Virechanopag, Kasahara, Shramahara Mahakashay
Useful parts - Fruit

Rasa Panchak

RasaMadhur
GunaSnigdha, Guru, Mradu
ViryaShita
VipakMadhura
Dosha ShamakataVatapittasamaka

Formulations (Yoga): Draksarista, Draksadi Kvatha, Draksadi Leha, Kanakasava, Draksadya Ghrata, Pippalyasava.

Chemical Composition: Fruit juice contains malic, tartaric, and racemic acid, along with 0.05 percent of ash. Fruits contain glucose and other substances.

Scientific Studies

Hepatoprotective effect

The polyphenol compounds found in grape skin extract could improve hepatic steatosis and adiposity in high-fat-diet mice by regulating mRNA expression (changing lipogenesis and β-oxidation genes).[9] Grape seeds extract was able to guard liver injury caused by alcohol induction. Grape seeds extract administered to rats induced by 20% ethanol in rats could decrease AST and LDH.[10] In rats induced by paracetamol treated by grape dried seed, the ALP level could be reduced.[11]

Antihypertension activity

Skin grape aqueous extract (Vitis vinifera L.) could prevent increasing systolic blood pressure in spontaneously hypertensive rats measured using tail-cuff method. Results demonstrated that hypertensive rats had blood pressure > 200 mmHg & hypertensive rats treated with grape skin extract had blood pressure < 150 mmHg.[12] Godse et al. (2010) stated that myricetin content found in grape raisin could reduce systolic blood pressure in fructose-induced rats[13] & also in deoxycortisone acetate (DOCA)-salt-hypertensive rats.[14]

Anticancer activity - Prostate cancer[15]

Proanthocyanidin (structure of epicatechin octamer) contained in grape stems is related to the anticancer activity.


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Anti prostate cancer activity was proven by the presence of cell growth inhibition from prostate cancer cells. Another proanthocyanidin anticancer mechanism is to increase apoptotic activity in prostate cancer cells and suppress the expression of prostate cancer-promoting gene fatty acid-binding protein five at mRNA and protein levels.

Anti-aging activity

Aging on the skin may be caused by radiation and pollutants. Based on Cronin's research, those grape seeds extract from V. vinifera L. containing t-resveratrol could slow the onset of aging and had the potential to be an ingredient for anti-aging products.[16]

However, Based on Sharif's research, seed extract of Vitis vinifera L. var. Muscat Hamburg could be an ingredient for an anti-aging product because it is rich in antioxidants and works by increasing skin elasticity.[17]

Antifungal activity[18]

Grape (V. vinifera L.) seeds extract had antifungal activity against Candida albicans, Malassezia furfur, and Trichophyton mentagrophytes. Compound that act as anti-fungal was flavan-3-ols. The higher extract concentration gave greater inhibition zone diameter formed against C. albicans.

The contents of grape (V. vinifera L.) canes were 3,4'-dimethoxy-resveratrol and 3,5-dimethoxy-resveratrol. Both compounds showed antifungal activity with a minimum inhibitory concentration of 29-37 µg/ml against Candida sp.

Discussion and Conclusion

Sarva Madahar Leha Yoga is the herbo-mineral preparation which is mentioned under the context of Madatyaya Chikitsa in Abhinav Chintamani First Part. Ingredients of Sarva Madahar Leha Yoga is (Kapitha, Dadima and Drakshya) Hepatoprotective activity, Antifungal activity, Antihypertension activity and Immunomodulatory Activity.

All ingredients of this formulation is Shit Virya, Madhur Vipak and Tridoshahar. Which mitigates all the three Doshas of Madatyaya. So, Ayurveda formulation Sarva Madahar Leha Yoga can helpful all types of Madatyaya (Alcoholism).

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