Jamun: An Alchemy Botanical

Payaam Vohra; Kundan Redekar; Sakshi Pawar; Vaishali Patil

doi:10.21760/jaims.9.10.38

E-ISSN:2456-3110

Review Article

Jamun

Journal of Ayurveda and Integrated Medical Sciences

2024 Volume 9 Number 10 OCTOBER

Publisher

www.maharshicharaka.in

Jamun: An Alchemy Botanical

Vohra P^1*, Redekar K², Pawar S³, Patil V⁴

DOI:10.21760/jaims.9.10.38

^1* Payaam Vohra, B Pharma Scholar, HK College of Pharmacy, Mumbai, Maharashtra, India.

² Kundan Redekar, B Pharma Scholar, VIVA Institute of Pharmacy, Mumbai, Maharashtra, India.

³ Sakshi Pawar, B Pharma Scholar, VIVA Institute of Pharmacy, Mumbai, Maharashtra, India.

⁴ Vaishali Patil, B Pharma Scholar, VIVA Institute of Pharmacy, Mumbai, Maharashtra, India.

Plants have provided mankind with herbal cosmetics for many centuries and their utilization has been continuously increasing over the time. Syzygium cumini belonging to the family Myrtaceae commonly known as Eugenia jambolana is rich in phytochemicals. Jamun or Black Plum, is indigenous to the Indian subcontinent including countries such as Sri Lanka, Nepal, Pakistan. The tree flourishes in tropical and subtropical climates, often growing in forests, riverbanks and open fields. The investigations on the cosmetic values of jamun that have been conducted recently are the main topic of this review. These formulations of Jamun are characterized by incorporation of beneficial properties such as anti-aging, antioxidants, anti-inflammatory agents, and also reduce photoaging. Key phytoconstituents include tannins, flavonoids, terpenoids, saponins, phenolic acid and Essential oils. Syzygium cumini exhibits both Pharmacological and Ayurvedic benefits, providing a valuable component in cosmetic formulations. According to literature review and various research studies Syzygium cumini (leaf) and (seed) oils showed anticollagenase, anti-elastase and anti-hyaluronidase activities. Thus S. cumini oils should be considered for cosmetic preparations for the manifestation of healthy skin. Jamun can bring a paradigm shift in the cosmetic as well as cosmeceutical industry.

Keywords: Jamun, Syzygium cumini, Eugenia jambolana

Corresponding Author	How to Cite this Article	To Browse
Payaam Vohra, B Pharma Scholar, , HK College of Pharmacy, Mumbai, Maharashtra, India. Email:	Vohra P, Redekar K, Pawar S, Patil V, Jamun: An Alchemy Botanical. J Ayu Int Med Sci. 2024;9(10):227-238. Available From https://jaims.in/jaims/article/view/3759

Manuscript Received	Review Round 1	Review Round 2	Review Round 3	Accepted
2024-09-13	2024-09-24	2024-10-04	2024-10-14	2024-10-24
Conflict of Interest	Funding	Ethical Approval	Plagiarism X-checker	Note
None	Nil	Yes	12.36

© 2024by Vohra P, Redekar K, Pawar S, Patil Vand Published by Maharshi Charaka Ayurveda Organization. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License https://creativecommons.org/licenses/by/4.0/ unported [CC BY 4.0].

J Ayu Int Med Sci 2024;9(10)227

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Payaam V et al. Jamun: An Alchemy Botanical

Introduction

In traditional Ayurvedic system, Jamun is mentioned as Fruit of Gods and has been documented in ancient texts over 4000 years. Syzygium cumini has a long history and cultural significance in Indian subcontinent. The species has dispersed over south Asia and other tropical regions, where it’s been integrated into various agro-ecosystems. Its historical significance is evidenced by archaeological and botanical records indicating its longstanding role in both cultural and medicinal contexts. Jamun has been valued for its ability to improve skin health and protect skin from oxidative stress.^[1] The fruits are ellipsoid or oblong, Black with pinkish mesocarp with single seed have a total weight of 25% and 75% pulp.^[2,4] Botanical Name of Jamun is Syzygium cumini (L.).^[3]

The Taxonomical classification of Syzygium cumini is as follows.^[5,6

Kingdom	Plantae
Subkingdom	Viridiplantae-Vascular plants
Infrakingdom	Streptophyta
Superdivision	Embryophyta
Division	Tracheophyta
Subdivision	Spermatophytina - Seed plant
Class	Mangoliopsida - Dicotyledons
Superorder	Rosanae
Order	Myrtales
Family	Myrtaceae -Myrtle
Family Genus	Syzygium
Species	cumini (L.)Skeels

Microscopy

1. Seed: Wavy outer layer epidermis, 1 to 3 layers of sub epidermis, a discontinuous ring of group of stone cells, tangentially elongated obliterated parenchyma cells with vascular strands.^[7]

2. Stem: Mature bark, the cork layer exhibits a broad zone of differentiated cork, which is divided into upper and lower cork zone, collectively forming Rhytidome, the cork comprises tangentially elongated rectangular cells.^[3]

3. The upper layer consists of thick cells, stratified and reddish brown in color; this layer contains a group of 2-4 stone cells and crushed phloem. The lower cork zone is thin and colorless. The secondary phloem contains sieve elements and phloem rays.

The phloem parenchyma is thin-walled and polyhedral. The stone cells are oval to angular and elongated, while fibers are aseptate.^[8,10]

4. Leaf

Shape: Oblong-oval.
Dimensions: 5 to 18 cm long and 2.5 to 8 cm wide.
Apex: blunt or tapering to a point.
Odour: Turpentine like.
Taste: Slightly astringent^[9]

5. Powder microscopy: The powder microscopic characters of testa and seed kernel are reviewed and reported in Fig 1.^[10,11]

Figure 1: Characteristic features of Jamun

Adulteration in Jamun Seed Powder

Table 1: Microscopic features of Syzgium cumini^[12]

SN	Microscopic Characters	Testa	Seed Kernel
1.	Fibers	Numerous, lignified, thick walled striated with blunt end.	Absent
2.	Crystals	Absent	Calcium oxalate crystals ranging from 15-18 μm
3.	Starch Grain	Absent	Simple and abundant starch grains, round to oval, faint transverse striations, 5-45 μm in diameter.
4.	Vascular elements	Present	Present
5.	Brownish elements	Present	Present
6.	Scleroids	Elongated and mostly narrow lumen, larger in size irregular in shape and spindle shape	Absent

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Starch or fillers: Cheaper fillers like starch are sometimes added to Jamun seed powder to increase volume. Syzygium aqueum: (Water Apple): Sometimes mixed with Jamun due to its resemblance.

Geographical Distribution

There are over 1100 species in the genus Syzygium which is native to Madagascar, Africa and the Southern east Asia pacific region. The most diverse areas range from Malaysia to North- eastern Australia. 12 species reported from western ghats.^[12-15]

Table 2: Describes the geographical spread of Syzygium cumini.

Syzygium alternifolium (Wight) Walp.Syzygium aqueum (Burm.f.) AlstonSyzygium aromaticum (Linn.) Merrill & Perry.Syzygium bracteatum (Willd.) RaizadaSyzygium malaccense (Linn.) Merrill & Perry.Syzygium samarangense (Blume.) MerrillSyzygium jambos (Linn.) Alston.Syzygium mapрасеитSyzygium arnottianumSyzygium claviflorum

Syzygium fruticosum (Roxb.) D.C.Syzygium paniculatum Gaertn.Syzygium javanica Lam.Syzygium densiflorum Wall ex. WightSyzygium uniflora Linn.Syzygium zeylanicum (Linn.) DC.Syzygium guineenseSyzygium travancoricumSyzygium bourdilloniiSyzygium oblatum (Roxb)

Figure 2: Pie Chart for Geographical availability of Jamun^[16]

Cultivation and Collection

The genus Syzygium comprises about 1100 species in world wide and 12 species in western ghats. There is no need for agriculture to grow the plant. The tree flourishes in Tropical and Subtropical climates, often growing in forests, riverbanks and openfield.

It grows upto 30 m in height in spring (February – March) and Monsoon (July- August). The immature fruit is in Green in color and changes to Black crimson. The plant starts to flower and fruits are produced, yield about 2kg after four years. The young trees require continuous irrigation (at least 8 to 10 irrigation) per year, but after the trees get established, the irrigation can be reduced. These formulations are characterized by incorporation of beneficial properties such as antiaging, antioxidants, anti-inflammatory agents, and also reduce photoaging. Key constituents include Tannins, Flavonoids, Terpenoids, Saponins, Phenolic acid and Essential oils. As per research Syzygium cumini (leaf) and (seed) oils showed superior anti-collagenase, anti-elastase and anti-hyaluronidase activities.^[17,18] The process of cultivation and collection is briefly described in Fig.3.

Figure 3: Cultivation and Collection of Syzygium Cumini^[19,20]

Phytoconstituents

Pytochemicals are bioactive compounds found in plants which are nonnutritive but exhibit biological activities that can contribute to the prevention of diseases.^[15,21] Jamun is a warehouse for phytochemicals useful for cosmetic purpose as depicted in Fig 4.

Phenolic compounds

Phenolic are the hydroxyl group which contains hydroxyl group (-OH) bonded directly to aromatic hydrocarbon group. The important groups of phenolic compounds are flavonoids, phenolic acid and polyphenols.

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These are the plant secondary metabolites and have a defense role. It acts as antioxidants, antibacterial, and anti-inflammatory agents. Thus these compounds are used for many skin problems such as aging, healing, acne, eczema, etc.^[22]

Flavonoids

Flavonoids including quercetin, myricetin, and isoquercetin identified in different parts of S. cumini. Flavonoids are renamed for its anti-inflammatory, anticancer and other beneficial effects.

Alkaloids

Alkaloids, including Jambosine and Jamboline isolated from the seeds of Jamun. These alkaloids are believed to play a role in the plant's lipid metabolism.

Vitamins

Jamun is a good source of vitamins such as Vitamin A, Vitamin B complexes (B1, B2, B5, B6, etc) these give plants antioxidants and nutritional benefits.

Terpenoids

Terpenoids are the five carbon isoprene units, Terpenes are found in plants as an essential oil containing Antibacterial and Free Radical Scavenging properties. Ursolic acid, widely diffused in plants and used in cosmetic preparation.^[22]

Figure 4: Phytochemicals of Jamun useful as cosmetics^[23]

Table 3: Part wise utilization of Jamun in cosmetics^[21,23,24]

Part	Metabolic Class	Identified Compounds	Uses on Skin
Fruit	Flavonoid	Myricetin Myrecetin deoxyhexoside	Anti-Aging, Anti-inflammatory
	Tannins	HHDP-galloyiglucose, Trigalloylglucose	Photoprotection, Astringent
	Terpenes	Citronellol, Geraniol, Hotrineol, phenylpropanal	Anti-inflammatory, Antioxidant
	Anthocyanins	Malvidin, Petunidin, cyanidin	Anti-Aging, Antioxidant, Anti-inflammatory
	Phenolic acids	Ellagic acid, Gallic acid	Skin brightening, Anti-Aging
Leaves	Flavonoids	Kaempferol, Catechin, Myricetin	Depigmentation agent
	Tanning	Nilocitin, HHDP-glucose, Pentagalloyglucose	Antipruritic/Anti-Rash agent
	Terpenes	a-pinene, a-cadinol, pinocarvone, myrtenol,Eucarvone, Cineole	Moisturizing agent, Anti-inflammatory, Anti-acne
	Phenolic acids	Ferulic acid, Caffeio acid, Chlorogenic acid, Ellagic acid, Gallic acid	Skin restoration, Wound healing, Anti-inflammatory, Antioxidant
Roots	Flavonoid glycosides	Isorhamnetin, 3-O-rutinoside	Anti-Aging, Antioxidant, Moisturizer
Seeds	Flavonoids	Quercetin 3,5,7,4-tetrahydroxy flavanone, Rutin	Photoprotective, Antioxidant, Antiinflammatory
	Tannins	3-galloyIglucose Corilagin, 3.6- HHDP- glucose	Antioxidant, Cleansing agent Emulsifying agent
	Terpenes	A-Terpene Betulinic acid, Eugenol Bpinene, B-Terpinene	Skin soothing, Prevent skin irritation and redness
	Phenolic acids	Feulic acid, Gallic acid, Ellagic acid, Caffeic acid	Antioxidant, Anti-inflammatory
Flower	Flavonoids	Isoquercetin, Quercetin, Kaempferol	Photoprotective, Antioxidant
	Terpenes	Oleanolic acid, Eugenol	Photoprotective, Reduce dark spots, Antimicrobial
	Phenolic acids	Ellagic acid	Antioxidant
Stem Bark	Flavonoids	Kaempferol, Myricetin, Quercetin	Depigmentation, Wound healing
	Terpenes	Betulinic acid, B-Sitosterol Friedelin	Skin soothing, Antimicrobial
	Phenolic acids	Ellagic acid, Gallic acid 3.3-di-omethyl, ellagic acid	Antioxidant

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Figure 5: Mechanism of Jamun as a Cosmetic on skin^[25,26,29]

Jamun has various mechanisms for its utilization in Cosmetics majorly showing prominent actions like Anti-inflammatory, anti-aging, anti-oxidant, anti-microbial and skin brightening effects as specified in Fig 5.

Cosmetic Uses

1. Syzygium cumini fruits have antioxidant and free radical scavenging properties due to the high anthocyanin content.
2. Majority of antioxidant action may be attributed to molecules such as flavonoids, isoflavones, flavones, and anthocyanin rather than the previously recognized vitamins C, E, and B carotene.^[27]3. Flavonoids have antioxidant and anti-aging characteristics.They also protect the skin from UV radiation.^[28]4. Phenolic antioxidant action is owing to their redox potential, which allows them to operate as hydrogen donors, singlet oxygen quenchers, and metal chelators.^[29]5. Blue light is high-energy visible light emitted from phones or screens which cause wrinkles, acne pigmentation via free radical generation induces oxidative stress in live skin which leads to damage DNA, resulting in inflammation and collagen and elastin degradation. To prevent damage caused by blue light use natural antioxidants.^[30]6. Syzygium cumini extract has antioxidant properties that prevent the formation of reactive oxygen species by free Radicals.
7. Syzygium cumini leaf extract in methanol included high levels of phenolic, saponin, flavonoids, and tannin.

8. Syzygium cumini methanol extract and leaf essential oil might be considered effective sources of natural antioxidants.^[31]9. Syzygium cumini oil is used as an antibacterial and scent in cosmetics.
10. Jamun contains thiamine (vitamin B1) which is used as a fragrance ingredient and skin-conditioning agent.^[32,33]11. Vitamin C is beneficial to pale skin complexions. Syzygium cumini may help lighten skin pigmentation.
12. It helps to detoxify your blood while also keeping your skin clean and radiant.
13. It is high in iron and boosts hemoglobin levels in the body.
14. The astringency of the fruit is related to the presence of phenolic chemicals. Its astringent properties allow it to maintain greasy skin clean, smooth, and acne-free because of the presence of oxalic acid, gallic acid, malic acid, tannins, betulinic acid, and other compounds.^[34,35]15. Syzygium cumini's root, bark, flower, and leaves all contain terpenes, the majority of which are volatile compounds. Saponin and triterpene exhibit hydrophilic and lipophilic characteristics.^[36]

Adverse Effects

1. Contact dermatitis: Some individuals may develop and allergic reaction when contact with jamun or products containing jamun Symptoms include redness, itching, smelling and rashes at the site of contact.
2. Urticaria: In rare cases, exposure to jamun may cause hives, characterized by itchy, raised welts on the skin.

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3. Exacerbation of Pre-existing skin conditions: individuals with sensitive skin or conditions like eczema or rosacea may experience worsening symptoms.
4. Pigmentation Changes/ Hyperpigmentation: In correct or excessive use may lead to uneven skin tone or dark spots in sensitive individual
5. Staining: The deep purple color of Jamun can stain the skin temporarily, specially in products with high anthocyanin content.^[37-39]

Marketed Formulation:

Table 3: Marketed Preparations of Jamun in Cosmetics and Cosmeceutical Industry^[40,41,64]

Brand Name	Type of formulation	Dose	Price
PLIX	Moisturizer	50g	399
PLIX	Patch	100mg	549
MOTHER SPARSH	Face wash	100ml	149
JASHVII HERBAL	Serum	30ml	134
ILLUMINATE	Sunscreen	30g	299
PLIX	Toner	150ml	199

Table 4: List of Cosmetic Products involving Jamun (Syzygium cumini)

Product	Primary Benefits	Key Ingredients	Target Audience	References
Face Cream	Anti-aging, Hydration, Nourishment	Jamun extract, Hyaluronic acid, Vitamin E	All skin types	[42]
Face Mask	Cleansing, Brightening, Rejuvenation	Jamun extract, Kaolin clay, Aloe Vera	Oily to Combination skin	[43]
Lip Balm	Hydration, Protection, Natural tint	Jamun extract, Shea butter, Beeswax	All skin types	[44]
Shampoo	Strengthening, Dandruff control, Scalp health	Jamun extract, Tea tree oil, Vitamin E	All hair types	[45]
Body Lotion	Moisturization, Nourishment, Even skin tone	Jamun extract, Shea butter, Glycerin	Dry to Normal skin	[42,46]
Scrub	Exfoliation, Cell regeneration, Smoothing	Jamun extract, Sugar, Walnut shell powder	All skin types	[41,47]
Face Serum	Darkspot reduction, Brightness, Elasticity	Jamun extract, Niacinamide, Vitamin C	All skin types	[48]
Hair Oil	Nourishment, Hair growth, Shine	Jamun extract, Coconut oil, Argan oil	All hair types	[45,66]
Under-Eye Cream	Dark circle reduction, Puffiness control, Hydration	Jamun extract, Caffeine, Hyaluronic acid	All skin types	[47]
Toner	pH balancing, Pore tightening, Refreshing	Jamun extract, Witch hazel, Rose water	Oily to Combination skin	[48]

Figure 6: Cosmetic formulations of Jamun

Jamun has been incorporated in various formulations like Face creams, Lotions, Shampoo, Lip balms, Hair oils etc. Fig 6 clearly showcases various cosmeceutical formulations of Jamun.

Home Made Remedies

1. Jamun Facial Pack - Mash a few ripe Jamuns and add a tablespoon of yogurt. - After applying the mixture on your face, leave it on for fifteen - twenty minutes, and then rinse it off. - Rinse in lukewarm water. This can help reduce pigmentation and make your skin sparkle.^[49]2. Jamun Juice Toner. - Extract the juice from fresh Jamuns. - Add a few drops of lemon juice. - Apply the mixture to your face with a cotton pad. It can help constrict pores and provide a pleasant sensation.^[50]3. Jamun and Honey Mask. - Mash a few Jamuns and add a spoonful of honey. - After applying the mixture on your face, leave it on for fifteen minutes, and then rinse it off. - Rinse with warm water. This mask can hydrate and improve the texture of the skin.^[51]4. Jamun with aloe vera gel. - Combine Jamun pulp with aloe vera gel. -After applying the mixture on your face, leave it on for fifteen minutes, and then rinse it off. This combination can soothe and moisturize the skin. -Always perform a patch test before using any new medication to ensure you do not experience any allergic reactions.^[52]

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5. Jamun - Combine mashed Jamun pulp and a tablespoon of crushed oats. - Gently apply this mixture on your face in circular strokes. - Rinse with lukewarm water. This scrub exfoliates dead skin cells and brightens your appearance.
6. Jamun with Turmeric Paste - Mix mashed Jamun with a pinch of turmeric powder to make a paste. -After applying the mixture on your face, leave it on for ten - fifteen minutes, and then rinse it off. - Turmeric contains anti-inflammatory effects that can enhance the advantages of Jamun.^[53]7. Jamun and Green Tea Toner - Make a cup of green tea and allow it to cool. - Mix in a few teaspoons of Jamun - Use a cotton pad to tone and freshen your skin.^[54]8. Jamun with Almond Oil - Combine Jamun pulp and a teaspoon of almond oil. - Apply to your face and leave it on for 20 minutes before rinsing it off. - Almond oil may provide additional moisturizing advantages.
9. Jamun and Cucumber Extract. - Combine Jamun pulp and cucumber juice. - Apply to the skin and let it sit for 15 minutes before rinsing. - This combination might aid to soothe and hydrate the skin.
10. Jamun & Milk Mas - Combine ripe Jamun and a tablespoon of milk. - After applying the mixture on your face, leave it on for fifteen - twenty minutes, and then rinse it off. Rinse in lukewarm water. Milk nourishes and hydrates the skin, while Jamun contains antioxidants.^[55]11. Jamun and Sandalwood Powder - Combine mashed Jamun and a teaspoon of sandalwood powder. - Apply it to your face and leave it on for 15-20 minutes. - Rinse with warm water. Sandalwood is noted for its calming and brightening effects.^[56]12. Jamun and Rose Water Toner - Combine Jamun juice and rose water in equal parts. - Apply to your face with a cotton pad. - This toner can assist to balance skin tone and refresh the complexion.^[57]13. Jamun and Avocado Paste. - Mash the Jamun and combine with a little amount of ripe avocados. -After applying the mixture on your face, leave it on for 15 minutes, then rinse it off. - Rinse well. Avocado provides hydrating and nourishing effects to the Jamun.^[58]
14. Jamun with Coconut Oil - Combine Jamun pulp and a teaspoon of coconut oil. -After applying the mixture on your face, leave it on for 20 minutes, and then rinse it off. -

Rinse with warm water. Coconut oil can assist to deeply hydrate skin and boost benefits of Jamun.
15. Jamun and Baking Soda Scrub - Mix Jamun pulp with a pinch of baking soda to make a paste. - Massage gently into your face, and then rinse with lukewarm water. - This can help exfoliate dead skin cells and brighten the complexion.^[59,60]16. Vitamin E Oil and Jamun - Combine a few drops of vitamin E oil with the mashed Jamun. - After applying the mixture on your face, leave it on for twenty minutes, then rinse it off Vitamin E can offer extra nutrition and aid in skin regeneration.

Table 5: Diseases associated with Jamun plant^[61]

Disease	Causal organism	Plant part affected	Control Measure
Diseases Leaf rot and fruit spot	Glomerella cingulata	Leaf and fruit	Dithane Z -78 (0.2%).
White fly	Dialeurijdes eugenia	Fruits	Maintain sanitation, Destroy maggots
Leaf eating caterpillar	Corea subtilis	Leaf	dimethoate 30 (0.06 %) or malathion (0.05%)
Jamun leaf roller	Polychorosis cellifera	Leaf	Dimethoate 30 (0.06%)
Leaf webber	Argyroploce aprobola Argyroploce mormopa	Leaf	Quinalphos (0.05%)
Fruit fly	Bactrocera spp	Fruit	Use traps, Destroy Infested fruits
Seed Borer	Anselmella kerrichi	Seed	Lambda Cyhalorthrin 0.6-1ml/l

Recent Advancements

Personalized cosmetics

Customized Serums: Formulate serums with concentrated Jamun extract tailored to target specific skin concerns such as hyperpigmentation, acne, or fine lines.
Personalized Creams: Create day and night creams that incorporate Jamun for different skin types (e.g., lighter formulations for oily skin, richer ones for dry skin).
Tailored Masks and Exfoliants: Develop face masks and exfoliants that provide deep cleansing and rejuvenation, customized for varying skin sensitivities.
Bespoke Lip Balms: Offer lip balms with personalized levels of hydration and tint, using Jamun's natural color and emollient properties.

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Customized Hair Care: Create shampoos and conditioners that address specific hair and scalp concerns, incorporating Jamun for its antimicrobial and antioxidant benefits.
Jamun-based personalized skincare kits: Containing a cleanser, toner, serum, and moisturizer customized to individual skin needs.
Jamun-infused luxury skincare: Targeting high-end consumers seeking natural and effective products.
Jamun-based supplements: For internal support of skin health.^[62-64]

Amalgamation of Network Pharmacology into exploration of Jamun as cosmeceutical

Compound Identification: Identify the bioactive compounds in Jamun. This includes flavonoids, anthocyanins, and other phytochemicals.
Target Prediction: Utilize computational tools and databases to predict potential target proteins for these compounds in the skin. These targets could include enzymes, receptors, and other proteins involved in skin functions.
Network Construction: Build a protein-protein interaction network to understand the relationships between the identified target proteins.
Pathway Analysis: Analyze the pathways involved in skin-related processes (e.g., inflammation, collagen synthesis, antioxidant defense) to identify potential points of intervention for Jamun
Mechanism Elucidation: Based on the network analysis, propose potential mechanisms of action for Jamun in addressing skin concerns.^[65-67]

Network Diagram

Jamun Bioactive Compounds
↓
Multiple Biological Targets
↓
Integrated Pathways (Antioxidant, Anti-inflammatory, etc.)
↓
Cosmetic Benefits (Anti-aging, Skin Brightening, Anti-acne, etc.)

Table 6: List of recent patents associated with Jamun

Patent Id	Title	References
EP3402462B1	A nanobiocomposite formulation for wound healing and a process thereof	[68]
US20200323745A1	Topical skin care formulations comprising plant extracts	[69]
US20070086972A1	Hair growth compositions and methods for treating hair loss	[70]
US9238153B2	Transoral methods and compositions for wrinkle reduction and cosmetic lip	[71]

Conclusion

In nutshell Jamun (Syzygium cumini) holds significant potential in the realm of cosmetics due to its rich phytochemical profile and antioxidant properties. The presence of anthocyanins, flavonoids, and phenolic compounds in Jamun contributes to its skin-enhancing abilities, including anti-aging, skin brightening, and anti-inflammatory effects. Incorporation of Jamun in various formulation can aid in alleviating wide range of skin related problems These properties make Jamun a promising natural ingredient for developing skincare formulations that promote skin health. Development of natural and sustainable products Utilization of Jamun into cosmetic formulations offers a novel approach to meet demand of herbal cosmetics while harnessing the benefits of this traditional fruit. Future research and development should focus on optimizing the extraction and stabilization of Jamun's active compounds to fully realize its potential in cosmetic applications. Thus we can conclude that Jamun has high scope in cosmeceutical industry to promote skin aesthetics as well as maintain well-being of dermatological system.

References

1. Hrikant Baslingappa Swami, Nayan Singh J. Thakor , Meghatai M. Patil , Parag M. Haldankar. Jamun (Syzygium cumini (L.)):A Review of Its Food and Medicinal Uses .Food and Nutrition Sciences. 2012;3:1100-1117
2. Katiyar D, Singh V, Ali M. Recent advances in pharmacological potential of Syzygium cumini: A review. Advances in Applied Science Research. 2016;7(3):1-2.

J Ayu Int Med Sci 2024;9(10)234

Payaam V et al. Jamun: An Alchemy Botanical

3. Jadhav VM, Kamble SS, Kadam VJ. Herbal medicine: Syzygium cumini: A review. Journal of Pharmacy Research. 2009 Aug;2(8):1212-9.
4. Porika H, Suchithra M. Jamun: An underutilized fruit loaded with nutraceuticals: A review. Journal of Pharmacognosy and Phytochemistry. 2022;11(4):326-30.
5. Agarwala P, Gaurb PK, Tyagia N, Purib D, Kumarc N, Kumard SS. An overview of phytochemical, therapeutic, pharmacological and traditional importance of Syzygium cumini. Asian J Pharmacogn. 2019;3(1):5-17.
6. Singh H, Sharma V, Sharma B, Kumar M, Rana N. Jamun (Syzygiumcumini ) Seeds: A Review on Phytochemistry, Pharmacology, Nutritional Profile and traditional uses. 2024 May;23(5):547.
7. Govindarajan N, Ravichandran L, Chelladurai PK, Pandey A, Murugesan V, Kusuma G. Pharmacopoeial Compliance of Marketed Formulations containing seeds of Syzygium cumini (L.) Skeels. Research Journal of Pharmacy and Technology. 2023;16(12):5823-7.
8. Pai RJ, Valder B, Palatty PL, Shivashankara AR, Baliga MS. Gastrointestinal Protective Effects of Eugenia jambolana Lam.(Black Plum) and Its Phytochemicals. Academic Press; 2012 Oct 22.
9. Do Carmo Brito BN, da Silva penar, santoslopesa, camposchistér.Anthocyanins of Jambolão (Syzygium cumini): Extraction and ph-Dependent Color Changes. J Food Sci. 2017Oct;82(10):2286-2290. Doi:1111/1750-3841.13847. Epub 2017 Aug 23.
10. Ross JA, Kasum CM Dietary flavonoids: bioavailability, metabolic effects, and safety. Annual Review Nutrition 2002; 22(1):19-34
11. Rhahman AU, Zaman K. Medicinal plants with hypoglycemic activity. J Ethnopharmacol 1989; 26:1-55.
12. Ayyanar M, Subash-Babu P. Syzygium cumini (L.) Skeels: A review of its phytochemical constituents and traditional uses. Asian Pacific journal of tropical biomedicine. 2012 Mar 1;2(3):240-6.
13. Katiyar D, Singh V, Ali M. Recent advances in pharmacological potential of Syzygium cumini: A review. Advances in Applied Science Research. 2016;7(3):1-2.
14. Kumar A. Central nervous system activity of Syzygium cumini Pakistan J. 2007;(6):698-700
15. Ramakrishna S, Khan S. A Comprehensive Review on Therapeutic Potential of Syzygium cumini. Journal of Pharma Insights and Research. 2024 Apr 16;2(2):159-68.

16. Gordon A, Jungfer E, da Silva BA, Maia JG, Marx F. Phenolic constituents and antioxidant capacity of four underutilized fruits from the Amazon region. Journal of agricultural and Food Chemistry. 2011 Jul 27;59(14):768899.
17. More RN, Hingmire PM, Jadhav DM. Primary phytochemical and pharmacognostic studies on Syzygium cumini L(Jambhul). Journal of Pharmacognosy and Phytochemistry. 2024;13(1):299-305.
18. Fossen T, Andersen ØM. Spectroscopic techniques applied to flavonoids. Flavonoids:chemistry, biochemistry and applications.15 feb2006; 37-142
19. Ramya S, Neethirajan K, Jayakumararaj R. Profile of bioactive compounds in Syzygium cumini-a review. J. Pharm. Res. 2012 Aug;5(8):4548-53.
20. Mahmoud II, Marzouk MS, Moharram FA, El-Gindi MR, Hassan AM. Acylated flavonol glycosides from Eugenia jambolana leaves. Phytochemistry. 2001 Dec 1;58(8):1239-44.
21. Choudhary A, Noman M, Bano U, Khan AA, Akhtar J, Mir SR, Yar MS. Medicinal and therapeutic properties of Jamun (Syzygium cumini)–A Comprehensive Review. International Journal of Pharma Professional’s Research (IJPPR). 2023;14(2):15-23.
22. Cho KS, Lim TR, Lee K. Terpenes from forest and human health. Toxico Res. 2017; 33:97-106.
23. Baliga MS, Bhat HP, Baliga BR, Wilson R, Palatty PL. Phytochemistry, traditional uses and pharmacology of Eugenia jambolana Lam.(black plum): a review. Food Research International. 2011 Aug 1;44(7):1776-89.
24. Meenakshi Kumawat, Jyoti Damor, Jaya Kachchhwaha, Ayush Kumar Garg and Chandan Singh Pharmacological properties and therapeutic potential of syzygium cumini (jamun): a review World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 2018Jan18;7(3), 312-322.
25. Vijayanand P, Rao LJM, Narasimham P. Volatile flavor components of Jamun fruit (Syzygium cumini) Flavour fragrancej. 2001;16:47–49.
26. Agarwala P, Gaurb PK, Tyagia N, Purib D, Kumarc N, Kumard SS. An overview of phytochemical, therapeutic, pharmacological and traditional importance of Syzygium cumini. Asian J Pharmacogn. 2019;3(1):5-17.
27. Rehaman S. Therapeutic traits of jamun tree: Syzygium cumini (Linn.) To combat against covid-19. Researchgate. Net. 2021;6:248-53.

J Ayu Int Med Sci 2024;9(10)235

Payaam V et al. Jamun: An Alchemy Botanical

28. Dissanayake PK, Wekumbura WG, Wijeratne AW, Wijesundara DS. Morphological characterization, antioxidant capacity and diversity of Syzygium cumini trees from Sri Lanka. Horticultural Plant Journal. 2022 Jan 1;8(1):53-67.
29. Ross IA. Cassia alata. In Medicinal Plants of the World: Volume 1 Chemical Constituents, Traditional and Modern Medicinal Uses.Totowa, NJ: Humana Press 2003; (pp. 165-174).
30. Singh AK, Mishra DS, Sharma BD. Seventy five years of research and development in arid and semi-arid fruit crops. International Journal of Innovative Horticulture. 2022;11(2):214-27.
31. Govindarajan N, Ravichandran L, Chelladurai PK, Pandey A, Murugesan V, Kusuma G. Pharmacopoeial Compliance of Marketed Formulations containing seeds of Syzygium cumini (L.) Skeels. Research Journal of Pharmacy and Technology. 2023;16(12):5823-7.
32. Prasad SB, Gurav AM, Prasad GP. Pharmacognostic and Preliminary Phytochemical Evaluation of Leaf of Syzygium Cumini (L.) Skeels. International Journal of Ayurvedic Medicine. 12(3):684
33. Reynertson KA, Yang H, Jiang B, Basile MJ, Kennelly EJ (2008) Quantitative analysis of antiradical phenolic constituents from fourteen edible Myrtaceae fruits. Food Chem. 2008;109(4):883–890
34. Jamshidi-Kia F, Lorigooini Z, Amini-Khoei H. Medicinal plants: Past history and future perspective. Journal of herbmed pharmacology. 2017 Dec 29;7(1):1-7.
35. Shashank Kumar, S. K., & Pandey, A. K. (2013). Chemistry and biological activities of flavonoids: an overview.
36. Ramos IL, Bandiola TM. Phytochemical screening of Syzygium cumini (myrtaceae) leaf extracts using different solvents of extraction. Der Pharmacia Lettre. 2017;9(2):74-8.
37. Shrikant Baslingappa S, Nayan Singh J T, Meghatai M P, Parag M H. Jamun (Syzygium cumini (L.)): A review of its food and medicinal uses. Food and Nutrition Sciences. 2012 Aug 28; 1101-1104.
38. Veeram Anjali, G. Sindhu, C.Girish .A review on pharmacology and phytochemistry of syzygium cumini. Indian J. Pharm.Biol. Res. 2017; 5(4):24-28
39. M. Jadhav, S.S. Kamble, V.J. Kadam. Herbal medicine: Syzygium Cumini: A Review Journal of Pharmacy Research. 2009;(8): 1212-1219

40. Nicholas J. Walton, Diane E. Brown Chemicals from Plants: Perspectives on Plant Secondary Products. Institute of food Research 0^thedition, Norwich laboratory, UK 1999 March; (1):215-277.
41. Ramteke V, Kurrey V, Kar S. Jamun: A traditional fruit and medicine. Popular Kheti. 2015;3(3):188-90.
42. Ramya S, Neethirajan K, Jayakumararaj R. Profile of bioactive compounds in Syzygium cumini-a review. J. Pharm. Res. 2012 Aug;5(8):4548-53.
43. Benherlal PS, Arumughan C. Chemical composition and in vitro antioxidant studies on Syzygium cumini Journal of the Science of Food and Agriculture. 2007 Nov;87(14):2560-9.
44. Sarma N, Begum T, Pandey SK, Gogoi R, Munda S, Lal M. Chemical composition of Syzygium cumini (L.) Skeels leaf essential oil with respect to its uses from North East region of India. Journal of Essential Oil Bearing Plants. 2020 May 3;23(3):601-7.
45. Gowri J, Vinotha S, Mihiri RJ. Comparative Phyto and Physicochemical Parameters of the Therapeutic Plant Syzygium cumini (L.) Skeels in Jaffna District.2023;26(02)
46. Rajkumar G, Jayasinghe MR, Sanmugarajah V. Comparative Phyto and Physicochemical Parameters of the Therapeutic Plant Syzygium cumini (L.) Skeels in Jaffna District. Vidyodaya Journal of Science. 2023 Dec 31;26(02).
47. Katiyar D, Singh V, Ali M. Recent advances in pharmacological potential of Syzygium cumini: A review. Advances in Applied Science Research. 2016;7(3):1-2.
48. Bahuguna S, Joshi D, Singh B, Semwal N. A Review on Novel Pharmaceutical Approaches of Herbal Drugs in Derma Care. Adermatol & Cosmet JOJ. 2021;4(2):555631.
49. Desai A, Gupta MP. Formulation and evaluation of natural lipstick prepared from java plum extract. World Journal of Pharmaceutical Research. 2023 Jan 18;12(4):1947-58.
50. Jagetia GC. Phytochemical Composition and pleotropic pharmacological properties of jamun, Syzygium cumini skeels. Journal of exploratory research in pharmacology. 2017 May 28;2(2):54-66.
51. Hidayah H, Amal S, Yuniarsih N, Kusumawati AH, Gunarti NS, Abriyani E, Mursal IL, Sundara AK, Alkandahri MY. Sun protection factor activity of Jamblang leaves serum extract (Syzygium cumini). Pharmacognosy Journal. 2023;15(1).

J Ayu Int Med Sci 2024;9(10)236

Payaam V et al. Jamun: An Alchemy Botanical

52. Indonesia JM. Formulasi dan Uji Stabilitas Fisik Sediaan Lip Balm Ekstrak Etanol Buah Coppeng (Syzygium cumini) Sebagai Antioksidan. Jurnal Mandala Pharmacon Indonesia. 2024 Jun 23;10(1):169-80.
53. Kumar M, Zhang B, Nishad J, Verma A, Sheri V, Dhumal S, Radha, Sharma N, Chandran D, Senapathy M, Dey A. Jamun (Syzygium cumini (L.) Skeels) Seed: A Review on Nutritional Profile, Functional food properties, healthpromoting applications, and safety aspects. Processes. 2022 Oct 23;10(11):2169
54. Malik S, Almeida EB, de Andrade Paes AM. Syzygium cumini (L.) Skeels: Cardiometabolic Properties and Potential Tissue Culture-Based Improvement of Secondary Metabolites Production. Transgenesis and Secondary Metabolism. 2016;1-20.
55. Ghosh P, PRadhaN RC, Mishra S, Patel AS, Kar A. Physicochemical and nutritional characterization of jamun (Syzygium cuminii). Current Research in Nutrition and Food Science Journal. 2017 Apr 25;5(1):25-35.
56. Yamaguchi, L.F., Vassão, D.G., Kato, M.J. and Mascio, P. Biflavonoids from Brazilian Pine Araucaria angustifolia as Potentials Protective Agents against DNA Damage and Lipoperoxidation. Phytochemistry, 2005; 66: 2238-2247.
57. Reddy LJ, Jose B. Evaluation of antibacterial and DPPH radical scavenging activities of the leaf extracts and leaf essential oil of Syzygium cumini Linn. from South India. Int J Pharm Pharm Sci. 2013;5(3):1-5.
58. Steffen Arctander Perfume and Flavor Materials of Natural Origin.Elizabeth, N.J (U.S.A) 1996,176.
59. Salunkhe DK, Kadam S, editors. Handbook of fruit science and technology: production, composition, storage, and processing. CRC press; 1995 Aug 18.
60. Weizmann and Y. Mazur, “Steroids and triterpenoids of citrus fruit. II. Isolation of citrostadienol,” The Journal of Organic Chemistry.1958;23(6):832–834.
61. Afifa Jahan .Jamun a fruit with high nutritional and medicinal value. Pharmacogn J. 2023;15(1):134-140.
62. Lima RM, Polonini HC, Brandão MA, Raposo FJ, Raposo NR, Dutra RC. In vitro assessment of anti-aging properties of Syzygium cumini (L.) leaves extract. Biomedical Journal of Scientific & Technical Research. 2019;13(4):10185-91.

63. Assessment of Anti-aging Properties of Syzygium cumini (l.) Leaves Extract. Biomed J Science & Technology Res. January 28,2019.
64. Neetu Gautam, Sakshi Sehgal, Vineet Gupta Rajiv Gupta Hair growth activity of seeds and fruit pulp of Eugenia jambolana(Jamun) Pharm Pharmacol Int J 2015; 2(6): 00039.
65. M Prasad, LESSER KNOWN FRUITS AND VEGETABLES, 1 Edition, Krishna publication house, Gujarat,
66. 2021;54-55.
67. Gautam N, Sehgal S, Gupta V, Gupta R. Hair Growth Activity of Seeds and Fruit Pulp of Eugenia jambolana (Jamun). Pharm Pharmacol Int J. 2015;2(6):00039.
68. Kumar M, Hasan M, Lorenzo JM, Dhumal S, Nishad J, Rais N, Verma A, Changan S, Barbhai MD, Chandran D, Pandiselvam R. Jamun (Syzygium cumini (L.) Skeels) seed bioactives and its biological activities: A review. Food Bioscience. 2022 Dec ;50:102109.
69. Yadav, sudesh kumar A nanobiocomposite formulation for wound healing and a process for the preparation thereof ,wo 2017/122224, European Patent Office
70. Mary kay ,Topical skin care formulations comprising plant extracts us 2020/0323745,USPTO
71. Jacob birnbaum, Hair growth compositions and methods for treating hair loss or related conditions,U.S.2007/0086972,USPTO
72. Krzysztof bojanowski, Methods and compositions for wrinkle reduction and cosmetic lip and facial augmentation ,U.S 9.238,153 b2 ,USPTO

J Ayu Int Med Sci 2024;9(10)237

Review Article

Jamun

Journal of Ayurveda and Integrated Medical Sciences

Jamun: An Alchemy Botanical

Vohra P1*, Redekar K2, Pawar S3, Patil V4

Introduction

Conclusion

References

Vohra P^1*, Redekar K², Pawar S³, Patil V⁴