Recent developments in Integrated Medicine Approach in management of Type 1 and Type 2 Diabetes Mellitus: A Review
Abstract
Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder of growing global health concern characterized by insulin resistance and elevated blood sugar levels. While conventional medications offer significant benefits, they often come with adverse effects such as gastrointestinal disturbances and weight gain. Ayurveda, an ancient Indian system of medicine, provides a holistic alternative through the use of herbal and herbo-mineral formulations. Ayurveda and Yoga have emerged as complementary therapies with promising potential in diabetes management. This review discusses Ayurvedic formulations like Ayush- 82, PANHEAL, Dhanwantaram Kashayam, Shilajatvadi Lauha, and other standardized polyherbal therapies highlighting their efficacy in reducing blood sugar levels, improving insulin sensitivity, have demonstrated significant antioxidant, and lipid-lowering effects, as shown in various preclinical and clinical studies addressing complications related to T2DM. Also, this review explores the effectiveness of Ayurvedic formulations like GlucoCare and holistic modules that combine Panchakarma and Yoga practices. Clinical trials and studies demonstrate that these Ayurvedic interventions offer promising results in managing diabetes without the side effects associated with modern medications. Integrating these traditional therapies with modern treatments may offer a more holistic approach to managing diabetes.
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References
Panda AK. Efficacy of Ayurveda Formulation Ayush-82 (IME-9) in Newly Diagnosed Type 2 Diabetics: Retrospective Analysis of Individual Data. J Tradit Med Clin Naturopathy. 2017;6(4):250.
Shubha KS, Renni A, Mohan PMV. A Clinical Trial to Evaluate the Efficacy of Polyherbal Formulation (PANHEAL) in the Management of Type II Diabetes Mellitus. World J Pharm Res. 2019;8(13):994-1002.
Singh TR, Gupta LN, Kumar N, Kumar V. Anti-Diabetic Activity of Shilajatvadi Lauha, an Ayurvedic Traditional Herbo-Mineral Formulation. Int J Health Allied Sci. 2016;5(1):9-14.
Renganathan S, Srivastava A, Pillai RG. Dhanwantaram kashayam, an Ayurvedic polyherbal formulation, reduces oxidative radicals and reverts lipids profile towards normal in diabetic rats. Biochem Biophys Rep. 2020;22:100755.
Awasthi H, Nath R, Usman K, et al. Effects of a standardized Ayurvedic formulation on diabetes control in newly diagnosed Type-2 diabetics; a randomized active controlled clinical study. Complement Ther Med. 2015;23(6):555-561.
Sharma RK, Patki PS. Double-blind, placebo-controlled clinical evaluation of an Ayurvedic formulation (GlucoCare capsules) in non-insulin dependent diabetes mellitus. J Ayurveda Integr Med. 2010;1(1):45-50.
Vaibhavi B, Tripathi S, Patra S, Nagarathna R, Nagendra HR. Effect of holistic module of Yoga and Ayurvedic Panchakarma in Type 2 Diabetes Mellitus— A pilot study. Open J Endocr Metab Dis. 2013;3(1):90-98.
Datey P, Hankey A, Nagendra HR. Combined Ayurveda and Yoga Practices for Newly Diagnosed Type 2 Diabetes Mellitus: A Controlled Trial. Complement Med Res. 2017. DOI: 10.1159/000464441.
Bhardwaj D, Agnihotri VK, Pandya P. Clinical evaluation of an Ayurvedic formulation in the management of Type 2 Diabetes Mellitus. Dev Sanskriti Interdiscip Int J. 2012;1(1):50-64.
Chakraborty U, Das H. Antidiabetic and Antioxidant Activities of Cinnamomum tamala Leaf Extracts in STZ-Diabetic Rats. Glob J Biotechnol Biochem. 2010;5(1):12-18.
Sharma PV. Charaka Samhita. Varanasi: Chaukhambha Publications; 2001.
Gupta SS, Verma SC, Garg VP, Rai M. Anti-diabetic effects of Tinospora cordifolia. Indian J Med Res. 1967;55:733.
Sharma H, Chandola HM. Prameha in Ayurveda: correlation with obesity, metabolic syndrome, and diabetes mellitus. Part 2–management of Prameha. J Altern Complement Med. 2011 Jul;17(7):589-599. https://doi.org/10.1089/acm.2010.0397.
Thakral KK, Acharya Sushruta. Sushruta Samhita with Nibanda Sangraha commentary of Shri Dalhanacharya and Nyayachandrika Vyakhya by Sri Gayadasacharya, Vol 2 Chikitsasthana 11th chapter Pramehachikitsadhyaya Verse no.3, Choukhambha Orientalia, Varanasi; page no. 319.
Kumari S, Laxmikant SD, Sonika B, Khanal S. Efficacy of Integrated Ayurveda treatment protocol in type 2 Diabetes Mellitus: A case report. J Ayurveda Integr Med. 2022;13:100512.
Kumari S, Tubaki BR, Patil RS, Laxmikant SD. Reversal of type 2 diabetes mellitus through integrated Ayurveda dietary protocol: A case report. J Ayurveda Integr Med. 2024;15:100946.
Gowda S, Mohanty S, Saoji A, Nagarathna R. Integrated Yoga and Naturopathy module in management of Metabolic Syndrome: A case report. J Ayurveda Integr Med. 2017;8(1):45-48.
Ashtankar HS, Wasnik V, Jain SS. Lifestyle modification for prediabetes through Ayurvedic interventions – A case study. J Ayurveda Holist Med. 2024;12(4):65-70.
Shindhe PS, Kale AP, Killedar RS. Integrative management of diabetic foot ulcers – A case series. J Ayurveda Integr Med. 2023;14:100770.
Chandake S, Tubaki BR, Gonugade V, Sharma O. Efficacy of Tryushnadi Churna in Metabolic Syndrome with Obesity: A Randomized Double-Blind Controlled Clinical Trial. J Ayurveda Integr Med. 2024;15:100973. doi:10.1016/j.jaim.2024.100973.
Dongre P, Majumdar A. Network Pharmacology Analysis of Chandraprabha Vati: A New Hope for the Treatment of Metabolic Syndrome. J Ayurveda Integr Med. 2024;15:100902.
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