Pharmaceutical Standardization and Analytical Evaluation of different samples of Trayushnadi Gutika

Abstract

Introduction:
Ayurvedic pharmaceutics (Rasashastra) emphasizes the purification and formulation of mineral- and metal-based drugs to enhance therapeutic efficacy and bioavailability. Trayushnadi Gutika is a classical formulation requiring rigorous standardization for quality, safety, and efficacy. With increasing commercial demand and large-scale manufacturing, concerns arise regarding ingredient authenticity and pharmaceutical integrity. This study focuses on ensuring the standardization of Trayushnadi Gutika using traditional and modern analytical methods.

Methods:
Pharmaceutico - analytical study of both sample of Trayushnadi Gutika and its ingredients were carried out at Nagarjuna Laboratory, Department of Rasashastra and Bhaishajya Kalpana, Government Ayurvedic College, Patna, Bihar. Raw materials were authenticated based on Grahya Lakshana (acceptable characteristics) from classical texts. Pharmaceutical processing techniques were evaluated to ensure uniformity in formulation. Physicochemical analysis, including organoleptic characteristics, pH, moisture content, and other relevant parameters, was performed to assess the quality of the final product.

Results:
The analysis confirmed the authenticity and purity of raw materials used in Trayushnadi Gutika. Pharmaceutical processing evaluations indicated consistent formulation techniques across batches. Physicochemical assessments showed that the product met standard criteria for Ayurvedic formulations, ensuring therapeutic efficacy and stability.

Discussion:
This study highlights the importance of maintaining raw material authenticity and uniform manufacturing processes to ensure the efficacy of Ayurvedic formulations. By integrating traditional standardization techniques with modern analytical methods, Trayushnadi Gutika can be produced with consistent quality and reliability. Strengthening pharmaceutical standardization practices will enhance confidence in Ayurvedic therapeutics and promote its broader acceptance.