A Clinical Study to evaluate the therapeutic effect of Akulyaabdadi Kashaya in Madhumeha (Type-II Diabetes Mellitus)

Abstract

Introduction: In 2024 approximately 540 million adults (20-70 years) are living with diabetes as per data of IDF (international diabetes Federation). WHO states that diabetes will be 7^th leading cause of death by 2030. Ayurveda says Madhumeha is a variety of Vataja Parmeha where the patient passes the urine with sweetness and astringency. The main symptoms involved are Prabhoota Mootrata (excessive urination) and Avila-Mootrata (non-transparency of urine). The major cause of disease is sedentary lifestyle and indulgence in Kapha-Medakar Aahara along with Divaswapana (day sleeping), avoidance of any form of exercise, hence indicating Santarpanjanya origin of disease. Methods: Akulyaabdadi Kashaya, the first Kashaya mentioned in Pramehahara Kashayas if Sahasrayoga is taken for single blind clinical study on 30 patients and the efficacy is established post 30-days of treatment. Results: During the study, it was found that signs and symptoms like polyuria, turbidity in urine, polyphagia, excessive thirst, burning sensation and numbness in feet, weakness, excessive sweating and lassitude were significantly reduced and Akulyaabdadi Kashaya, the trial drug was found highly significant at 0.1% level with p- value <0.001 to improve the FBS, PPBS, urine glucose (FUS & PPUS) and  establishes it as a good treatment of Diabetes as a long term drug.