Vernonia amygdalina Del (Bitter leaf) a traditional anti-diabetic gold mine - Mini Review

  • Peter Achunike Akah Natural Products Research Unit, Department of Pharmacology and Toxicology, University of Nigeria, Nigeria.
Keywords: Vernonia amygdaina, diabetes mellitus, traditional uses, mechanism of action


Diabetes mellitus is a worldwide epidemic that has serious consequences for public health. This in-depth analysis of Vernonia amygdalina, or Bitter Leaf, aims to shed light on the plant's potential anti-diabetic properties by discussing its botanical description, chemical composition, traditional uses, and mechanisms of action, scientific findings, safety concerns, and implications for future study. Vernonia amygdalina, a plant native to various nations in Africa, has gained popularity as a possible treatment for diabetes. Bitter leaf's traditional function in reducing diabetes-related complications is also highlighted, and the review goes deeply into the plant's rich historical and cultural context. The possible anti-diabetic properties of Bitter leaf are discussed, along with the processes that may be at play. These include the effect on insulin sensitivity, glucose homeostasis, and pancreatic beta cell activity. Improving glycemic control and insulin resistance is only two of the positive effects seen in clinical trials and research investigations. There is also discussion of precautions to take, including details on how this treatment could interact with standard drugs. The review continues by stressing the need for more study to fill up the gaps in our understanding and pave the path for the deliberate application of Vernonia amygdalina as an adjunctive method of diabetes care. This analysis of Bitter leaf's diabetes-fighting properties adds to the increasing body of information around diabetes natural treatments, opening up new lines of inquiry and possible therapeutic applications in the field.


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Ogurtsova. K., da Rocha-Fernades, J.D., Huang, Y. Cavan D, Shaw JE, Makaroff LE Global estimates of the prevalence of diabetes. Diab Res Clil Pract 2017;128: 40-50.

IfedibaluChukwu EI, Aparoop D, Kamaruz Z. Antidiabetic, anthelmimtic and antioxidation properties of novel and new phytocompounds isolated from the methanolic stem-bark of Vernonia amygdalina Delile (Asteraceae). Scientific African 2020; 10. doi:10.1016/j.sciaf.2020.e00578.

Habtama, A. and Melaku, Y. Antibacterial and antioxidant compounds from the flower extracts of Vernonia amygdalina Adv Pharmacol Sci. 2018 doi: 10.1155/2018/4083736.

Tekou, FA, Kuate D, Nguekouo PT, Woumbo CY, Oben JE. Effect of cooking treatments on the phytochemical composition snd antidiabetic potentials of Vernonia amygdalina. Food Sci Nutr 2018; 6(6): 1684-1691. doi:10.1002fsn3.732.

Ijeh II, Ejike CECC (2011).Current perspectives on the medicinal potentials of Vernonia amygdalina Del. J Med Plants Res 2011; 5 (7): 1051-1061.

Ugbogu EA, Emmanuel O, Dike ED, Agi GO, Ugbogu OC, Ibe C, Iweala EJ. The phytochemistry, ethnobotanical, andpharmacological potentials of the medicinal plant-Vernonia amfgdalina, (bitter leaf). Clin Compl Med Pharmacol 2021; 1: 1000006.

Akah PA, Okafor CL. Blood sugar lowering effect of Vernonia amygdalina Del in experimental rabbit model. Phytother Res 1992; 6 (3): 171-173.

Masaba SC. The antimalarial activity of Vernonia amygdalina Del (Compositae). Trans Royal Soc Tropl Med Hyg 2000; 94(6): 694-695. doi: 10.1016/s0035-9203(00)90236-0.

Ogboli AU, Nock IH, Abdurahman EM, Ibrahim NDG. Medicinal application of Vernonia amygdalina Del leaf extracts in treatment of schistosomiasis in mice. Nig J Nat Prod Med 2000; 4: 73-75.

Njan AA, Adzu B, Agaba AG, Byarugaba D, Diaz-Llera S,Bangsberg DR. The analgesic and antiplasmodial activities and toxicology of Vernonia amygdalina. J Med Foods 2008; 11 (3): 574-581. doi: 10.1089/jmf.2007.0511.

Akah PA, Ekekwe RK. Ethnopharmacology of some of the asteraceae family used in the Nigerian traditional medicine. Fitoterapia 1995; 66: 352-355.

Nwanjo HU, Nwokoro EA. Antidiabeic and biochemical effects of aqueous extract of Vernonia amygdalina leaf in normoglycemic and diabetic rats, J Innov Life Sci 2004; 7: 6-10.

Okolie UV, Okeke CE, Ehiemere IO. Hypoglycemic indices of Vernonia amygdalina on post-prandial blood glucose concentration of healthy humans. Afr J Biotechnol 2008; 7: 4581-4585.

Ogbuokiri JE, Ekpechi D. Anti-hyperglycaemic activity of Vernonia Americana on healthy adult volunteers. Clin Pharm Herbal Med 1989; 5(3): 39-42.

Challand S, Willoox M. A clinical trial of the traditional medicine Vernonia amygdalina in treatment of complicated malaria. J Altern Compl Med 2009; 15 (11). doi: 10.1089.acm.2009.0098.

Owen TA, Amakiri OJ, Karibi-Botoye AO. Sugar lowering effect of bitter leaf (Vernonia amygdalina) in experimental broiler finisher chickens. Asian J Pharmaceut Clin Res 2011; 4: 19-21.

Igile GO, Oleszek W. Burda S. Jurzysta M. Nutritional assessment of Vernonia amygdalina leaves in growing mice. J Agr Food Chem 1995; 43: 2162-2166.

Farombi OF, Owoeye O. Antioxidant and chemopreventive properties of Vernonia amygdalina and Garcinia biflavonoid. Intern J Res Publ Health 2011; 8: 2533-2555. doi: 10.3390/ijerph8062533.

Igile GO, Oleszek W. Jurzysta M, Burda S, Fafunso M, Fasanmade AA (1994), Flavonoids from Vernonia amygdalina and their antioxidant activities. J Agr Food Chem 1994; 42: 2445-2448.

Jisaka M, Ohigashi H, Takagaki T, Nozaki H, Tada T, Hirota M, Irie R, Huffman MA, Nishida T, Kaji M, Koshimizu K. Bitter steroids glucosides, vernoniosdies Ai, A2, and A3, and related B1 from a possible medicinal plant Vernonia amygdalina used by wild chimpanzees. Tetrahedron 1992; 48: 625-632.

Kupchan SM, Hemmnigway RJ, Karim A, Werner D. Tumor inhibitors, XLVII vernodalin and vernomygdin. Twonew cytotoxic sesquiterpene lactones from Vernonia amygdalina Del. J Org Chem 1969; 34: 3908-3911.

Ganjian I, Kubo I, Fludzinski P . Insect antifeedant elemanolide lactone from Vernonia amygdalina. Phytochemistry 1983; 22: 2525-2526.

Erasto P, Grierson DS, Afolayan AJ. Bioactive sesquiterpene lactones vrom the leaves of Vernonia amygdalina. J Ethnopharmacol 2006; 106 (1): 117-120. doi: 10.1016/j.jep.2005.12.016.

Jisaka M, Ohigashi H, Takagaki T, Hirota M, Irie R, Huffman MA, Koshimizu K. Steroids glucosides, from Vernonia amygdalina a possible chimpanzees plant. Phytochemistry 1993; 34: 409-413.

Owoeye O, Yousuf S, Akhtar MN, Qamar K, Dar A, Farombi EO, Onwuka SK, Choudhary MI. Another anticancer elemanolide fromVernonia amygdalina Del, Intern J Biol Chem Sci 2010; 4: 226-234.

Toyang NJ, Verpoorte RA. A review of the medicinal potentials of plants of the genus Vernonia (Asteraceae). J Ethnopharmacol 2013; 146: 681-723. doi:10.1016/j.jep.2013.01/040.

Jayaweera U, Akowuah GA, Ling CY, Kumar PV, Herapathdeniya S. Diabetes and Vernonia amygdalina Delile (Aateraceae). Biointer Res Appl Chem 2022; 12 (4) : 4496-4517.

Kamperdick C, Breitmaier E, Radloff MA. A new steroid saponins from Vernonia amygdalina Del (Compositae). J Prakt Chem 1992; 334: 425-428.

Saliu JA, Ademiluyi AO, Akinyemi AJ, Oboh C. Invitro antidiabetic and antihypertensive properties of phenolic extracts from bitter leaf (Vernonia amygdalina) Del. J Food Biochem 2012; 36: 569-576.

Ong KW, Hsu A, Song L, Huang D, Tan BKH. Polyphenols-rich Vernonia amygdalina shows anti-diabetic effects in streptozotocin-induced diabetic rats. J Ethnopharmacol 2011; 133: 596-607. doi: 10. 1016/j.jep.2010.10.046.

Atangwho IJ, Yin KB, Umar MI, Ahmad M, Asmawi M. Vernonia amygdalina simultaneously suppresses gluconeogenesis and potentiates glucose oxidation via the pentose phosphate pathway in streptozotocin-induced diabetic rats. BMC Compl Altern Med 2014; 14: 1-13. doi: 10.1186/1472-6882.14-426.

Edet A, Ebong P, Eseyin O, Udoh I, Eyo R. Anti-diabetic effect and RNA content of the pancreas of Albino Wistar rats treated with aqueous extract of Vernonia amygdalina roots. Intern J Pharma Sci 2013; 3: 391-393.

Atangwho IJ, Ebong EE, Egbung E, Augustine O. Extract of Vernonia amygdalina Del (African bitter leaf) can reverse pancreatic cellular lesion after alloxan damage in the rats. Aust J Basic Appl Sci 2010; 4 (5): 711-716.

Iwalokun BA, Efedede BU, Alabi-Sofunde JA,Oduala T, Magbagbeola OA, Akinwande AI. Hepatoprotective and antioxidant activities of Vernonia amygdalina on acetaminopnen-induced hepatic damage in rats. J Med Foods 2006; 9(4): 524-530. doi:10.1089/jmf.2006.9/524.

Adesanoye OA, Farombi EO. In vitro antioxidant properties of methanolic leaf extract of Vernonia amygdalina Del. Nig J Physiol Sci 2014; 29 2 :93-101.

Prananda AT, Dalimunthe A, Harahap U, Syahputra RA, Nugraha SE, Situmonrang PC, Fah YT, Velano AJ, Bilakaya B, Harahap MAY. Venonia amygdalina prevents against doroxubicin-induced hepatic and renal damage in rats: mechanistic insights. Pharmacia 2023; 70 (3): 825-835. doi 10.3897/pharmacia.70.e112425.

Nguyen TXT, Dang DL, Ngo VQ, Trinh TC, Trinh QN, Do TD, Thanh TTT. Anti-inflammatory activity of a new compound from Vernonia amygdalina. Nat Prod Res 2020; 1-6. doi:10.1080/14786419.2020.1788556

Ezekwe CI, Obidoa O. Biochemical effects of ernonia amygdalina on rats liver microsomes. Nig J Biochem Mol Biol 2001; 16: 174S-179S.

Akah PA, Alemji JA, Salawu OA, Okoye TC, Offiah VN. Effects of Vernonia amygdalina on biochemical and hematological parameters in diabetic rats. Asian J Med. Sci 2009; 1(3): 108-113.

Yeap SK, Liang WS, Beh BK, Ho WY, Yousr AN, Alitheen NB. In vivo antidiabetic and acute toxicity of spray-dried Vernonia amygdalina water extract. Intern Food Res J 2013; 20 (2}: 613-616.

Nabukenya I, Rubaire-Akiiki C, Mugizi D, Kateregga J, Olilia D. Subacute toxicity of aqueous extracts of Tephrosia vogelii, Vernonia amygdalina and Senna occidentalis in rats. Nat Prod Chem Res 2014; 2 (5): 143. doi; 10.4172/2429-6836.1000143.

Oyeyemi MO, Soetan KO, Akinkpelu OB. Sperm characteristics and haemogram of male albino rats treated with saponin extract of Vernonia amygdalina Del Asteraceae. J Cell Animal Biol 2015; 9 (3): 26-30.

Owu Du, Ben EE, Antai AB, Ekpe EA, Udia P. Stimulation of gastric acid secretion and intestinal motility by Vernonia amygdalina extract. Fitoterapia 2008; 79: 97-100.

Osinubi. Effects of Vernonia amygdalina and chlopropamide on blood glucose. Medical J Islamic World Acad Sci 1996; 16: 115-119.

Taiwo IA, Odeigah PGC, Ogunkanmi LA (2009). The glycaemic effects of Vervonia amygdalina and V. tenoreana with tolbutamide in rats and the implications for the treatment of diabetes mellitus. J Scientific Res Dev 2009; 11: 122-130.

Adikwu MU, Uzuegbu DB, Okoye TC, Uzor PF, Adibe MO, Amadi BV. Antidiabetic effect of combined aqueous leaf extract of Vernonia amygdalina and metformin in rats. J Basic Clin Pharm 2010; 1(3):197-202.

Dorathy UN, Charles EO, Umaru AM. Effects of capsules of Vernonia amygdalina combined with glibenclamide or metformin on blood glucose levels of diabetic rats. Intern J Pharmaceut Sci Rev Res 2017; 44: 9-14.

DOI: 10.21760/jaims.9.1.24
Published: 2024-02-24
How to Cite
Peter Achunike Akah. (2024). Vernonia amygdalina Del (Bitter leaf) a traditional anti-diabetic gold mine - Mini Review. Journal of Ayurveda and Integrated Medical Sciences, 9(1), 170 - 175.
Review Article