A comprehensive review of Aconitum heterophyllum
Abstract
Aconitum heterophyllum, commonly known as Ativisha or Indian Atees, is a perennial herbaceous plant with a rich history of use in traditional medicine systems across Asia, particularly in Ayurveda and Traditional Chinese Medicine (TCM). Traditional medicine systems have utilized Aconitum heterophyllum for centuries to treat various health conditions, including fever, digestive disorders, respiratory ailments, and pain-related conditions. It is also known for its antipyretic, analgesic, anti-inflammatory, and sedative properties, among others. The pharmacological activities of Aconitum heterophyllum are attributed to its bioactive compounds. Studies have demonstrated its analgesic and anti-inflammatory effects, along with antipyretic and immunomodulatory properties. It has also shown promising antimicrobial activity and potential as an anticancer agent. However, safety concerns arise due to the presence of toxic alkaloids, particularly aconitine, which can be harmful if not properly processed or used in excessive amounts. Traditional preparation methods, such as boiling and purification, are employed to reduce toxicity and enhance safety. This review emphasizes the importance of cautious and responsible use of Aconitum heterophyllum in medicinal practices. While its therapeutic potential holds promise for various health conditions, further research is required to validate its efficacy and safety for modern medical applications. By bridging traditional knowledge with modern scientific investigations, this review aims to contribute to the understanding of Aconitum heterophyllum's medicinal properties and its potential role in modern medicine. The synthesis of traditional wisdom and contemporary research findings underscores the significance of this ancient medicinal plant as a valuable resource for natural medicine and drug development.
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Atal 1. Anwar S, Ahmad B, Sultan M, Gul W, Islam N. Biological and pharmacological properties of Aconitum chasmanthum. J Biol Sci. 2003;3:989-93.
Atal CK, Sharma ML, Kaul A, Khajuria A. Immunomodulating agents of plant origin. I: preliminary screening. J Ethnopharmacol. 1986;18:133-41.
Pandey H, Nandi SK, Kumar A, Palni UT, Chandra B, Palni LMS. In vitro propagation of Aconitum balfourii Stapf.: an important aconite of the Himalayan alpines. J Hortic Sci Biotechnol. 2004;79:34-41.
Liu FX, Sun S, Cui ZZ. Analysis of immunological enhancement of immunosuppressed chickens by Chinese herbal extracts. J Ethnopharmacol. 2010;127:251-6.
Gupta A, Jagtap RB, Chaphalkar SR. Anti-viral activity of Azadirachta indica leaves against Newcastle disease virus: a study by in vitro and in vivo immunological approach. Int J Curr Trends Pharm Res. 2014;2(6):494-501.
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Verma S, Ojha S, Raish M. Anti-inflammatory activity of Aconitum heterophyllum on cotton pellet-induced granuloma in rats. J Med Plants Res. 2010;4(15):1566-9.
Nautiyal BP, Nautiyal MC, Khanduri VP, Rawat N. Floral biology of Aconitum heterophyllum Wall.: a critically endangered alpine medicinal plant of Himalaya, India. Turk J Bot. 2009;33:13-20.
Talreja S, Tiwari D. Do you think disease and disorder are the same? – here is the comparative review to brush up your knowledge. J Pharm Sci Res. 2023;12:462-468.
Gajalakshmi S, Jeyanthi P, Vijayalakshmi S, Devi Rajeswari V. Phytochemical constituent of Aconitum species-a review. Int J Appl Biol Pharm Technol. 2011;2(4):121-7.
Srivastava N, Sharma V, Dobriyal AK, Kamal B, Gupta S, Jadon VS. Influence of pre-sowing treatments on in vitro seed germination of ativisha (Aconitum heterophyllum Wall. ex Royle) of Uttarakhand. Biotechnology. 2011;10:215-9.
Zhao Y, Bu Q, Zhou Y, Lv L, Yan G, Chen B, et al. Mechanism study of Aconitum-induced neurotoxicity in PC12 cells: involvement of dopamine release and oxidative damage. Neurotoxicology. 2010;31:752-7.
Singhuber J, Zhu M, Prinz S, Kopp B. Aconitum in traditional Chinese medicine: a valuable drug or an unpredictable risk? J Ethnopharmacol. 2009;126:18-30.
Shastri MR V. Sachittar Ayurveda. 1964;19:134.
Benamar H, Rached W, Derdour A, Marouf A. Screening of Algerian medicinal plants for acetylcholinesterase inhibitory activity. J Biol Sci. 2010;10:1-9.
Razavi SM. Plant coumarins as allelopathic agents. Int J Biol Chem. 2011;5(1):86-90.
Ouattara L, Koudou J, Zongo C, Barro N, Savadogo A, Bassole IHN. Antioxidant and antibacterial activities of three species of Lannea from Burkina Faso. J Appl Sci. 2001;11(1):157-62.
Pereira JA, Oliveira I, Sousa A, Valentão P, Andrade PB, Ferreira IC, et al. Walnut (Juglans regia L.) leaves: phenolic compounds, antibacterial activity and antioxidant potential of different cultivars. Food Chem Toxicol. 2007;45:2287-95.
Verma S, Ojha S, Raish M. Anti-inflammatory activity of Aconitum hetrophyllum on cotton pellet-induced granuloma in rats. J Med Plants Res. 2010;4(15):1566-9.
Chopra IC, Kohli JD, Handa KL. Ind J Med Res. 1945;33:157.
Anwar S, Ahmad B, Sultan M, Gul W, Islam N. Biological and pharmacological properties of Aconitum chasmanthum. J Biol Sci. 2003;3:989-93.
Talreja S, Tiwari D. A Pharmaceutical And Pharmacological Study Of Ficus Religiosa: A Systematic Review. Int J Pharm Technol. 2020;12:7109-7121. DOI:10.32318/IJPT/0975-766X/12(3).7109-7121.
Rastogi R.P, Mehrotra B.N. Compend, Indian Med Plant. 1993;2:10.
Patel DK, Amin KS, Nanavati DD. Drugs. 1995;32:566.
Talreja S, Tiwari D. Insomnia: A Study on Sleeping Disorder with the Reference of Ayurvedic Herbs. J Pharm Sci Res. 2020;12:1375-1379.
Atal CK, Sharma ML, Kaul A, Khajuria A. Immuno modulating agents of plant origin. I: preliminary screening. J Ethnopharmacol. 1986;18:133-41.
Pandey H, Nandi SK, Kumar A, Palni UT, Chandra B, Palni LMS. In vitro propagation of Aconitum balfourii Stapf.: an important aconite of the Himalayan alpines. J Hortic Sci Biotechnol. 2004;79:34-41.
Liu FX, Sun S, Cui ZZ. Analysis of immunological enhancement of immunosuppressed chickens by Chinese herbal extracts. J Ethnopharmacol. 2010;127:251-6.
Gupta A, Jagtap RB, Chaphalkar SR. Anti-viral activity of Azadirachta indica leaves against Newcastle disease virus: a study by in vitro and in vivo immunological approach. Int J Curr Trends Pharm Res. 2014;2(6):494-501.
CK, Sharma ML, Kaul A, Khajuria A. Immunomodulating agents of plant origin. I: preliminary screening. J Ethnopharmacol 1986; 18: 133-41.
Pandey H, Nandi SK, Kumar A, Palni UT, Chandra B, Palni LMS. In vitro propagation of Aconitum balfourii Stapf.: an important aconite of the Himalayan alpines. J Hortic Sci Biotechnol 2004; 79: 34-41.
Liu FX, Sun S, Cui ZZ. Analysis of immunological enhancement of immunosuppressed chickens by Chinese herbal extracts. J Ethnopharmacol 2010; 127: 251-6.
Gupta A, Jagtap RB, Chaphalkar SR. Anti-viral activity of Azadirachta indica leaves against Newcastle disease virus: a study by in vitro and in vivo immunological approach. Int J Curr Trends Pharm Res 2014; 2(6): 494-501.
Benamar H, Rached W, Derdour A, Marouf A. Screening of Algerian medicinal plants for acetylcholinesterase inhibitory activity. J Biol Sci 2010; 10: 1-9.
Tiwari, Dr & Talreja, Shreya. (2021). Concept of Health Across Different Ages: A Review. Asian Journal of Pharmaceutical Research and Development. 9. 10.22270/ajprd.v9i2.940.
Razavi SM. Plant coumarins as allelopathic agents. Int J Biol Chem 2011; 5(1): 86-90.
Ouattara L, Koudou J, Zongo C, Barro N, Savadogo A, Bassole IHN. Antioxidant and antibacterial activities of three species of Lannea from Burkina Faso. J Appl Sci 2001; 11(1): 157-62.
Pereira JA, Oliveira I, Sousa A, Valentão P, Andrade PB, Ferreira IC, et al. Walnut (Juglans regia L.) leaves: phenolic compounds, antibacterial activity and antioxidant potential of different cultivars. Food Chem Toxicol 2007; 45: 2287-95.
Wangchuk P, Bremner JB, Samten, Skelton BW, White AH, Rattanajak R, et al. Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum. J Ethnopharmacol 2010; 130: 559-62.
Verma S, Ojha S, Raish M. Anti-inflammatory activity of Aconitum heterophyllumon cotton pellet-induced granuloma in rats. J Med Plants Res 2010; 4(15): 1566-9.
Nautiyal BP, Nautiyal MC, Khanduri VP, Rawat N. Floral biology of Aconitum heterophyllum Wall.: a critically endangered alpine medicinal plant of Himalaya, India. Turk J Bot 2009; 33: 13-20.
Talreja, Shreya & Tiwari, Dr. (2023). Do you think disease and disorder are same? –here is the comparative review to brash up your knowledge. Journal of Pharmaceutical Sciences and Research. 12. 462-468.
Gajalakshmi S, Jeyanthi P, Vijayalakshmi S, Devi Rajeswari V. Phytochemical constituent of Aconitum species-a review. Int J Appl Biol Pharm Technol 2011; 2(4): 121-7.
Srivastava N, Sharma V, Dobriyal AK, Kamal B, Gupta S, Jadon VS. Influence of pre-sowing treatments on in vitro seed germination of ativisha (Aconitum heterophyllum Wall. ex Royle) of Uttarakhand. Biotechnology 2011; 10: 215-9.
Zhao Y, Bu Q, Zhou Y, Lv L, Yan G, Chen B, et al. Mechanism study of Aconitum-induced neurotoxicity in PC12 cells: involvement of dopamine release and oxidative damage. Neurotoxicology 2010; 31: 752-7.
Singhuber J, Zhu M, Prinz S, Kopp B. Aconitum in traditional Chinese medicine: a valuable drug or an unpredictable risk? J Ethnopharmacol 2009; 126: 18-30.
Shastri, M.R V. Sachittar Ayurveda 1964; 19: 134.
Benamar H, Rached W, Derdour A, Marouf A. Screening of Algerian medicinal plants for acetylcholinesterase inhibitory activity. J Biol Sci 2010; 10: 1-9.
Razavi SM. Plant coumarins as allelopathic agents. Int J Biol Chem 2011; 5(1): 86-90.
Ouattara L, Koudou J, Zongo C, Barro N, Savadogo A, Bassole IHN. Antioxidant and antibacterial activities of three species of Lannea from Burkina Faso. J Appl Sci 2001; 11(1): 157-62.
Pereira JA, Oliveira I, Sousa A, Valentão P, Andrade PB, Ferreira IC, et al. Walnut (Juglans regia L.) leaves: phenolic compounds, antibacterial activity and antioxidant potential different cultivars. Food Chem Toxicol 2007; 45: 2287-95.
Verma S, Ojha S, Raish M. Anti-inflammatory activity of Aconitum hetrophyllum on cotton pellet-induced granuloma in rats. J Med Plants Res 2010; 4(15): 1566-9.
Chopra, I.C Kohli, J.D and Handa, K.L., Ind J Med Res 1945; 33:157.
Anwar S, Ahmad B, Sultan M, Gul W, Islam N. Biological and pharmacological properties of Aconitum chasmanthum. J Biol Sci 2003; 3: 989-93.
Tiwari, Dr & Talreja, Shreya. (2020). A Pharmaceutical And Pharmacological Study Of Ficus Religiosa: A Systematic Review. International Journal of Pharmacy and Technology. 12. 7109-7121. 10.32318/IJPT/0975-766X/12(3).7109-7121.
Rastogi R.P and Mehrotra B.N Compend, Indian Med Plant 1993; 2:10.
Patel, D.K Amin K.S and Nanavti D.D. Drugs 1995; 32: 566.
Tiwari, Dr & Talreja, Shreya. (2020). Insomnia: A Study on Sleeping Disorder with the Reference of Ayurvedic Herbs. Journal of Pharmaceutical Sciences and Research. 12. 1375-1379.
Atal CK, Sharma ML, Kaul A, Khajuria A. Immuno modulating agents of plant origin. I: preliminary screening. J Ethnopharmacol 1986; 18: 133-41.
Pandey H, Nandi SK, Kumar A, Palni UT, Chandra B, Palni LMS. In vitro propagation of Aconitum balfourii Stapf.: an important aconite of the Himalayan alpines. J Hortic Sci Biotechnol 2004; 79: 34-41.
Liu FX, Sun S, Cui ZZ. Analysis of immunological enhancement of immunosuppressed chickens by Chinese herbal extracts. J Ethnopharmacol 2010; 127: 251-6.
Gupta A, Jagtap RB, Chaphalkar SR. Anti-viral activity of Azadirachta indica leaves against Newcastle disease virus: a study by in vitro and in vivo immunological approach. Int J Curr Trends Pharm Res 2014; 2(6): 494-501.
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