A toxicological review of Dhatura
Abstract
Dhatura is mentioned under the group of Sthavara Vanaspatic Visha, in different Ayurvedic text books it is also referred as deliriant poison. Dhatura is a genus of nine species of flowering plants which are poisonous in nature. On scrutinizing, the seeds and flowers of Dhatura plant contain alkaloids such as Scopolamine, Hyoscyamine and atropine which are highly toxic but found therapeutically essential as well. The poisonous substance (alkaloids) possess anticholinergic effects such as tachycardia, hyperthermia, mydriases etc., which can be resolve by administration of physostigmine as an antidote. Medico legally it has been found that the drug is being used as stupefying agent mixed in Prasad by the robbers for robbery, kidnapping, and also as homicidal as well as suicidal.
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