Comparative clinical study to evaluate the efficacy of Vartaku Gutika and Chitrakadi Vati in the management of Grahani Roga (Irritable Bowel Syndrome)

Abstract

Background: Grahani is a disease of great clinical relevance in modern era because of it’s directly link with improper food habits and stressful lifestyle. Agnimandhya is root cause of Amadosha and it is crucial factor for Grahani and causes Pakwa Apakwa Mala Pravritti. It can be correlated to irritable bowel syndrome. About 15% of the general populations have symptoms that justify diagnosis of IBS. As in the Grahani Agnimandhya is important factor in Samprapti, so it should be treated with Agnivardhan Yogas. Vartaku Gutika which is described in Chakradatta as reseach drug and Chitrakadi Vati mentioned in Charak Samhita for control group. Objectives: To evaluate the effect of Vartaku Gutika and to compare the effect Vartaku Gutika and Chitrakadi Vati in the management of Grahani. Methods: 40 enrolled subjects completed the course of intervention. Randomly they were divided into two groups, group A was given Chitrakadi Vati and group B Vartaku Gutika abd they were adviced 500 mg of tablet two times after food with Ushna Jala, and were adviced to follow Pathya Aahara. Statistical analysis with paired t test, Wilcoxon signed rank test, Mann Whitney test, Mc Nemar test and Chi square test was performed for numerical, ordinal and nominal data respectively. Results: Statistically significant reduction of Lakshana of Grahani in both the group was observed. Overall Vartaku Gutika has more improvement in compared to Chitrakadi Vati. Conclusion: Both Vartaku Gutika and Chitrakadi Vati breaking the pathology of Grahani, but in this study Vartaku Gutika is more effective than compared to Chitrakadi Vati.