This interaction causes Dosha-Dushya Sammurchana (Dosha-bodily tissue interaction), which brings about obstruction of bodily channels (Srotodushti) and subsequently leads to expression of disorders internally (Antah) as well as externally (Bahir) such as Sheetapitta, Udarada, Kotha, and Utkotha (forms of inflammatory skin and allergic diseases).
न चात्र दोषाः प्रकुप्यन्तिन चाग्निर्दुष्यते पृथक्। न च दुष्याः प्रकुप्यन्तिन च व्याधिः प्रवर्तते॥ सन्निपातो यदा सर्वंतदा व्याधिः प्रवर्तते॥ (Madhava Nidana, 1.4-5)
This verse emphasizes the need for collective derangement of doshas, agni, and dhatus for disease manifestation. On the molecular level, the chronic ingestion of Viruddhahara causes subclinical inflammation through the modification of the eicosanoid cascade, which results in enhanced production of pro-inflammatory mediators like prostaglandin-2 and thromboxane A2 from arachidonic acid.
This biochemical sequence replicates the Ayurvedic process of Ama production, a pathogenic waste product that gets dispersed in the body, impedes Srotas (transmission channels), and localizes in tissues with Khavaigunya (structural or functional weakness), eventually culminating in disease.
स्रोतसां च प्रवृत्तीनां प्रधाना मलरोधतः। मलसङ्गः स दोषाणां कुर्वीत प्रतिघातनम्। (Charaka Samhita, Chikitsasthana 15.44)
The heating of oils or some foods is Viruddha and creates Ama, resulting in toxicity and disease, according to Ashtanga Hridaya. Therefore, the pathology is now spread from gut-based dysfunctions to systemic manifestations with the involvement of various Dhatus and Srotas.
The clinical effects of Viruddhahara are divided into Aashukari (acute) and Chirakari (chronic) manifestations. Acute effects are allergic responses, indigestion, or rashes on the skin, while chronic consumption develops metabolic syndromes like obesity, diabetes, cardiovascular conditions, and autoimmune diseases based on individual Prakriti (constitution), Agni strength, and intensity of incompatibility.
Diseases due to Viruddhahara
Chronic consumption of Viruddhahara (incompatible food) leads to a myriad of pathological conditions in many systems of the body.
According to Acharya Charaka, such food combinations that are not compatible are responsible for causing a disturbance in the normal process of Agni (digestive fire), causing Ama formation (metabolic toxins), and vitiating Doshas, ultimately causing Dhatu Dushti (tissue-level pathology). The long-term consequence can cause severe systemic disorders, even Mrityu (death), as said:
षाण्ढ्यान्ध्यवीसर्पदकोदराणां विस्फोटकोन्मादभगन्दराणाम् मूर्च्छामदाध्मानगलग्रहणां पाण्ड्वामयस्यामविषस्य चैव॥ (Charaka Samhita, Sutrasthana 26,102)
किलासकुष्ठग्रहणीगदानां शोथाम्लपित्तज्वरपीनसानाम्। सन्तानदोषस्य तथैव मृत्योर्विरुद्धमन्नं प्रवदन्तिहेतुम्। (Charaka Samhita, Sutrasthana 26,103)
Charaka has listed several disorders that occur due to such incompatible dietary habits, such as: Shandhya (impotency), Andhya (blindness), Visarpa (erysipelas), Jalodara (ascites), Visphota (boils), Unmada (mental disorder), Bhagandara (fistula in ano), Murcha (syncope), Mada (drunkenness), Aadhmana (abdominal distension), Galagraha (obstruction of the throat), Pandu (anemia), Ama, Kilasa (leucoderma), Kushta (various skin diseases), Grahani (malabsorption syndrome), Shotha (swelling), Amlapitta (gastritis), Jwara (fever), Pinasa (rhinitis), Santana Dosha (barrenness), and finally, Mrityu (death).
These conditions demonstrate the varied system-wide action of Viruddhahara on:
Reproductive system: Shukra Dhatu Dushti, causing impotence and infertility.
Digestive system: Grahani, Amlapitta, and Ama formation, causing malabsorption and metabolic syndromes.
Nervous system: Unmada, Murcha, and Mada.
Circulatory and immune systems: Pandu (anemia), Shotha (inflammation), and Kushta (chronic skin diseases).
Contemporary equivalents of these diseases are inflammatory bowel disease, skin allergies, autoimmune diseases, metabolic syndrome, infertility, neurological imbalances, and even endocrine-related hormonal dysfunctions. Experimental evidence is present to indicate that long-term consumption of such incompatible foods can lead to inflammation at the molecular level,