A Study on Anti Dyslipidemia Activity of Haritaki and Madhu in albino rats treated with high cholesterol diet

Abstract

Dyslipidemia is a disorder of lipoprotein metabolism, including lipoprotein over production or deficiency. Dyslipidemia may be manifested by elevation of total cholesterol, LDL cholesterol and triglycerides concentration and decrease in HDL cholesterol concentration in the blood i.e. presence of one or more than one abnormal serum lipid concentration. Dyslipidemia has becoming one of the major problems leading to various disorders like obesity, diabetes, atherosclerosis, cerebrovascular diseases, hypertension etc. Dyslipidemia is a condition which shares a lot of similarity in pathogenesis and clinical presentation of Medoroga. Medoroga is a condition in which there is abnormal and unequal distribution and collection of Medo Dhatu in body. In the comprehensive Ayurvedic literature Medoroga has been synonymously described as Sthoulya, which has been classified under Ashta Nindita Purusha. The incidence and the magnitude of the problem are constant rise due to alternation in lifestyle with sedentary habits, overeating and stressful life environmental factors etc. The treatment strategy is to implement lifestyle changes including diet and exercise, weight loss and lipid lowering drugs. In spite of availability of numerous drugs, mankind is still leading miserable life with this disease. Hence Ayurveda emphasizes natural and effective remedies which are cost effective and helpful in prevention of the disease. There are variety of drugs mentioned for Medodushti and Atisthoulya. Haritaki and Madhu is one such combination explained in Samhita.