An Overview on the Ornamental Coniferous Tree Cedrus deodara (Roxburgh) G. Don (Himalayan Cedar)
Abstract
Cedrus Deodara (Roxburgh) G. Don is an essential aromatic coniferous tree that belongs to the family Pinaceae. It is commonly called as Himalayan Cedar in English and Devdaar in Hindi and Devdaru in Sanskrit. The leaves of the plant (pine needles) give it an ornamental appearance. It is abundantly found in the Western Himalayan range. The plant has its description in almost each Ayurvedic compendium including Charak Samhita, Sushrut Samhita and Ashthang Hrudya and used against diseases like, respiratory problems, dysentery, diarrhoea, inflammation, eyes and nasal problems, goitre and graves diseases, fever, diarrhoea and urinary disorders etc. In addition, the plant is well used in folkloric practices of disease treatment. The secondary metabolite system of the plant is comprised of alkaloids, flavonoids, phenols, glycosides, resins and tannins still the characteristic feature of the plant is its high essential oil content which is comprised of many important phytoconstituents such as deodarone, alpha pinene, cisocimene, limonene and alpha longipinene etc. Each phytoconstituent is associated with many therapeutic and pharmacological activities such as anti-bacterial, anti-cancer, anti-inflammatory and anti-oxidant etc. Apart from the medicinal value of plant, it provides excellent quality timber and building manufacturing material. The present review is the overall summary of the traditional utilization, phytochemistry and therapeutic significance of Cedrus Deodara.
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Zaman T, Syed MS, Isfaq S, Khan MS. Biological activities of stem, leaves and essential oil of Cedrus deodara from district Poonch, Rawalakot Azad Kashmir, Pakistan. Turkish Journal of Agriculture-Food Science and Technology. 2018 Sep 9;6(9):1114-9.
Thakur S, Kaurav H, Chaudhary G. Nigella sativa (Kalonji): A Black Seed of Miracle. International Journal of Research and Review. 2021;8(4):342-357.
Kumari I, Kaurav H, Chaudhary G. Ethnobotanical Significance of Picrorhiza Kurroa (Kutki), a Threatened Species. International Journal of Research and Review. 2021;8(4):363-75.
Kumari I, Kaurav H, Chaudhary G. Myristica fragrans (Jaiphal): A Significant Medicinal Herbal Plant. International Journal for Research in Applied Sciences and Biotechnology. 2021 Apr 7;8(2):213-24.
Choudhary S, Kaurav H, Chaudhary G. Vaibidang (Embelia ribes): A Potential Herbal Drug in Ayurveda with Anthelmintic Property. International Journal for Research in Applied Sciences and Biotechnology. 2021 Apr 16;8(2):237-43.
Metreveli M, Meskhidze A, Mepharishvili G, Gorgilade L, Koiava L. Antimicrobial Activity of the Himalayan Cedar (Cedrus Deodara Loud.) in Seasonal Dynamics. Bull. Georg. Natl. Acad. Sci. 2020;14(2).
Zhang Z, Lyu X, Xu Q, Li C, Lu M, Gong T, Tang B, Wang L, Zeng W, Li Y. Utilization of the extract of Cedrus deodara (Roxb. ex D. Don) G. Don against the biofilm formation and the expression of virulence genes of cariogenic bacterium Streptococcus mutans. Journal of ethnopharmacology. 2020 Jul 15;257(2020):112856.
Parveen R, Azmi MA, Tariq RM, Mahmood SM, Hijazi MA, Mahmud SH, Naqvi SN. Determination of antifungal activity of Cedrus deodara root oil and its compounds against Candida albicans and Aspergillus fumigatus. Pak. J. Bot. 2010 Oct 1;42(5):3645-9.
Lin CP, Huang JP, Wu CS, Hsu CY, Chaw SM. Comparative chloroplast genomics reveals the evolution of Pinaceae genera and subfamilies. Genome biology and evolution. 2010 Jan 1;2:504-17.
Chaw SM, Sung HM, Long H, Zharkikh A, Lie WH. The phylogenetic positions of the conifer genera Amentotaxus, Phyllocladus, and Nageia inferred from 18S rRNA sequences. Journal of molecular evolution. 1995 Aug 1;41(2):224-30.
Panetsos KP, Christou A, Scaltsoyiannes A. First analysis on allozyme variation in cedar species (Cedrus sp.). Silvae Genetica. 1992;41(6):339-42.
Shinde UA, Phadke AS, Nair AM, Mungantiwar AA, Dikshit VJ, Saraf MN. Membrane stabilizing activity—a possible mechanism of action for the anti-inflammatory activity of Cedrus deodara wood oil. Fitoterapia. 1999 Jun 1;70(3):251-7.
Zeng WC, Jia LR, Zhang Y, Cen JQ, Chen X, Gao H, Feng S, Huang YN. Antibrowning and antimicrobial activities of the water‐soluble extract from pine needles of Cedrus deodara. Journal of food science. 2011 Mar;76(2):C318-23.
Anthwal A, Gupta N, Sharma A, Anthwal S, Kim KH. Conserving biodiversity through traditional beliefs in sacred groves in Uttarakhand Himalaya, India. Resources, Conservation and Recycling. 2010 Sep 1;54(11):962-71.
Mahajan D, Bhat ZF, Kumar S. Pine needles (Cedrus deodara (Roxb.) Loud.) extract as a novel preservative in cheese. Food Packaging and Shelf Life. 2016 Mar 1;7(2016):20-25.
Patel SJ, Lambole V, Shah P, Shah DP. Pharmacological Activities of Cedrus deodara: An Overview. Pharma Science Monitor. 2013 Apr 16;4(3 Suppl 1):100-14.
Agrawal PK, Agarwal SK, Rastogi RP, Österdahal BG. Dihydroflavanonols from Cedrus deodara, A 13C NMR study. Planta medica. 1981 Sep;43(09):82-5.
Bisht A, Jain S, Misra A, Dwivedi J, Paliwal S, Sharma S. Cedrus deodara (Roxb. ex D. Don) G. Don: A review of traditional use, phytochemical composition and pharmacology. Journal of Ethnopharmacology. 2021 Jun 22:114361.
Viswanatha GL, Nandakumar K. Anxiolytic and Anticonvulsant activity of alcoholic extract of heart wood of Cedrus deodara roxb in rodents. Asian Journal of Pharmaceutical Research and Health Care. 2009;1(2):217-239.
Sharma I, Parashar B, Vatsa E, Chandel S, Sharma S. Phytochemical screening and anthelmintic activity of leaves of Cedrus deodara (Roxb.). World J. Pharm. Pharm. Sci. 2016 Jun 15;5(8):1618-28.
Zeng WC, Zhang Z, Jia LR. Antioxidant activity and characterization of antioxidant polysaccharides from pine needle (Cedrus deodara). Carbohydrate polymers. 2014 Aug 8;108(2014):58-64.
Banumathi V. A Review on Siddha Herbal Formulation Deva Chooranam for Improving The QOL in Acquired Immuno Deficiency Syndrome (AIDS). World Journal of Pharmaceutical Research. 2017;6(5):319-332.
Jeeva Gladys R, Kannan KP. Molecular Docking Studies of Deva Chooranam against the Target Protein 6LU7 of Novel Corona Virus 2019. Indo Global Journal of Pharmaceutical Sciences. 2020;10(2):19-25.
Zeng WC, Zhang Z, Jia LR. Antioxidant activity and characterization of antioxidant polysaccharides from pine needle (Cedrus deodara). Carbohydrate polymers. 2014 Aug 8;108(2014):58-64.
Kumar A, Singh V, Chaudhary AK. Gastric antisecretory and antiulcer activities of Cedrus deodara (Roxb.) Loud. in Wistar rats. Journal of ethnopharmacology. 2011 Mar 24;134(2):294-7.
Kar K, Puri VN, Patnaik GK, Sur RN, Dhawan BN, Kulshrestha DK, Rastogi RP. Spasmolytic constituents of Cedrus deodara (Roxb.) Loud: pharmacological evaluation of himachalol. Journal of pharmaceutical sciences. 1975 Feb 1;64(2):258-62.
Zeng WC, He Q, Sun Q, Zhong K, Gao H. Antibacterial activity of water-soluble extract from pine needles of Cedrus deodara. International journal of food microbiology. 2012 Feb 1;153(1-2):78-84.
Ramesh C, Krishnadas N, Radhakrishnan R, Rangappa S, Viswanatha GL, Rajesh D, Gopal M, Talwar S. Anti-urolithiatic activity of heart wood extract of cedrus deodara in rats. Journal of Complementary and Integrative Medicine. 2010 Apr 7;7(1).
Ahmed S, Hasan MM, Mahmood ZA. Antiurolithiatic plants: Multidimensional pharmacology. Journal of Pharmacognosy and Phytochemistry. 2016 Mar 1;5(2):4.
Patil S, Prakash T, Kotresha D, Rao NR, Pandy N. Antihyperlipidemic potential of Cedrus deodara extracts in monosodium glutamate induced obesity in neonatal rats. Indian journal of pharmacology. 2011 Nov;43(6):644.
Singh AP. Promising phytochemicals from Indian medicinal plants. Ethnobotanical leaflets. 2005;2005(1):18.
Shinde UA, Phadke AS, Nair AM, Mungantiwar AA, Dikshit VJ, Saraf MN. Preliminary studies on the immunomodulatory activity of Cedrus deodara wood oil. Fitoterapia. 1999 Aug 1;70(4):333-9.
Singh R, Upadhyay SK, Tuli HS, Singh M, Kumar V, Yadav M, Aggarwal D, Kumar S. Ethnobotany and herbal medicine: Some local plants with anticancer activity. Bulletin of Pure and Applied Sciences. 2020;39(1):57-64.
Marrelli M, Amodeo V, Perri MR, Conforti F, Statti G. Essential Oils and Bioactive Components against Arthritis: A Novel Perspective on Their Therapeutic Potential. Plants. 2020 Oct;9(10):1252.
Tamta S, Palni LM. Studies on in vitro propagation of Himalayan cedar (Cedrus deodara) using zygotic embryos and stem segments. Indian Journal of Biotechnology. 2004;3:209-15.
Khanduri VP, Sharma CM. Pollen production, microsporangium dehiscence and pollen flow in Himalayan cedar (Cedrus deodara Roxb. ex D. Don). Annals of Botany. 2002 May 1;89(5):587-93.
Khanduri VP, Sharma CM. Cyclic pollen production in Cedrus deodara. Sexual plant reproduction. 2009 Jun;22(2):53-61.
Afzal S, Afzal N, Awan MR, Khan TS, Gilani A, Khanum R, Tariq S. Ethno-botanical studies from Northern Pakistan. J Ayub Med Coll Abbottabad. 2009 Mar 1;21(1):52-7.
Hanif M, Khalid AN, Sarwer S. Additions to the Ectomycorrhizae Associated with Himalayan Cedar (Cedrus deodara) using rDNA-ITS. International journal of agriculture & biology. 2012 Feb 1;14(1):101-6.
Manandhar NP. Ethnobotany of Jumla District, Nepal. International Journal of Crude Drug Research. 1986 Jan 1;24(2):81-9.
Gupta S, Walia A, Malan R. Phytochemistry and pharmacology of cedrus deodera: an overview. International Journal of Pharmaceutical Sciences and Research. 2011 Aug 1;2(8):2010.
Jain S, Jain A, Vaidya A, Kumar D, Jain V. Preliminary phytochemical, pharmacognostical and physico-chemical evaluation of Cedrus deodara heartwood. Journal of Pharmacognosy and Phytochemistry. 2014 May 1;3(1):91-5.
Bhardwaj K, Islam MT, Jayasena V, Sharma B, Sharma S, Sharma P, Kuča K, Bhardwaj P. Review on essential oils, chemical composition, extraction, and utilization of some conifers in Northwestern Himalayas. Phytotherapy Research. 2020 Nov;34(11):2889-910.
Sharma S, Sharma S, Pradhan P, Pathak S, Sharma M. Development, standardization of polyherbal formulation of analgesic ointment of plant Carum copticum, Mentha piperita, Cedrus deodara. Journal of Applied Pharmaceutical Research. 2020 Mar 30;8(1):29-43.
Chaudhary AK, Ahmad S, Mazumder A. Cedrus deodara (Roxb.) Loud.: a review on its ethnobotany, phytochemical and pharmacological profile. Pharmacognosy Journal. 2011 Jul 1;3(23):12-7.
Xu F, Gu D, Wang M, Zhu L, Chu T, Cui Y, Tian J, Wang Y, Yang Y. Screening of the potential α-amylase inhibitor in essential oil from Cedrus deodara cones. Industrial Crops and Products. 2017 Sep 1;103(2017):251-6.
Dhaundiyal A, Hanon MM. Calculation of kinetic parameters of the thermal decomposition of residual waste of coniferous species: Cedrus Deodara. Acta Technologica Agriculturae. 2018;21(2):76-81.
Thakur R, Tomar M. Integrated anagement of eedling oot ot of M S R R Cedrus deodara Caused by Binucleate AG-E in Himachal Pradesh Rhizoctonia. J Mycol Pl Pathol. 2020;50(2):168-177.
Shinde UA, Kulkarni KR, Phadke AS, Nair AM, Mungantiwar AA, Dikshit VJ, Saraf MN. Mast cell stabilizing and lipoxygenase inhibitory activity of Cedrus deodara (Roxb.) Loud. wood oil. Indian Journal of Experimental Biology. 1999;37:258-261.
Kadam AA, Singh S, Gaikwad KK. Chitosan based antioxidant films incorporated with pine needles (Cedrus deodara) extract for active food packaging applications. Food Control. 2021 Jun 1;124:107877.
Shivanand P, Viral D, Manish G, Subhash V, Jaganathan K. Formulation and evaluation of cedrus deodara loud extract. Int J Chem Tech Res. 2009;1(4):1145-52.
Selvi S, Devi PU, Chinnaswamy P, Giji TM, Sharmila SP. Antibacterial efficacy and phytochemical observation of some Indian medicinal plants. Ancient science of life. 2007 Jan;26(3):16.
Kumar S, Kumar A, Kumar R. Himalayan (Himachal region) cedar wood (Cedrus deodara: Pinaceae) essential oil, its processing, ingredients and uses: A review. J. Pharmacogn. Phytochem. 2019;8(1):2228-38.
Nam AM, Bighelli A, Ghanmi M, Satrani B, Casanova J, Tomi F. Deodarone Isomers in Cedrus atlantica Essential Oils and Tar Oils. Natural product communications. 2015 Nov;10(11):1905-6.
Bhardwaj K, Silva AS, Atanassova M, Sharma R, Nepovimova E, Musilek K, Sharma R, Alghuthaymi MA, Dhanjal DS, Nicoletti M, Sharma B. Conifers Phytochemicals: A Valuable Forest with Therapeutic Potential. Molecules. 2021 Jan;26(10):3005.
Zhang JM, Shi XF, Ma QH, He FJ, Fan B, Wang DD, Liu DY. Chemical constituents from pine needles of Cedrus deodara. Chemistry of Natural Compounds. 2011 May;47(2):272-4.
Ohmoto T, Kanatani K, Yamaguchi K. Constituent of pollen. XIII. Constituents of Cedrus deodara Loud.(2). Chemical and pharmaceutical bulletin. 1987 Jan 25;35(1):229-34.
Wu YP, Liang X, Liu XY, Zhong K, Gao B, Huang YN, Gao H. Cedrus deodara pine needle as a potential source of natural antioxidants: Bioactive constituents and antioxidant activities. Journal of functional foods. 2015 Apr 1;14:605-12.
Wu Y, Bai J, Zhong K, Huang Y, Qi H, Jiang Y, Gao H. Antibacterial activity and membrane-disruptive mechanism of 3-p-trans-coumaroyl-2-hydroxyquinic acid, a novel phenolic compound from pine needles of Cedrus deodara, against Staphylococcus aureus. Molecules. 2016 Aug;21(8):1084.
Agrawal PK, Rastogi RP. Two lignans from Cedrus deodara. Phytochemistry. 1982 Jan 1;21(6):1459-61.
Liu DY, Shi XF, Wang DD, He FJ, Ma QH, Fan B. Two new myricetin glycosides from pine needles of Cedrus deodara. Chemistry of Natural Compounds. 2011 Nov;47(5):704-7.
Chaudhary A, Sood S, Kaur P, Kumar N, Thakur A, Gulati A, Singh B. Antifungal sesquiterpenes from Cedrus deodara. Planta medica. 2012 Jan;78(02):186-8.
Kumar A, Suravajhala R, Bhagat M. Bioactive potential of Cedrus deodara (Roxb.) Loud essential oil (bark) against Curvularia lunata and molecular docking studies. SN Applied Sciences. 2020 Jun;2(6):1-9.
Saab AM, Gambari R, Sacchetti G, Guerrini A, Lampronti I, Tacchini M, El Samrani A, Medawar S, Makhlouf H, Tannoury M, Abboud J. Phytochemical and pharmacological properties of essential oils from Cedrus species. Natural product research. 2018 Jun 18;32(12):1415-27.
Chung I, Lim J, Yu B, Kim S, Ahmad A. Chemical composition of the essential oil and petroleum ether extract from Korea pine needle leaves of Cedrus deodara. Asian Journal of Chemistry. 2014;26(10):3029-32.
Gao Y, Jin YJ, Li HD, Chen HJ. Volatile organic compounds and their roles in bacteriostasis in five conifer species. Journal of Integrative Plant Biology. 2005 Apr;47(4):499-507.
Lee NH, Lee SM, Lee TM, Chung N, Lee HS. GC-MS analyses of the essential oils obtained from Pinaceae leaves in Korea. Journal of Essential Oil Bearing Plants. 2015 May 4;18(3):538-42.
Chaudhary A, Kaur P, Singh B, Pathania V. Chemical composition of hydrodistilled and solvent volatiles extracted from woodchips of Himalayan Cedrus: Cedrus deodara (Roxb.) Loud. Natural product communications. 2009 Sep;4(9):1257-60.
Choudhary S, Chaudhary G. Sandalwood (Santalum Album): Ancient Tree with Significant Medicinal Benefits. International Journal of Ayurveda and Pharma Research. 2021;9(4):90-9.
Naik HR, Jhadav V. An Ayurvedic Review on Medicinal Inportant of Devdaru Plant. National Journal of Research in Ayurved Science. 2020;8(4):1-4.
Singh PL, Tripathi K, Yadav RB, Yadav KN. Devadaru (Cedrus deodara (Roxb.) Loud.): a critical review on the medicinal plant. Int J Ayurveda Pharm Res. 2014;2(1):1-10.
Joshi Gauri A, Kulkarni Yogini R. Critical Analysis of Pramehaghna dravyas on the basis of Rasapanchaka. Annals of Ayurvedic Med. 2013;2(4):168-75.
Sharma PV. Dravyagun Vigyan. Vol 2. Varanasi, Chaukambha Bharti Academy. 2019.
Mohammad H, Prabhu K, Rao MR, Sundaram RL, Shil S, Vijayalakshmi N. The GC MS study of one Ayurvedic medicine, Khadirarishtam. Research Journal of Pharmacy and Technology. 2019;12(2):535-40.
Khanal H, Joshi RK, Upadhyay A. A Review of an Ayurvedic Polyherbal Formulation Mustadi Kwatha. Journal of Drug Delivery and Therapeutics. 2020 Oct 15;10(5-s):267-72.
Bibi T, Ahmad M, Tareen RB, Tareen NM, Jabeen R, Rehman SU, Sultana S, Zafar M, Yaseen G. Ethnobotany of medicinal plants in district Mastung of Balochistan province-Pakistan. Journal of ethnopharmacology. 2014 Nov 18;157(2014):79-89.
Bhattarai N. Medical ethnobotany in the Karnali Zone, Nepal. Economic Botany. 1992;46(3):257-261.
Kunwar R, Uprety Y, Burlakoti C, Chowdhary C, Bussmann R. Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal. Ethnobotany Research and Applications. 2009;7:5-28.
Kumar M, Paul Y, Anand VK. An ethnobotanical study of medicinal plants used by the locals in Kishtwar, Jammu and Kashmir, India. Ethnobotanical leaflets. 2009;2009(10):1240-56.
Khan M, Kumar S, Hamal IA. Medicinal plants of Sewa River catchment area in the northwest Himalaya and its implication for conservation. Ethnobot. Leafl. 2009;13(2009):1113–1139.
Mehra A, Bajpai O, Joshi H. Diversity, utilization and sacred values of Ethno-medicinal plants of Kumaun Himalaya. Tropical Plant Research. 2014;1(3): 80–86.
Rana CS, Sharma A, Kumar N, Dangwal LR, Tiwari JK. Ethnopharmacology of Some Important Medicinal Plants of Nanda Devi National Park (NDNP) Uttarakhand, India. Nature and Science. 2010;8(11):9-14.
Gamage DG, Dharmadasa RM, Abeysinghe DC, Wijesekara RG, Prathapasinghe GA, Someya T. Emerging Herbal Cosmetic Production in Sri Lanka: Identifying Possible Interventions for the Development of the Herbal Cosmetic Industry. Scientifica. 2021 Mar 10;2021:1-12.
Khan N, Ahmed M, Ahmed A, Shaukat SS, Wahab M, Ajaib M, Siddiqui MF, Nasir M. Important medicinal plants of chitral gol National park (cgnp) Pakistan. Pak. J. Bot. 2011 Apr 1;43(2):797-809.
Kaurav H, Chaudhary S, Chaudhary G. Syzygium cumini (jamun): Antidiabetic fruit plant with significant ayurvedic and therapeutic properties. World Journal of Pharmacy and Pharmaceutical Sciences. 2021;10(6):656-676.
Manikandan PA. Folk herbal medicine: A survey on the paniya tribes of Mundakunnu village of the Nilgiri hills, South India. Ancient Science of life, 2005 Jul; 25(1): 21.
Kumar SP. Adulteration and substitution in endangered ASU medicinal plants of India: a review. Int J Med Arom Plants, 2014 Mar; 4(1): 56- 73.
Thakur S, Walia B, Chaudhary G. Dalchini (cinnamomum zeylanicum): a versatile spice with significant therapeutic potential. International Journal of Pharmaceutics and Drug Analysis. 2021;9(2):126-136.
Kumari I, Chaudhary G, Kaurav H. Folkloric significance of anti-urolithic plant Createva nevula Buch Ham (Varuna). International Journal of Pharmaceutical Science and Health Care. 2021;3(11):7-20.
Thakur R, Bhart C, Panwar K, Arya V. Indigenous volatile oils as imperative gift from nature-a review. International Journal of Ayurveda and Pharma Research. 2018;6(10):54-64.
Kumari I, Chaudhary G. Calotropis procera (Arka): A Tribal Herb of Utmost Significance. International Journal for Research in Applied Sciences and Biotechnology. 2021 May 27;8(3):44-54.
Ramzan M, Obodo RM, Shahzad MI, Mukhtar S, Ilyas SZ, Mahmood T. Green synthesis of Cu@ TiO2 via cedrus deodara leaf extract: A novel composite with high photocatalytic and antibacterial activity. Current Research in Green and Sustainable Chemistry. 2021 Jul 2;4:100137.
Wu Y, Bai J, Liu X, Liu L, Zhong K, Huang Y, Gao H. Antibacterial effect of 3-p-trans-coumaroyl-2-hydroxyquinic acid, a phenolic compound from needles of Cedrus deodara, on cellular functions of Staphylococcus aureus. RSC advances. 2018;8(9):4969-75.
Wu Y, Bai J, Zhong K, Huang Y, Gao H. A dual antibacterial mechanism involved in membrane disruption and DNA binding of 2R, 3R-dihydromyricetin from pine needles of Cedrus deodara against Staphylococcus aureus. Food Chemistry. 2017 Mar 1;218:463-70.
Chandur U, Shashidhar S, Chandrasekar SB, Rao MN. Studies of preliminary phytochemical and anti-arthritic activity of heart wood of Cedrus deodar (Roxb.). RJPBCS. 2011;2(3):654-0.
Manne HS, Basavaraju B, Bindhu V, Keerthi S, Vernekar NN, Laturkar V. Study of Anti-inflammatory and Analgesic Activity of Methnaolic Extracts of Cedrus deodara. Biotechnology An Indian Journal. 2008;2(1):1-4.
Shinde UA, Phadke AS, Nair AM. Studies on the anti-inflammatory and analgesic activity of Cedrus deodara (Roxb.) Loud. Wood oil. Journal of Ethnopharmacology. 1999;65(1):21-7.
XU QD, Zhou ZQ, HE Q, Sun Q, Zeng WC. Antioxidant Activity and Structure-Activity Relationship of Ethanol Extract from Pine Needle of Cedrus deodara. Science and Technology of food industry. 2020 Nov 12;41(20):295-302.
Jain S, Jain A, Malviya N, Kumar D, Jain V, Jain S. Antidiabetic activity of Cedrus deodara aqueous extract and its relationship with its antioxidant properties. Journal of Pharmaceutical Sciences and Pharmacology. 2014 Sep 1;1(3):187-94.
Shi X, Du R, Zhang J, Lei Y, Guo H. Evaluation of the anti-cancer potential of Cedrus deodara total lignans by inducing apoptosis of A549 cells. BMC complementary and alternative medicine. 2019 Dec;19(1):1-7.
Chauhan RS, Joshi A. Anti-Cancer properties of herbs in cell culture system. Journal of Immunology and Immunopathology. 2018;20(si):107-20.
Mashaal K, Perveen R, Zia Z, Mahmood SM, Minhas K, Ibrahim S, Naeem H. Histopathological effects on stomach, liver and kidney associated with Cedrus deodara root oil in ulcer induced rats (Wistar strain). Pakistan Journal of Pharmaceutical Sciences. 2020 Nov 1;33(6):2483-88.
Narayan S, Thakur CP, Bahadur S, Thakur M, Pandey SN, Thakur AK, Mitra DK, Mukherjee PK. Cedrus deodara: In vitro antileishmanial efficacy & immumomodulatory activity. The Indian journal of medical research. 2017 Dec;146(6):780.
Kumar N, Dhayabaran D, Nampoothiri M, Nandakumar K, Lalani AP, Dawood, et al., Atypical Antidepressant Activity of 3,4-Bis(3,4-Dimethoxyphenyl) Furan-2,5-Dione Isolated from Heart Wood of Cedrus deodara, in Rodents. Korean J Physiol Pharmacol. 2014 Oct;18(5):365-369.
Podder S, Pradhan G, Mahapatra SC. Evaluation of petroleum ether heartwood extract of Cedrus deodara in healthy and diabetic rats. Int J Clin Exp Physiol. 2016 Apr 30;3(2):72-6.
Pradhan G, Podder S, Mahapatra SC. Effect of petroleum ether extract of Cedrus deodara on body weight in diabetic rats. International Journal of Clinical and Experimental Physiology. 2016 Jul 1;3(3):140-3.
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