Granulomatous Lobular Mastitis - Ayurvedic understanding and management - A Case Report
Abstract
Granulomatous lobular mastitis (GLM) is a type of rare benign inflammatory disorder of breast with unknown aetiology. GLM cases presents with breast mass, abscess, inflammation and recurrent mammary duct fistula and necessitates histopathology for an accurate diagnosis. Management of GLM consists of surgical, medical or combined treatment but often results in recurrence, poor wound healing & chronic sinus formation. As per Ayurvedic literature, clinical features of GLM can be considered to different stages of Stana Vidradhi (breast abscess). There are very few reported Ayurveda case studies available in indexed journals in management of GLM. In the present case report a 23-year-old uniparous woman diagnosed with GLM presented with recurrent breast abscess and multiple sinuses over right breast. She was not responsive to steroidal treatment, and required recurrent abscess drainage and sinus tract removal. The condition with presentation of different stages of Sopha (inflammation), Vidhradi (abscess) & Nadi Vrana (sinus), was treated simultaneously with Sophahara and Vranahara medicines internally as well as Kshalana Ropana medicines externally. Multiple hard lumps were treated with application of Sopha-Granthihara medicines. Symptoms completely resolved in 3 months and she was followed-up without medicines for another 2 years during which period no recurrence was observed. Managing such incurable, highly recurrent conditions with Ayurvedic medicines proves to be promising.
Downloads
References
Tse GM, Poon CS, Ramachandram K, Ma TK, Pang LM, Chu WC, Tang AP, Cheung H. Granulomatous mastitis: a clinicopathological review of 26 cases. Pathology. 2004;36:254–257.
Seo H.R., Na K.Y., Yim H.E. Differential diagnosis in idiopathic granulomatous mastitis and tuberculous mastitis. J Breast Cancer. 2012;15:111–118.
Bouton ME, Jayaram L, O'Neill PJ, Hsu CH, Komenaka IK. Management of idiopathic granulomatous mastitis with observation. Am J Surg. 2015;210:258–262.
Altintoprak F., Kivilcim T., Ozkan O.V. Aetiology of idiopathic granulomatous mastitis. World J Clin Cases. 2014;2:852–858.
Balakrishnan M, K S. Post-operative Ayurvedic management of non-healing idiopathic granulomatous mastitis - A case report. J Ayurveda Integr Med. 2021 Oct-Dec;12(4):710-714. doi: 10.1016/j.jaim.2021.06. 023. Epub 2021 Nov 12. PMID: 34776324; PMCID: PMC8642695.
Mahlab-Guri K, Asher I, Allweis T, Diment J, Sthoeger ZM, Mavor E. Granulomatous lobular mastitis. Isr Med Assoc J. 2015;17:476–480.
Liu L, Zhou F, Zhang X, Liu S, Liu L, Xiang Y, Guo M, Yu L, Wang F, Ma Z, Li L, Gao D, Zhang Q, Fu Q, Yu Z. Granulomatous Lobular Mastitis: Antituberculous Treatment and Outcome in 22 Patients. Breast Care (Basel). 2018 Oct;13(5):359-363. doi: 10.1159/000487935. Epub 2018 Jul 5. PMID: 30498422; PMCID: PMC6257198.
Susruta, Susruta Samhita with the Nibandhasangraha Commentary of Shri Dalhanacharya and the Nyayachandrika Panjika of Shri Gayadasacharya on Nidanasthana, edited by Vaidya Yadavji Trikamji Acharya, Nidana Sthana 10/16-17, Chaukhamba Subharati Prakshan, Varanasi, Edition 2018.
Susruta, Susruta Samhita with the Nibandhasangraha Commentary of Shri Dalhanacharya and the Nyayachandrika Panjika of Shri Gayadasacharya on Nidanasthana, edited by Vaidya Yadavji Trikamji Acharya, Nidana Sthana 10/26, Chaukhamba Subharati Prakshan, Varanasi, Edition 2018.
Susruta, Susruta Samhita with the Nibandhasangraha Commentary of Shri Dalhanacharya and the Nyayachandrika Panjika of Shri Gayadasacharya on Nidanasthana, edited by Vaidya Yadavji Trikamji Acharya, Sutra Sthana 17/12, Chaukhamba Subharati Prakshan, Varanasi, Edition 2018
Susruta, Susruta Samhita with the Nibandhasangraha Commentary of Shri Dalhanacharya and the Nyayachandrika Panjika of Shri Gayadasacharya on Nidanasthana, edited by Vaidya Yadavji Trikamji Acharya, Nidana Sthana 10/9, Chaukhamba Subharati Prakshan, Varanasi, Edition 2018.
Srikantha Murthy KR, editor. Ashtanga Hridaya of Vagbhata, Chikitsasthana; Vidradhi vridhi chikitsa: Chapter 13, Verse 1. 6th ed. Varanasi: Chaukhamba Krishnadas Academy; 2012. p. 391
Susruta, Susruta Samhita with the Nibandhasangraha Commentary of Shri Dalhanacharya and the Nyayachandrika Panjika of Shri Gayadasacharya on Sutrasthana, edited by Vaidya Yadavji Trikamji Acharya, Sutra Sthana 17/17-18, Chaukhamba Subharati Prakshan, Varanasi, Edition 2018.
Shetty, P.M., Kedukodi, P., & Kamath, S. (2020). Gandhaka Rasayana: Possible Role as a Modulator of Fibroblast Cell Function in Wound Healing. International Journal of Health Sciences and Research, 10, 36-45.
Srikantha Murthy KR, editor. Ashtanga Hridaya of Vagbhata, Chikitsasthana; Vidradhi vridhi chikitsa: Chapter 13, Verse 11-13. 6th ed. Varanasi: Chaukhamba Krishnadas Academy; 2012. p. 393
Srikantha Murthy KR, editor. Ashtanga Hridaya of Vagbhata, Uttarasthana; Bagandhara Pratisheda: Chapter 28, Verse 40. 6th ed. Varanasi: Chaukhamba Krishnadas Academy; 2012. p. 272
Sruthi, C.V., & Sindhu, A. A Preliminary Study on the Phytochemicals and Antioxidant Potential Of Gulgulupanchapala Choorna used in the Management of Fistula - in - Ano. IJRAP. 2013; (4):519-521
Kumar MS, Kirubanandan S, Sripriya R, Sehgal PK. Triphala promotes healing of infected full-thickness dermal wound. J Surg Res. 2008 Jan;144(1):94-101. doi: 10.1016/j.jss.2007.02.049. Epub 2007 Jul 27. PMID: 17662304
Srikantha Murthy KR, editor. Ashtanga Hridaya of Vagbhata,Uttarasthana; Vrana Pratisheda: Chapter 25, Verse 67. 6th ed. Varanasi: Chaukhamba Krishnadas Academy; 2012. p. 246
Prasad, Anjali & Rishu, Sharma & Nisha, Sharma & B, Prasad & Sachin, Agrawal. (2016). Management of Dushta Vrana by Jatyadi Ghrita. IJAAR. 2016. 695-975.
Srikantha Murthy KR, editor. Ashtanga Hridaya of Vagbhata, Chikitsasthana; Vata vyadhi chikitsa: Chapter 21, Verse 58-61. 6th ed. Varanasi: Chaukhamba Krishnadas Academy; 2012. p.508
Patil, Babasaheb & Sonaje, Manoj. (2013). Role of Guggulutiktaka Ghrita in the management of osteoarthritis W.S.R. to knee joint. International Journal of Research in Ayurveda and Pharmacy. 4. 71-73. 10.7897/2277-4343.04128.
Mohan, Mohind & Abhimannue, Anu & Kumar, Prakash. (2021). Modulation of proinflammatory cytokines and enzymes by polyherbal formulation Guggulutiktaka ghritam. Journal of Ayurveda and integrative medicine. 12. 13-19. 10.1016/j.jaim.2018.05.007.
Bhat, Rama & Prajna, P & Kumar, V & Hegde, M & Singh, L. (2011). Antimicrobial properties of leaves of Calycopteris floribunda Lam. Journal of Medicinal Plants Research.5.
Acharya Y T. Caraka Samhita of Agnivesa, Sharira Sthana, Chapter-8/24, Ayurveda Dipika commentary by chakrapani, Chaukhamba Surbharati Prakashan, New Delhi, 2013
Vyas, Kruti & Barve, Mayur & Ravishankar, Basavaiah & Prajapati, Pradeep & Ruknuddin, Galib. (2015). Wound Healing Activity of Shatadhauta Ghrita: An Experimental Evaluation. Inventi Rapid: Ethnopharmacology Vol. 2015, Issue 3. 1-5.
G. Prabhakar Rao, editor. Bhaisajya Ratnavali of Kaviraj Shri Govinda Das Sen, Vol II; Udarda Seetapita Kota Chikitsa prakaran: Chapter 55, Verse 13-17. 1st ed. Varanasi: Chaukhambha Orientalia; 2014.p. 346
Srikantha Murthy KR, editor. Ashtanga Hridaya of Vagbhata,Sutrasthana;Sodhanadi gana samgraha: Chapter 15, Verse 21-22. 6th ed. Varanasi: Chaukhamba Krishnadas Academy; 2012. p. 203
Ram Nivas Sharma, editor. Sahasrayoga; Churna prakaran, 3rd ed. New Delhi: Chaukhambha Sanskrit Pratishtan;2012.
Ram Nivas Sharma, editor. Sahasrayoga; Gutika prakaran, 3rd ed. New Delhi: Chaukhambha Sanskrit Pratishtan;2012.p. 245
Copyright (c) 2023 Prajitha P.K., Nikhila K. P.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Journal of Ayurveda and Integrated Medical Sciences (JAIMS) retains the copyright of the contents of this journal but grant the readers the right to use the contents with terms and conditions under a creative common attribution licenses 4 of Attribution, Share Alike and Non-commercial type (CC BY-NC-SA) that allows copy, distribute, display, and perform the work and make derivative works based on it only for non-commercial purposes.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.