Turmeric - The Serendipitous Herb : A Review
Abstract
Phytotherapy, the use of herbal agents as medicines has become the focus of research in the recent years. This increased interest in the discovery of natural compounds is due to the various adverse effects of allopathic drugs and emergence of resistant strains of common pathogens. Turmeric or curcumin is one of the oldest spices that has been a vital part of Ayurvedic medicine, and has proven properties like anti-inflammatory, anti-oxidant, anti-microbial, antiseptic and antimutagenic properties making it a very viable and economical substitute. The objective of this article is to provide a brief overview of the plethora of research regarding the health benefits of curcumin and its uses in dentistry.
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Sharma A, Ahlawat B, Sharma S. Turmeric - Its Applications in Dentistry. J Adv Res Med 2016; 3(1): 27-30.
Nagpal M, S. Sood. Role of curcumin in systemic and oral health: An overview. J Nat Sci Biol Med 2013 Jan- Jun; 4 (1): 3-7.
Sarvesh D, Sarvesh V, Hemakeswani, Sharma S. Curcumin- a magical medicine: A comprehensive review. International ayurvedic medical journal, (issn:2320 5091). (February 2107) 5 (2).
Kuwatada JS, Raja M, Sood P. Turmeric- A boon to oral health. Int J Oral Care Res 2017; 5(4):338-341.
S.J. Hewlings, D S. Kalman Curcumin: A Review of Its’ Effects on Human Health Foods 2017, 6, 92; doi:10.3390/foods6100092.
Harshini A. K. Effectiveness of Turmeric in Dentistry-A Review Article. International Journal of Science and Research (IJSR). August 2017; 6(8).
Chattopadhyay.I, Biswas.K, Bandyopadhyay.U, Ranajit K.B. Turmeric and curcumin: Biological actions and medicinal applications. Current Science. 2004; 87(1): 44-53.
Jurenka J S. Anti-inflammatory Properties of Curcumin, a Major Constituent of Cur-cuma longa: A Review of Preclinical and Clinical Research. Alternative Medicine Review. Volume 14, Number 2 2009.
Anand P, Kunnumakkara A.B, Newman R.A, Aggarwal B.B. Bioavailability of curcumin: Problems and promises. Mol. Pharm. 2007, 4, 807–818.
Wahlstrom B, Blennow G. A study on the fate of curcumin in the rat. Acta Pharmacol Toxicol 1978; 43:86‑ 92.
Han H.K. The effects of black pepper on the intestinal absorption and hepatic metabolism of drugs. Expert Opin. Drug Metab. Toxicol. 2011, 7, 721–729.
Ravindranath V, Chandrasekhara N. Absorption and tissue distribution of curcumin in rats. Toxicology 1980; 16:259‑ 65.
Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas P.S. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998, 64, 353–356.
Basnet P, Skalko-Basnet N. Curcumin: An anti-inflammatory molecule from a curry spice on the path to cancer treatment. Molecules 2011, 16, 4567–4598.
Lao C.D, Ruffin M.T, Normolle D, Heath D.D, Murray SI, Bailey J.M. et al. Dose escalation of a curcuminoid formulation. BMC Complement. Altern. Med. 2006,6- 10.
Shihab Anwar A, Reshma V J, Abdulla Mufeed , Vadi Vazaghan, Johnson K Issac, Raj Gopal Singh Metha. Curcuminoids: The Panacea for Oral Pre-Cancer and Cancer Trivandrum Dental Journal-2014, Volume-5, Issue-1.
Ramirez-Boscá A, Soler A, Gutierrez MA. Antioxidant curcuma extracts decrease the blood lipid peroxide levels of human subjects. Age 1995; 18:167-9.
Kiso Y, Suzuki Y, Watanbe N, Oshima Y, Hikino H. Antihepatotoxic principles of Curcuma longa rhizomes. Planta Med 1983; 49:185-7.
Yuvraja Marudhappan, Mathews Jude, Sai Anusuya, Upama Sishian, Jibin Skaria, Dinoop Valsan. Antimicrobial Effect of Indian Medicinal Plants in Dental Caries. Archives of Dental and Medical Research Vol 1 Issue 3.
Vahdaty A, Pitt Ford T.R, Wilson, R.F. Efficacy of chlorhexidine in disinfecting dentinal tubules in vitro. Endod. Dent. Traumatol 1993; 9: 243-248.
Srivastava R, Puri V, Srimal RC, Dhawan BN. Effect of curcumin on platelet aggregation and vascular prostacyclin synthesis. Arzneimittelforschung 1986; 36:7157.
Mehta K, Pantazis P, McQueen T, Aggarwal BB. Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell line. Anticancer Drugs 1997; 8:470-81.
Menon LG, Kuttan R, Kuttan G. Anti-metastatic activity of curcumin and catechin. Cancer Lett 1999; 141:159-65.
Deodhar SD, Sethi R, Srimal RC. Preliminary studies on antirheumatic activity of curcumin (diferuloyl methane). Indian J Med Res 1980; 71:632-4.
Van Dau N, Ngoc Ham N, Huy Khac D. The effects of traditional drug, turmeric (Curcuma longa), and placebo on the healing of duodenal ulcer. Phytomedicine 1998; 5:29-34.
Lal B, Kapoor AK, Asthana OP, Agrawal PK, Prasad R, Kumar P, et al. Efficacy of curcumin in the management of chronic anterior uveitis. Phytotherapy Res 1999; 13:318-22.
Reddy AC, Lokesh BR. Effect of dietary turmeric (Curcuma longa) on iron-induced lipid peroxidation in the rat liver. Food Chem Toxicol 1994; 32:279-83.
Chaturvedi TP. Uses of turmeric in dentistry: An update. Indian J Dent Res 2009; 20:107‑ 9. 29. Snow JM. Curcuma longa L. (Zingiberaceae). Protocol J Botan Med 1995; 1:43-6.
Arora RB, Kapoor V, Basu N, Jain AP. Anti-inflammatory studies on Curcuma longa (turmeric). Indian J Med Res 1971; 59:1289-95.
Srivastava R, Dikshit M, Srimal RC, Dhawan BN. Antithrombotic effect of curcumin. Thromb Res 1985; 40:413-7.
Devaraj S D, Neelakantan P. Curcumin- Pharmacological actions and its role in dentistry. Asian J Pharmaceut Res Health Care Volume 6 Issue 1.
Mathur V, Tijare M, Desai A, Gupta S, Kallianpur S. Curcumin – Oral cure from the Indian curry. Inter. J. of Pharmacotherapy; 4(3), 2014, 137-140.
Sahebkar A, Serbanc M.C, Ursoniuc S, Banach M. Effect of curcuminoids on oxidative stress: A systematic review and meta-analysis of randomized controlled trials. J. Funct. Foods 2015, 18, 898–909.
Panahi Y, Alishiri G.H, Parvin S, Sahebkar A. Mitigation of systemic oxidative stress by curcuminoids in osteoarthritis: Results of a randomized controlled trial. J. Diet. Suppl. 2016, 13, 209–220.
Menon V.P, Sudheer A.R. Antioxidant and anti-inflammatory properties of curcumin. Adv. Exp. Med. Biol.2007, 595, 105– 125.
Lin Y.G, Kunnumakkara AB, Nair A, Merritt WM, Han, LY, Armaiz-Pena GN, et al. Curcumin inhibits tumor growth and ngiogenesis in ovarian carcinoma by targeting the nuclear factor-ķB pathway. Clin. Cancer Res. 2007,13, 3423–3430.
Marchiani A, Rozzo C, Fadda A, Delogu G, Ruzza, P. Curcumin and curcumin-like molecules: From spice to drugs. Curr. Med. Chem. 2014, 21, 204–222.
Panahi Y, Hosseini MS, Khalili N, Naimi E, Simental-Mendia LE, Majeed M, et al. Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A posthoc analysis of a randomized controlled trial. Biomed. Pharmacother. 2016, 82, 578–582.
Ammon HP, Safayhi H, Mack T, Sabieraj J. Mechanism of antiinflammatory actions of curcumin and boswellic acids. J Ethnopharmacol 1993; 38:113-9.
Grover H S, Deswal H, Bhardwaj A. Curcumin: A medicinal plant and its effects in medicine and dentistry. International Journal of Contemporary Dental and Medical Reviews (2015), Article ID 090115.
Hanif R, Qiao L, Shiff SJ, Rigas B. Curcumin, a natural plant phenolic food additive, inhibits cell proliferation and induces cell cycle change in colon adenocarcinoma cell lines by a prostaglandin‑ independent pathway. J Lab Clin Med 1997; 130:576‑ 84.
Namratha K, Shenai P, Chatra L, Rao P K, Veena K M, Prabhu R V. Antioxidant and Anticancer effects of curcumin – A Review. Journal of Contemporary Medicine 2013;3(2): 136- 143.
Mohammed NA. Evalution of antimicrobial activity of curcumin against two oral bacteria. J Acis S 2015; 3(2-1):18- 21.
Rasmussen HB, Christensen SB, Kvist LP, Karazami A. A simple and efficient separation of the curcumins, the antiprotozoal constituents of Curcuma longa. Planta Med 2000; 66:396‑ 8.
Deshpande UR, Gadre SG, Raste AS. Protective effect of turmeric (Curcuma longa L.) extract on carbon tetrachloride‑induced liver damage in rats. Indian J Exp Biol 1998; 36:573‑ 7.
Park EJ, Jeon CH, Ko G, Kim J, Sohn DH. Protective effect of curcumin in rat liver injury induced by carbon tetrachloride. J Pharm Pharmacol 2000; 52:437‑ 40.
Donatus IA, Sardjoko, Vermeulen NP. Cytotoxic and cytoprotective activities of curcumin. Effects on paracetamol‑ induced cytotoxicity, lipid peroxidation and glutathione depletion in rat hepatocytes. Biochem Pharmacol 1990; 39:1869‑ 75.
Soni KB, Rajan A, Kuttan R. Reversal of aflatoxin induced liver damage by turmeric and curcumin. Cancer Lett 1992; 66:115‑ 21.
Ramprasad C, Sirsi M. Curcuma longa and bile secretion. Quantitative changes in the bile constituents induced by sodium curcuminate. J Sci Ind Res 1957; 16:108‑ 10.
PDR for herbal medicines. 2nd Edn. Montvale. NJ: Medical Economics Company, 2000: 776.
Lakshmi T, Jyotsna Srinath. Application of spices in dentistry – A literature review. Int J Drug Dev & Res 2014:1-9.
Bharat B. Aggarwal, Sundaram C, Malani N, Ichikawa H. Curcumin: The Indian solid gold. Adv Exp Med Biol.2007; 595: 1-75.
Subasree S, Murthykumar K, Sripradha S, Naveed N. Effects of turmeric on oral health: An overview. Int J Pharm Sci Health Care 2014; 2:6-14.
Niyomploy P, Thunyakitpisal P, Karchanatat A, Sangvanich P. Cell proliferative effect of polyxyloses extracted from the rhizomes of wild turmeric- Curcuma aromatic. Pharmaceutical Biology 2010; 48:932-7.
Soni UN, Baheti MJ, Toshniwal NG. Turmeric in Dentistry – The Hidden Potential. J Pharm Biomed Sci 2015; 05(01): 84- 89.
Suhag A, Dixit J, Dhan P. Role of curcumin as a subgingival irrigant: A pilot study. Periodontal Pract Today 2007; 2: 115- 21.
Gottumukkala SN, Koneru S, Mannem S, Mandalapu N. Effectiveness of subgingival irrigation of an indigenous 1 curcumin solution on clinical and microbiological parameters in chronic periodontitis patients: A pilot randomised clinical trial. Contemp Clin Dent 2013 Apr: 4(2): 186-191.
Waghmare PF, Chaudhary AU, Karhadkar VM, Jamkhande AS. Comparative evaluation of turmeric and chlorhexidine gluconate mouthwash in prevention of plaque formation and gingivitis: A clinical and microbiological study. J Contemp Dent Pract 2011; 12:221‑ 2.
Behal R, Mali AM, Galida SP, Paradkar AR. Evaluation of local drug delivery system containing 2% whole turmeric gel as an adjunct to scaling and root planning in chronic periodontitis: A clinical and microbiological study. J Indian Soc Periodontol 2011; 15(1): 35-38.
Deepa DA, Anita B, Sreelatha KT. Comparative study of the efficacy of curcumin and turmeric oil as chemoprotective agents in oral submucous fibrosis: A clinical and histopathological evaluation. JIAOMR 2010; 22:88‑ 92.
Manifar S, Obwaller A, Gharehgozloo A, Boorboor Shirazi Kordi HR. Curcumin gel in treatment of minor aphthous ulcer: A randomised placebo-controlled trial. J Med Plants 2012; 11(41); 40-45.
Deshmukh RA, Bagewadi AS. Comparison of effectiveness of curcumin with triamcinolone acetonide in the gel form in treatment of minor recurrent aphthous stomatitis: A randomised clinical trial. Int J Pharm Investig 2014 Jul; 4(3); 138-141.
Jaswal R, Dhawan S, Grover V, Malhotra R. Comparative evaluation of single application of 2 % whole turmeric gel versus 1% chlorhexidine gel in chronic periodontitis patients: a pilot study. J Indian Soc Periodontal 2014; 18(5): 575-580.
Anitha V, Rajesh P, Shamugham M, Priya BM, Prabhu S, Shivakumar V. Comparative evaluation of natural curcumin and synthetic chlorhexidine in the management of chronic periodontitis as local drug delivery: a clinical and microbiological study. Indian J Dent Res 2015 Jan-Feb; 26 (1): 53-56.
P.A. Lone, SW Ahmed, Vivek Prasad, Bashir Ahmed. Role of turmeric in management of alveolar osteitis (dry socket): A randomised clinical study. Journal of Oral Biology and Craniofacial Research 8 (2018);44–42.
Habiboallah G, Nasroallah S, Mahdi Z. Histopathological evaluation of Curcuma long-ghee formulation and hyaluronic acid on gingival healing in dog. J Ethanopharmacol 2008; 120(3): 335-41.
M. Ranjinkanth, A Ravi Prakash et al. Efficacy of specific plant products on microorganisms causing dental caries. JCDR 2016 Dec; 10(12): ZM01-ZM03.
Microbiology. Grossman’s Endodontic Practise,13th edition. Wolters Kluwer, New Delhi, 2014 pp 47-48.
Neelakantan P, Subbarao C, Sharma S, Subbarao CV, GarciaGodoy F, Gutmann JL. Effectiveness of curcumin against Enterococcus faecalis biofilm. Acta Odontologica Scandinavica, 2013;71:1453-7.
Jay Chamele, Chetan Bhat. Efficacy of turmeric extract as an intracanal medicament in deciduous teeth against Enterococcus faecalis: An in vitro study. Int.J.Curr.Microbiol.App.Sci (2014) 3(9) 17-25
Prasanna N, Chandana S, Chandragiri V. Analysis of antibacterial activity of curcumin against Enterococcus faecalis. Int. j. curr. res.rev 2011; 3(4): 68 77.
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