E-ISSN:2456-3110

Research Article

Management of Obesity

Journal of Ayurveda and Integrated Medical Sciences

2024 Volume 9 Number 6 JUNE
Publisherwww.maharshicharaka.in

Clinical Evaluation of Obenyl Tablet in the management of Obesity

Dnyaneshwar M1*, Lata K2
DOI:10.21760/jaims.9.6.1

1* Mote Dnyaneshwar, Principal Investigator, Vidnyanam Clinic, Pune, Maharashtra, India.

2 Kide Lata, Co-Investigator, Vidnyanam Clinic, Pune, Maharashtra, India.

Obesity, defined as abnormal or excessive fat accumulation, which may impair health, is measured by body mass index (BMI) ≥ 30 kg/m2. In the Asian population, the BMI cut-off of obesity is lower (≥27.5 kg/m2).[1] Prevalence rate of Obesity across the globe is alarmingly increasing, irrespective of geographical areas, race, sex and age. Obesity is associated with increased risk of morbidities such as systematic inflammation, insulin resistance, and lipid abnormalities, leading to various non-communicable diseases, including cerebrovascular and cardiovascular diseases and cancer.[2] To overcome such major concern and address this issue with safer and herbal solution Charak Pharma Pvt. Ltd’s, Obenyl Tablet was taken for this Clinical Evaluation study. The study was done on 113 patients with BMI in between 28 to 40. The study is open labelled controlled single arm study. Participants were given Obenyl tablet and allowed to consume regular diet. The study shows Excellent - 20.51% (15 patients), Good - 38.93% (30 patients), Fair - 28.31% (22 patients), Failure - 12.82% (10 patients). Study shows Mean Weight Loss of 3.33Kg at the end of the study. The present study showed the therapeutic results on Completion of 120th Day in comparison to 0 Day, as Obenyl Tablet has showed 87.18% good results.

Keywords: Obesity, Sthaulya, Over weight, accumulation of fat, Obenyl Tablet, Ayurveda

Corresponding Author How to Cite this Article To Browse
Mote Dnyaneshwar, Principal Investigator, , Vidnyanam Clinic, Pune, Maharashtra, India.
Email: 		Dnyaneshwar M, Lata K, Clinical Evaluation of Obenyl Tablet in the management of Obesity. J Ayu Int Med Sci. 2024;9(6):1-5.
Available From
https://jaims.in/jaims/article/view/3474

Manuscript Received Review Round 1 Review Round 2 Review Round 3 Accepted
2024-04-03 2024-04-15 2024-04-29 2024-09-03 2024-05-13
Conflict of Interest Funding Ethical Approval Plagiarism X-checker Note
Authors state no conflict of interest. Non Funded. The conducted research is not related to either human or animals use. 12.87 All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

© 2024by Dnyaneshwar M, Lata Kand Published by Maharshi Charaka Ayurveda Organization. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License https://creativecommons.org/licenses/by/4.0/ unported [CC BY 4.0].

J Ayu Int Med Sci 2024;9(6)1
Dnyaneshwar Mote et al. Clinical Evaluation of Obenyl Tablet in the management of Obesity

Introduction

The importance of obesity requires constant emphasis, not only because of excess mortality it carries, but also because of numerous complications & the predisposition it creates to the common & potentially serious conditions such as diabetes mellitus, cardiac disorders etc.[3]

It reduces the efficiency of those affected, it detracts from their ability to participate in many normal activities & it is frequently associated with emotional & other psychological disturbances, all of which may interfere in major way with the wellbeing of an individual, a family or a community.[4]

Definition of obesity

Obesity can be defined as an abnormal accumulation of fat in the stores of adipose tissue throughout the body. Obesity represents an accumulation of energy in excess of requirements & that weigh reduction can be achieved only by reducing every intake, by increasing output or by a combination of the two.[5]

Causes of obesity

1. Genetic & environmental factors (dietetic habits & economic factors)
2. Appetite & feeding pattern (consumption of more calories than required)
3. Less physical activities.
4. Endocrinal factors - Cushing’s syndrome, Adrenocortical hyperfunction, Hypothyroidism.
5. Genetical factors - No above-mentioned factors could be held to be responsible for obesity.[6]

Complications of obesity

1. Flat feet & Osteoarthritis of knee joint, hip joint & lumber spine.
2. Abdominal & diaphragmatic hernias.
3. Varicose vein.
4. Skin infection around folds of skin & axilla.
5. Diabetes mellitus.
6. Cardio vascular disorders: Hypertension, coronary atherosclerosis & angina pectoris. Obesity which is not a disease entity in itself but which is cause of hundreds of diseases has become fairly common nowadays. It is also accompanied by risks of early death, hypertension, heart diseases, diabetes etc.[7] Ayurveda has prescribed three ways of managing obesity they are diets, deeds & drugs.

bearing this in mind it was decided to see effect of herbal Obenyl tablet, in cases of obesity, free from other major illness like Diabetes, Heart diseases etc.

Materials and Methods

Total number of 113 patients were selected for the study, out of which 78 patients could complete the study & 35 cases were dropped out. The patients between age group 18-60 yrs. were included in the present study. The patients of both sexes were included in the study. The duration of the study was for 16 weeks.

Dosages of the Medicines

Test Drug was given as 2 tablet 3 times a day with luke warm water. Each tablet contains 500 mg of herbal ingredients.

Diet advice: Patients were kept on low calorie & fat free regular diet.

Criteria for selection of patients

Obese people have high risk of mortality or suffering serious illness. Most data, which relate the level of fatness to total mortality shows that the risk of mortality starts to increase, appreciably when BMI is above 40.[8] The definition of obesity in Asian population is BMI in between 28 to 40.[9]

Category: BMI (Body Mass Index)

Acceptable range  : 20-24

Overweight   : 25-29

Obesity   : 30-40

Extreme obesity  : More than 40

Body mass index (BMI) : kg(weight)/m2(height)[10]

Patients with BMI in between 28 to 40 were selected for the present clinical study. The obese patients with diabetes mellitus were included in present study. Patients with known history of and suffering from Cardiac Disorders, Hypertension and Endocrinal disorders like Cushing’s syndrome, adreno-cortical hyper function & hypothyroidism were excluded from the study. All patients were called for monthly follow up for 4 months. Each patient’s Anthropometric Data like body weight, BMI, Waist Circumference, Hip Circumference, Mid-Thigh Circumference and Mid Arm Circumference were recorded Day 0, 30, 60, 90 and 120.


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Dnyaneshwar Mote et al. Clinical Evaluation of Obenyl Tablet in the management of Obesity

Table 1: Sex wise distribution of patients

SexNo. of patientsPercentage
Male3342.30%
Female4557.69 %

Note: - It can be noted that Obesity sex-wise is more common among females.
jaims_3474_01.jpg

Table 2: Age wise distribution of patients

Age GroupNo. of patientsPercentage
18-2033.85%
21-3078.97%
31-401620.51%
41-502734.62%
51-602532.05%

jaims_3474_02.jpg
Table 3: Occupation wise distribution of patients

OccupationNo. of patientsPercentage
Hard working1012.82%
Businessman1215.38%
House-wife3139.74%
Student33.85%
Clerk1316.66%
Retired911.53%

jaims_3474_03.jpg

Statistical Analysis

Data is presented and expressed as Mean ± Standard Deviation, Percentile range. The Baseline Values Were Compared with Follow up Values using ANOVA. <0.05 P value was considered criteria for Level significance.

Observation

Table 4: Patients with Test medicine showed following overall response.

SNResponse to TreatmentNo. of Patients% of Patients
1.Excellent1520.51
2.Good3038.21
3.Fair2228.21
4.Failure1012.82
5.Adverse Effect00

As per data collected at the end of study as 87.18% of patients with Obenyl Tablet showed good results.

While 12.82 % of patients showed 15.38% minimum or no results.

No patient had any untoward effects.

Table 5: Effect of Obenyl Tablet on Anthropometric Variables

Anthropometric variablesDay 0Day 30Day 60Day 90Day 120
Weight (kg)75.45 ± 11.7075.57 ± 11.374.36 ± 11.2273.18 ± 11.2472.12 ± 11.19*
BMI (kg/m2)32.67 ± 1.5032.58 ± 1.5128.50 ± 1.4828.43 ± 1.4928.40 ± 1.44
Waist circumference (cm)98.97 ± 8.9998.42 ± 8.5896.67 ± 8.0796.10 ± 9.7795.01 ± 8.83*
Hip circumference (cm)104.99 ± 8.62104.92 ± 9.13103.31 ± 8.14103.02 ± 8.37*102.37 ± 8.03**
WHR0.94 ± 0.080.93 ± 0.070.93 ± 0.070.93 ± 0.070.92 ± 0.08
Neck circumference (cm)37.7 ± 5.1636.91 ± 4.8236.35 ± 4.7036.17 ± 4.24**35.89 ± 4.16***
Mid upper arm circumference (cm)31.94 ± 2.8431.67 ± 3.1531.17 ± 2.7931.5 ± 3.031.25 ± 2.73
Mid-thigh circumference (cm)54 ± 6.2653.89 ± 5.6952.03 ± 8.1951.78 ± 5.3751.35 ± 4.92
*p < 0.05, **p < 0.01, ***p < 0.001 as compared to day 0.

The average age of the recruited participants was 38.7 ± 9.42 years. There was clinically significant difference observed pre and post treatment in case of weight loss. The mean weight loss showed was 3.3 kg.


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Dnyaneshwar Mote et al. Clinical Evaluation of Obenyl Tablet in the management of Obesity

Presentation in Figure of Observation and Test Results
jaims_3474_04.jpg

The circumferential measures (waist, hip and neck) showed gradual reduction throughout the study period, which was statistically significant on day 90 (HC and NC) and day 120 (all three). The significant decrease in waist and hip did not reflect in corresponding decrease in waist-to-hip ratio. The other circumferential measures (MUAC and MTC) although showed reduction, but did not reach to statistical significance.

Discussion

Lipogenesis occurs in the liver and adipose tissue where carbohydrate and protein consumed in the diet can be converted to fat. The carbohydrates can be stored as glycogen in the liver and muscle and can be converted to triglycerides in the liver and transferred to adipose tissue for storage.[11]

The aim of Current study was to evaluate the efficacy of Obenyl Tablet in Obese Patients and to determine whether the Herbs will act as Fat Burners or Not. We observed significance Change in Waist, Hip and Neck Circumference, It proves that Obenyl has helped in releasing Fats from Peripheral Adipocytes and further oxidation of fat (Fat Burning). The physiological process of fat burning occurs when fats are liberated from adipocytes into circulation to supply the needed energy.[12]

Fat Burner termed is used for Herbal Supplements that claimed to acutely increase fat metabolism, impair fat absorption, increase weight loss, and increase fat oxidation during exercise.[13] A good fat burner must burn stored fats, break down and mobilize fat cells, increase metabolic rate, and inhibit the enlargement of fat cells.[14] Fat-burning supplements include conjugated linoleic acid.[15]

Which is found in Amla, hirada, the ingredients from Obenyl tablet. herbal ingredients has the Fat burners ability.[16] there are foods & Herbs that have the ability to burn fat as they are ingested.[17] As the Obenyl showed Significant Mean Weight Loss of 3.33kg, the Herbs in Obenyl Must have been acting like Fat Burners.

Fat burner is not meant to replace a good diet and exercise plan. The best way to help the body stimulate /metabolism and activate the fat burning abilities is to eat thermogenic foods, drink plenty of water, exercise regularly.[18] Along with Herbal Medications such as Obenyl Tablet.

Conclusion

The study was carried out in 78 patient suffering from obesity. The obese patient with endocrine disorders e.g. Cushing’s syndrome, Hypothyroidism were excluded from the study. The Obese patients with diabetes mellitus were included in study. The patients with Obenyl Tablet showed 87.18% good results. The Study shows significant reduction in Waist, Hip and Neck Circumference and mean weight loss showed was 3.3 kgs. No adverse effects and weight gain were observed in the course duration. Hence, it can be concluded that Obenyl Tablet is effective treatment in obesity with no side effects.

References

1. Rajat Das Gupta 1, Nowrin Tamanna et al. Obesity and Abdominal Obesity in Indian Population. Epidemiologia 2023, 4, 163–172.

2. Kamel Ajlouni1 et al, An alarmingly high and increasing prevalence of obesity in Jordan, Epidemiol Health 2020;42,

3. Global Health Complications of Obesity, 2020

4. Abdulmoein E. Al-Agha et al : Correlation between obesity and emotional, social, and behavioral problems associated with physical limitation among children and adolescents in Western Saudi Arabia

5. Kiran K. Panuganti et al. Obesity - StatPearls - NCBI Bookshelf

6. https://www.nhs.uk/conditions/obesity/diagnosis,


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7.http://ecoursesonline.iasri.res.in/mod/page/view.php?id=21871Normal and Therapeutic Nutrition 3(2+1) Lesson 31: Overweight and Obesity – causes, symptomsanddietary management

8. Dr Katherine M. Flegal, et al. Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index Categories, JAMA. 2013 Jan 2; 309(1): 71–82.

9. GODA A et al, Obesity and Overweight in Asian People, Circulation Journal Vol.80, December 2016,

10. https://www.nhs.uk/conditions/obesity/

11. A Kersten, Sander. Mechanisms of nutritional and hormonal regulation of lipogenesis. 2001. EMBO reports, 2:4:282-286. https://doi.org/10.1093/embo-reports/kve071

12. Porter SA, Massaro JM, Hoffmann U, Fox CS (2009) Abdominal subcutaneous adipose tissue: a protective fat depot? Diab Care 32(6):1068–1075

13. Podder K, Kolge S, Benzman L, Mullin G, Cheskin L (2011) Nutraceutical supplements for weight loss: a systemic Review. Nutr Clin Pract 26(50):539–552

14. Nawrot P, Jordan S, Leonard S (2013) Effects of caffeine on human health. Food Addit Contam 20(1):1–30

15. Eric E, Berg DC (2010) The 7 principles of fat burning, 1st edn. Blackwell Science, Oxford

16. Nawrot P, Jordan S, Leonard S (2013) Effects of caffeine on human health. Food Addit Contam 20(1):1–30

17. Paul CB (2009) Nutrients that speed fat loss and why you should get them in your diet, 18th edn. McGraw-Hill, Boston

18. Paul CB (2009) Nutrients that speed fat loss and why you should get them in your diet, 18th edn. McGraw-Hill, Boston


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