A review on ocular manifestations in Covid-19 and an Ayurvedic overview

  • Athira Rosh Post Graduate Scholar, Department of Shalakya Tantra, Sri Kalabyraveshwara Swamy Ayurvedic Medical College, Hospital and Research Center, Bangalore, Karnataka, India.
  • Veena Shekar Professor, Department of Shalakya Tantra, Sri Kalabyraveshwara Swamy Ayurvedic Medical College, Hospital and Research Center, Bangalore, Karnataka, India.
Keywords: COVID-19, Global Pandemic, Ayurveda, Ocular Manifestations

Abstract

COVID-19 has become a global pandemic from December 2019 resulting in 3.8 million deaths worldwide. The extra pulmonary manifestations of the virus are unpredictable and varied. The ocular manifestations like conjunctivitis, keratitis, uveitis etc. were observed in the patients during the course of the disease, which is being reviewed and summarized in this article. Here an effort is made to collect all the possible data regarding the ocular presentation of COVID-19 and an overview of the disease through Ayurveda.

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References

https://en.wikipedia.org/wiki/COVID-19

Guan W-j, Ni Z-y, Hu Y, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. New England journal of Medicine.2020;382(18):1708-1720.

Han C, Duan C, Zhang S, Spiegel B, Shi H, Wang W, et al. Digestive symptoms in COVID-19 patients with mild disease severity: clinical presenation, stool viral RNA testing, and outcomes. Am J Gastroenterol 2020;115:916-923.

Renu K, Prasanna PL, Valsala Gopalakrishnan A. Coronaviruses pathogenesis, comorbidities and multi organ damage – a review. Life Sci 2020;255:117839.

Loon SC, Teoh SC, Oon LL, Se-Thoe SY, Ling AE, Leo YS, Leong HN. The severe acute respiratory syndrome coronavirus in tears. Br J Ophthalmol.2004 Jul;88(7):861-3 [PMC free article] [PubMed]

Nasiri N, Sharifi H, Bazrafshan A, Noori A, Karamouzian M, Sharifi A. Ocular manifestations of covid-19: a systemic review and metanalysis. J Ophthalmic Vis Res.2021 jan-mar;16(1):103-112[PMC free article][Pubmed]

Van der Hoek L, Pyrc K, Jebbink MF, et al. Identification of new human coronavirus. Nat Med. 2004;10(4):368-373. doi:10.1038/nm1024. [PMC free article] [PubMed]

Seah I, Agarwal R. Can the Coronavirus Disease 2019 (COVID-19) Affect the Eyes? A Review of Coronaviruses and Ocular Implications in Humans and Animals. Ocul Immunol Inflamm.2020 Apr 02;28(3):391-395.[PMC free article] [PubMed]

Wu P, Duan F, Luo C, Liu Q, Qu X, Liang L, Wu Characteristics of Ocular Findings of Patients with Coronavirus Disease 2019 (COVID-19) in Hubei Province, China. JAMA Ophthalmol.2020 May 01;138(5):575-578. [PMC free article] [PubMed]

Noemi Guemes-Villahoz, Barbara Burgos-Blasco and Maria Herrera de la Muela.Connunctivitis in COVID-19 patients: frequency and clinical presentation. Graefes Arch Cli Exp Ophthalmol.2020 Aug 29:1-7. [PMC free article] [PubMed]

Wu P, Liang L, Chen C, et al. A child confirmed COVID-19 with only symptoms of conjunctivitis and eyelid dermatitis. Graefes Arch Clin Exp Ophthalmol 2020; 258(7):1565-1566. [PMC free article] [PubMed]

Katherine Hu; Jay Patel; Cole Swiston; Bhupendra C Patel. Ophthalmic manifestations of coronavirus (covid-19) Statpearls publishing;2021 jan.

Scalinci SZ, Trovato Battagliola E. Conjunctivitis can be the only presenting sign and symptom of COVID-19.ID Cases. 2020;20: e00774. [PMC free article] [PubMed]

Cheema M, Aghazadeh H, Nazarali S, Ting A, Hodges J, McFarlane A, Kanji JN, Zelvas N, Damji KF, Solarte C. Keratoconjunctivitis as the initial medical presentation of the novel coronavirus disease 2019 (COVID-19). Can J Ophthalmol. 2020Aug;55(4): e125-e129. [PMC free article] [PubMed]

Otaif W, Al Somali AI, Al Habash A. Episcleritis as a possible presenting sign of the novel coronavirus disease: A case report. Am J Ophthalmol Case Rep. 2020 Dec;20:100917 [PMC free article] [PubMed]

Méndez Mangana C, Barraquer Kargacin A, Barraquer RI.Episcleritis as an ocular manifestation in a patient with COVID-19.Acta Ophthalmol.2020 Dec;98(8):e1056-e1057. [PMC free article] [PubMed]

Mazzotta C, Giancipoli E. Anterior Acute Uveitis Report in a SARS-CoV-2 Patient Managed with Adjunctive Topical Antiseptic Prophylaxis Preventing 2019-nCoV Spread Through the Ocular Surface Route.Int Med Case Rep J. 2020;13:513-520. [PMC free article] [PubMed]

Marinho PM, Marcos AAA, Romano AC, Nascimento H, Belfort R. Retinal findings in patients with COVID-19. Lancet Lond Engl.2020;395(10237);1610. doi:10.1016/S0140-6736(20)31014-X. [PMC free article] [PubMed]

Invernizzi A, Torre A, Parrulli S, et al. Retinal findings in patients with COVID-19: Results from the SERPICO-19 study. E Clinical Medicine. 2020; doi:10.1016/j.eclinm.2020.100550. [PMC free article] [PubMed]

Lecler A, Cotton F, Lersy F, Kremer S, Heran F ., SFNR’s COVID Study Group. Ocular MRI Findings in Patients with Severe COVID-19: A Retrospective Multicenter Observational Study.Radiology. 2021 May;299(2):E226-E229. [PMC free article] [PubMed]

Wege H, Schluesener H, Meyermann R, Barac-Latas V, Suchanek G, Lassmann H. Coronavirus infection and demyelination: development of inflammatory lesions in Lewis rats. Adv Exp Med Biol. 1998; 440:437-444. [PMC free article] [PubMed]

Luís ME, Hipólito-Fernandes D, Mota C, Maleita D, Xavier C, Maio T, Cunha JP, Tavares Ferreira J. A Review of Neuro-Ophthalmological Manifestations of Human Coronavirus Infection.Eye Brain. 2020;12:129-137. [PMC free article] [PubMed]

Sawalha K, Adeodokun S, Kamoga GR. COVID-19-Induced Acute Bilateral Optic Neuritis. J Investig Med High Impact Case Rep. 2020 Jan-Dec; 8:2324709620976018. [PMC free article] [PubMed]

A K Khurana.Comprehensive Ophthalmology.4th edition.New Delhi. New Age International Pvt. Ltd. Publishers.2007,Pg.140

Charaka Samhita by Agnivesa revised by Charaka and Dridhabala with the Ayurveda Dipika commetary Of Chakrapanidatta, edited by Yadav ji Trikamji Acharya, reprint 2015, Varanasi,Chaukamba Publications.pg 241

Susruta ,Susruta Samhita with the Nibandhasangraha commentary of Sri Dalhanacharya and the Nyayacandrika panjika of Sri Gayadasacharya on Nidanasthana edited by Vaidya Yadavji Trikamji Acharya and Narayan ram Acharya Kavyatirtha, reprint 2014, Varanasi,Chaukamba orientalia.pg 289.

Susruta, Susruta Samhita with the Nibandha sangraha commentary of Sri Dalhanacharya and the Nyayacandrika panjika of Sri Gayadasacharya on Nidanasthana edited by Vaidya Yadavji Trikamji Acharya and Narayan ram Acharya Kavyatirtha, reprint 2014, Varanasi, Chaukamba orientalia.pg 603

Vrddha Vagbhata Astanga samgraha with the Sasilekha Sanskrit commentary by Indu,2nd edition. 2008, Varanasi, Chaukamba Sanskrit Series Office.pg726

Susruta, Susruta Samhita with the Nibandhasangraha commentary of Sri Dalhanacharya and the Nyayacandrika panjika of Sri Gayadasacharya on Nidanasthana edited by Vaidya Yadavji Trikamji Acharya and Narayan ram Acharya Kavyatirtha, reprint 2014, Varanasi, Chaukamba orientalia.pg 603-604

Susruta, Susruta Samhita with the Nibandhasangraha commentary of Sri Dalhanacharya and the Nyayacandrika panjika of Sri Gayadasacharya on Nidanasthana edited by Vaidya Yadavji Trikamji Acharya and Narayan ram Acharya Kavyatirtha, reprint 2014, Varanasi, Chaukamba orientalia.pg633

Aleksandra Tarasiuk., Paula Mosinska., Jakum Fichna. Triphala: current applications and new perspectives on the treatment of functional gastrointestinal disorders.

Adianti M., Aoki C., Komoto M., Deng L., Shoji I., Wahyuni T.S. Anti-hepatitis C virus compounds obtained from Glycyrrhiza uralensis and other Glycyrrhiza species. Microbiol Immunol. 2014;58:180–187.

Huang W., Chen X., Li Q., Li P., Zhao G.N., Xu M.M. Inhibition of intercellular adhesion in herpex simplex virus infection by glycyrrhizin. Cell Biochem Biophys. 2012;62:137–140.

Vaibhav Tiwari, Nissar A Darmani, Beatrice Y J T. Yue, Deepak Shukla. In vitro antiviral activity of neem (Azardirachta indica L.) bark extract against herpes simplex virus type-1 infection. Phytother Res.2010 Aug;24(8):1132-1140

Mohamed A. Nasr-Eldin, Ahmed G. Abdelhamid, Dina M. Baraka Antibiofilm and Antiviral Potential of Leaf Extracts from Moringa oleifera and Rosemary (Rosmarinus officinalis Lam.)

Marc Maurice Cohen. Tulsi - Ocimum sanctum: A herb for all reasons. J Ayurveda Integr Med.2014 Oct-Dec;5(4):251-259.

Morgan R. Jennings, Robin J. Parks. Curcumin as an Antiviral Agent. Viruses. 2020 Nov; 12(11): 1242

Dipti Potdar, R R Hirwani, Sivakami Dhulap. Phytochemical and pharmacological applications of Berberis aristata.

Niyati Acharya, Sanjeev Acharya, Unnati Shah, Ripal Shah, Lal Hingorani. Acomprehensive analysis on Symplocus racemose Roxb.: Traditional uses, botany, phytochemistry and pharmacological activities.

Veena Shekar, Sujathamma K, Hamsaveni V. Management of Disciform keratitis with Ayurvedic ocular therapeutics: A case report. J Clin Ophthalmol 2020;4(1):196-200.

Vrddha Vagbhata Astanga samgraha with the Sasilekha Sanskrit commentary by Indu,2nd edition. 2008, Varanasi, Chaukamba Sanskrit Series Office.pg18

Vrddha Vagbhata Astanga samgraha with the Sasilekha Sanskrit commentary by Indu,2nd edition. 2008, Varanasi, Chaukamba Sanskrit Series Office.pg26-30.

How to Cite
Athira Rosh, & Veena Shekar. (2022). A review on ocular manifestations in Covid-19 and an Ayurvedic overview. Journal of Ayurveda and Integrated Medical Sciences, 6(6), 191 - 198. Retrieved from https://jaims.in/jaims/article/view/1595
Section
Review Article