An open label single arm clinical study on the effectiveness of Akarakarabha Vati in the management of Klaibya (Erectile Dysfunction)

Abstract

Background: Klaibya (Erectile Dysfunction) is one of the common sexual disorders that affects physical and psychosocial health and may significantly impact the quality of life of sufferers and their partners. Sexual health and function are important determinants of quality of life. Although lifestyle modifications and psychotherapy are considered as the first-line of treatment in Erectile Dysfunction (ED), men presenting with such complaints expect the Ayurveda physician to help them with measures and medication that can have an improved result. Akarakarabaha is a potent drug mentioned in classical textbooks which is having the Shukrasthambaka (inhibition if delayed ejaculation), Balya (strength promoting activity), Vrishya (aphrodisiac), Vajikara properties and it’s having pharmacological activities like antioxidants, aphrodisiac, immunomodulatory effect, antidepressant, anti-diabetic, and effect on testosterone. Methods: Among 11 subjects, 10 of them completed the course of treatment. They were administered with Akarakarabha Vati 500 mg twice a day with milk as Anupana after food for 30 days and 15 days after cessation of medicine. For statistical analysis subjective parameters were assessed with Cochran Q test followed by McNemar test also Friedman's test followed by Wilcoxon sign rank test, and objective parameters were assessed by repeated measure ANOVA followed by Paired t-test. Results: There was statistically significant improvement in the Klaibya Samanya Lakshana and IIEF (International Index of Erectile function) score. Conclusion: Akarakarabaha Vati is effective in the management of Klaibya (Erectile Dysfunction).