An experimental evaluation of Anti-Inflammatory and Analgesic Activity of Allium Cepa Linn. and Allium Ascalonicum Linn. - A comparative study

Aby Mathew Jose; Akhila Vinod

doi:10.21760/jaims.9.5.7

Aby Mathew Jose Assistant Professor, Dept. of Dravyaguna, Babe Ke Ayurvedic Medical College and Hospital, Punjab, India.
Akhila Vinod Assistant Professor, Dept. of Agadatantra, Dayanad Ayurvedic Medical College and Hospital, Punjab, India.

DOI: https://doi.org/10.21760/jaims.9.5.7

Keywords: Allium cepa Linn, Allium ascalonicum Linn, Anti-inflammatory, Analgesic

Abstract

Introduction: The drugs possessing Vataghna property are much indicated in classics for managing Shotha and Vedana. Cost-effective, widely available, and potent drugs should be encouraged over costly ones. The present study was undertaken based on this, focusing on the bulb of Allium cepa Linn. & Allium ascalonicum Linn. to evaluate the anti-inflammatory and analgesic activities employing carrageenan induced paw oedema in wistar albino rats and hotplate tests in mice, respectively. Materials and Methods: Fresh juice of Allium cepa Linn. and Allium ascaloncum Linn. was given to rats and mice orally to observe anti-inflammatory and analgesic activity, and observed for a day. Anti-inflammatory activity was evaluated using carrageenan induced paw edema model in wistar albino rats. Analgesic activity was evaluated using Hot plate method in mice. Experimental animals were divided into 4 groups, Group A as control was given distilled water and; Group B with standard drug, Paracetamol suspension, Group T 1 as test drug 1 with Swarasa of Allium cepa Linn; and Group T 2 as test drug II with Swarasa of Allium ascalonicum Linn. as per the calculated doses respectively. Results: Animals treated with the test drugs showed a significant reduction in paw oedema and had analgesic effects compared to the control group. The result obtained was also assessed by a one-way-ANOVA test. Discussion: The experiment concludes that both the test drugs have anti-inflammatory and analgesic capabilities. However, anti-inflammatory and analgesic effect was seen better in Allium ascalonicum Linn. than Allium cepa Linn. No adverse effects were noted in the study.

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