Effect of Draksha Samangadi Kashaya Ghan Vati in Adolescents with Psychological Distress - A Double Blind Randomized, Placebo Controlled Trial

Abstract

Aim of study: A double blind randomized, placebo-controlled trial was planned to evaluate the Clinical efficacy of Draksha Samangadi Kashaya Ghan Vati an Ayurveda multi-dimensional herb preparation in Adolescents suffering with Psychological Distress. The trial drug contains Draksha, Samanga, Gavakshi, Trayamana, Yashtimadhu, Chandana, Maricha, Pippali, Shunthi. All ingredients of the study drug possess anti-stress, anti-depression, anti-anxiety, nootropic and anti-oxidant properties. Materials and Methods: A total of 40 patients complected the trial, including male and female patients, were studied for suffering of Psychological Distress and were registered and divided into 2 groups (Group A, B,). In group A, patients were administered Draksha Samangadi Kashaya Ghan Vati, dose 500 mg/day twice a day for 2 months in children suffering from Psychological Distress. In group B, Placebo - Chocolate Coated Starch Tablets were administered to 20 patients at a dose of 500 mg/day. All the treated cases were assessed at each follow-up on the 14^th day, 28^th day, 42^nd day, and 56^th day, and post-follow-up was done after 1 month. The efficacy of drugs was assessed clinically and also based on Depression, anxiety and stress scale (DASS 42). Result: Group A consistently shows significant improvements across all three psychological conditions (Depression, Anxiety, and Stress) compared to Group B. Conclusion: Draksha Smangadi Kashaya Ghan Vati (Chocolate Coated) is effective in the management of Psychological Distress in Adolescents.