In Vivo Evaluation of Sothaghna Karma (Anti-Inflammatory Activity) of Bilwa (Aegle marmelos Corr.) Moola Twak and Patra - A Comparative Study

Abstract

One of the characteristics of living tissues is its ability to react to injury, there occurs Inflammation. Inflammation is identified as a symptom according to modern science, whereas in Ayurveda, it is correlated to Sotha, considered as a separate clinical condition, mentioning its Lakshana’s (Signs & Symptoms) and Upadrava (Complications) in relation with several ailments. Since ancient times, human societies have searched several Sotha Hara Dravyas. In the literature of Ayurveda, Bilwa (Aegle marmelos Corr.) is mentioned as one of the Shwayathuhara / Sotha Hara Dravyas among Charaka Daseimani Ganas. The present study is taken up to evaluate the comparative Sothaghna Karma (Anti-inflammatory activity) of Bilwa Moola Twak and Patra of different solvent extracts to standard drug Indomethacin suspension in four different groups of albino rats. On statistical analysis of data Trial drug A when compared with Standard drug, the resultant ‘t’ value showed insignificant difference at P > 0.05. Trial drug B when compared with Standard drug, the resultant ‘t’ value showed insignificant difference at P > 0.05. Both trial drugs and standard drug showed similar results, where as Bilwa Moola Twak Kashaya and Patra Swarasa has significant action in inhibiting inflammation. Trial drugs in 2^nd and 3^rd groups showed insignificant difference, having similar anti q-inflammatory action. Based on the observations made and results obtained statistically, the Bilwa Moola Twak can be replaced with Patra for inhibiting Sotha.