Clinical Assessment of Efficacy and Safety of Addyzoa Tablet in Male Infertile Patients with Oligospermia and Asthenospermia

Dnyaneshwar Mote; Vipul Jaiswal; Nagsen Punekar

doi:10.21760/jaims.9.6.3

Dnyaneshwar Mote Principal Investigator, Vidnyanam Clinic, Opp. Indian oil Petrol Pump, Katraj-Kondhwa Road, Katraj, Pune, Maharashtra, India.
Vipul Jaiswal Co-Investigator, Vidnyanam Clinic, Opp. Indian oil Petrol Pump, Katraj-Kondhwa Road, Katraj, Pune, Maharashtra, India.
Nagsen Punekar Co-Investigator, Vidnyanam Clinic, Opp. Indian oil Petrol Pump, Katraj-Kondhwa Road, Katraj, Pune, Maharashtra, India.

DOI: https://doi.org/10.21760/jaims.9.6.3

Keywords: Oligospermia, Asthenospermia, Density, Male infertility, M. pruriens, Motility, W. sominifera.

Abstract

Infertility is defined as inability of a sexually active couple to conceive after 1 year of regular intercourse without contraception. Male factors account for 20%-50% of cases of infertility. Male infertility is primarily caused by low sperm count (Oligospermia) and reduced sperm motility (asthenospermia), and is an issue of global dimensions. Oligospermia in a clinically healthy man is one of the commonest conditions encountered in an infertility clinic. Medical management of oligospermia lags far behind expectations, and is still in experimental stage. The global deterioration of male reproductive health is of a major concern. The modern therapeutic approaches to combat male infertility are expensive, less accessible, have long term treatment tenure and possess various side effects. Whereas, the herbal therapies, are better positioned to offer more holistic approaches to improve male reproductive health. The present study was carried out to evaluate the efficacy and safety of Addyzoa Tablet manufactured by Charak Pharma Pvt. Ltd., an herbal formula comprising of extracts of Withania somnifera, Tribulus terrestris, Mucuna pruriens, Chlorophytum arundinaceum etc. Aim was to determine whether treatment would improve sperm count and morphology of sperms. The mechanisms involved in the efficacy of these medicinal plants in sperm abnormalities are antioxidant, anti-inflammatory, anti-oedematous and venotonic activity as well as containing precursors for sperm production and increasing blood testosterone level. It was concluded that Addyzoa Tablet improves the density and motility of the sperms and thus is effective in the management of oligospermia and asthenospermia and no adverse effects were reported.

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