Review of research work done on Nishamalaki in type 2 Diabetes at institute of Teaching and Research in Ayurveda, Jamnagar
Abstract
Background: Nisha and Amalaki Churna are most commonly prescribed drugs used individually as well as in combination with other drugs in various diseases by Ayurvedic practitioners. The use of Nisha and Amalaki in Prameha is found in various classical texts, including Brihatrayees, Chakradatta, Bhaishajya Ratnavali among others. Diabetes is a major cause of health concern affecting around 10.5% of population. The most worrisome part is that its incidence is on the rise even in rural areas. Prameha (Madhumeha) wsr to Type 2 Diabetes) has adverse effects on many physiological processes and anatomical structures in the body (Saptadushya) and is considered as Mahagada. Aim of the present study was to compile such research works carried out on Nishamalaki at ITRA, Jamnagar and provide brief information about the studies. Material & methods: Total nine studies on Nishamalaki were screened from various PG departments of Institute of Teaching and Research in Ayurveda, Jamnagar. Results and Conclusion: All studies revealed that Nishamalaki reduces the clinical symptoms of Diabetes. The clinical efficacy has been evaluated in both type 1 (in modified form) and type 2 Diabetes. Satisfactory response with a decrease in the intensity of signs and symptoms was reported in all the studies. No adverse effects were reported in any of these studies.
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References
Agnivesha Charak Samhita of Acharya Charaka Chikitsa sthan Ch. 6 V.26, Chowkhamba Krishnadas Academy, Varanasi. Reprint edition 2020; p.266.
Sushruta, Sushruta Samhita Chikitsa Sthana Ch.11 V.8, Varanasi: Chowkhamba Orientalia; 2014.p.321.
Vriddha Vagbhata, Ashtanga Samgraha edited by Dr Shivprasad Sharma. Chikitsa Sthana Ch.14 V.6, Varanasi: Chowkhamba Sanskrit Series Office; 2019. p. 514.
Vagbhat, Ashtanga Hridaya, edited by Dr Brahmanand Tripathi. Uttara Sthana Ch.40 V.48, Delhi: Chaukhamba Sanskrit Pratishthan; 2017. p. 1212.
Chakrapanidatta, Chakradatta, edited by Bhishagratna Pandit Brahmashankar Mishra. Prameha Chikitsa V.21, Varanasi: Chowkhamba Sanskrit Series Office; 2012. p. 296.
Shri Govinda Dasa Sena, Bhaishajya Ratnavali, edited by Bhishagratna Shri Brahmashankar Mishra. Prameha chikitsa Ch.37V.6, Varanasi: Chaukhamba Prakashan; 2021.p.719.
Sharangdhar, Sharangdhar Samhita, Madhyam khanda Chp.1V.7, Varanasi: Chaukhamba Surbharati Prakashan, Reprint edition 2018; p138.
Hong Sun et al, IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045, Diabetes Research and Clinical Practice, Volume 183, 2022, 109119, ISSN 0168-8227, https://doi.org/10.1016/j.diabres.2021.109119. (https://www.sciencedirect.com/science/article/pii/S0168822721004782)
Agnivesha Charak Samhita of Acharya Charaka Chikitsa sthan Ch. 6 V.8, Chowkhamba Surbbharati Prakashan, Varanasi. Reprint edition 2018; p. 281.
Agnivesha Charak Samhita of Acharya Charaka Indriya sthan Ch. 9 V.8.9, Chowkhamba Sanskrit Series Office, Varanasi. Reprint edition seventh, 2002 p. 569.
Dalhanacharya commentator, Sushruta Samhita by Acharya Sushruta, edited by Vaidya Yadavaji Trikamji Acharaya, Nidanasthana, Ch.7V.27, Chaukhamba Krishanadas Academy, Varanasi. Reprint edition 2014; p.294.
Sharma S. H., Mishra S. K., Singh Gurdip. Madhumeha with reference to Medadushti and Kledadushti and effect of Haridra Amalaki. PG Dissertation submitted to Gujarat Ayurved University, Jamnagar, 1979.
Pandey S. K., Mishra S. K., Shukla V. D. Studies on phenomenon of Madhumeha in Ayurveda and its management with Ayurvedic formulation. PG Dissertation submitted to Gujarat Ayurved University, Jamnagar, 1982.
Katiyar V. C., Mishra S. K. Further studies on the phenomenon of Madhumeha and its management with Haridra Amalaki Churna and Devadarvyadi Ghanvati. PG Dissertation submitted to Gujarat Ayurved University, Jamnagar, 1984.
Upadhyay Tarun, Vyas H. A., Dwiedi R R, Vyas M K - Fundamental aspect of Pareeksha in Ayurveda wsr to Pratyaksha and its applied utility. PG Dissertation submitted to Gujarat Ayurved University, Jamnagar, 2015.
Bedarkar Prashant, Prajapati P.K. Role of drug combination wsr to effect of Nisha, Amalaki and Nisha Amalaki Yoga on glucose metabolism and antidiabetic effect. PhD Dissertation submitted to Gujarat Ayurved University, Jamnagar, 2017.
Sharma Vasundhara, Thakar A, Pandya D. H. Etiopathological study of Madhumeha (DM- II) and its management by Nisha-Amalaki Yoga - An Open labelled single arm clinical trial. PG Dissertation submitted to Gujarat Ayurved University, Jamnagar, 2018.
Purohit Palak, Patel K S, Kori V K, Nariya M - To evaluate the efficacy of modified Nisha Amalaki Yoga in Jataja Prameha W.S.R. to Juvenile Diabetes – an open label randomized controlled pharmaco-clinical study. PhD Dissertation submitted to Gujarat Ayurved University, Jamnagar, 2023.
Purohit P, Patel K. S., Nariya M. Evaluation of antihyperglycemic activity of modified Nisha Amalaki yoga in swiss albino mice. International journal of green pharmacy. July-Sept 2021;15(3):238-242.
Ingale Rajnandini, Dave A, Padh H - Efficacy of Kantkateryadi Vati and Nishamamalaki Vati in management of Madhumeha W.S.R. to Type 2 Diabetes – an open label randomized comparative clinical trial. PG Dissertation submitted to ITRA, Jamnagar, 2022.
Limbachiya Vedanshi, Bhinde S - Effect of Guduchyadi Yoga and Modified Nishamalaki Yoga as add on intervention in Jataja Prameha W.S.R. to Juvenile Diabetes – An open label randomized comparative clinical trial. PG Dissertation submitted to ITRA, Jamnagar, 2023.
Golechha M, Bhatia J, Ojha S, Arya DS, Hydroalcoholic extract of Emblica officinalis protects against kainic acid-induced status epilecticus in rats: evidence for an antioxidant, anti-inflammatory and neuroprotective intervention. Pharm Biol, Nov 2011, 49(11):1128-1136. Epub 2011 Jul 12. PMID: 21749189.
Cole GM, Teter B, Frautschy SA., Neuroprotective effects of curcumin. Adv Exp Med Biol., 2007; 595: 197-212.
Kosaraju J, Chinni S, Roy PD, Kannan E, Antony AS, Kumar MN., Neuroprotective effect of Tinospora cordifolia ethanol extract on 6-hydroxy dopamine induced Parkinsonism, Indian J Pharmacol, Mar-Apr 2014, 45(2): 176-80. PMID: 24171189; PMCID: PMC3987186.
Grover JK, Yadav S, Vats V. Medicinal plants of India with antidiabetic potential. J Ethnopharmacol 2002; 81:81-100.
Singh SS, Pandey SC, Srivastava S, Gupta VS, Patro B, Ghosh AC. Chemistry and biochemical properties of Tinospora cordifolia, Indian J Pharmacol 2003;35:83-91.
Patlak M. New weapons to combat an ancient disease: treating diabetes. FASEB J 2002 Dec;16(14):1853.
Kahn CR. Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes 1994 Aug;43(8):1066-1084.
Robertson RP. Antagonist: diabetes and insulin resistance–philosophy, science, and the multiplier hypothesis. J Lab Clin Med 1995 May;125(5):560- 564, discussion 565.
Fujioka K. Pathophysiology of type 2 diabetes and the role of incretin hormones and beta-cell dysfunction. JAAPA 2007; suppl 3-8.
Variya BC, Bakrania AK, Patel SS. Antidiabetic potential of gallic acid from Emblica officinalis: improved glucose transporters and insulin sensitivity through PPAR- and Akt signalling. Phytomedicine 2020 Jul 15; 73:152906.
Den Hartogh DJ, Gabriel A, Tsiani E. Antidiabetic properties of curcumin I: evidence from in vitro studies. Nutrients 2020; 12:118.
Arun, N., Nalini, N. Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats. Plant Foods Hum Nutr 57, 41–52 (2002). https://doi.org/10.1023/A:1013106527829
Panda V, Deshmukh A, Singh S, Shah T, Hingorani L. An Ayurvedic formulation of Emblica officinalis and Curcuma longa alleviates insulin resistance in diabetic rats: involvement of curcuminoids and polyphenolics. Journal of Ayurveda and Integrative Medicine 2021;12:512.
Tank R, Sharma N, Sharma I, Dixit VP. Antidiabetic activity of Curcuma longa (50%ethanolic extract) in alloxan-induced diabetic rats. Indian drugs 1989;27:587-9.
Dawane JS, Pandit VA, Deshpande SS, Mandpe AS. Preventive and Protective Effect of Nishamalaki in STZ Induced Diabetic Complications in Wistar Rats. J Clin Diagn Res. 2016 Jun;10(6):FF01-4. doi: 10.7860/JCDR/2016/17940.7912. Epub 2016 Jun 1. PMID: 27504308; PMCID: PMC4963668.
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