An experimental study to evaluate the concept of Trividha Atisevana Varjya Dravya w.s.r. to Lavana

  • Dr. Shilpa Nimbal Post Graduate Scholar, Dept of Samhita and Siddhanta, BLDEA’S AVS Ayurveda Mahavidyalaya, Vijayapur, Karnataka, India.
  • Dr. Umapati C. Baragi Associate Professor & HOD, Dept of Samhita and Siddhanta, Faculty of Ayurved, Main Campus, Uttarakhand Ayurved University, Dehradun, Uttarakhand, INDIA.
  • Dr. Kashinath Hadimur Associate Professor, Dept. of Rasa Shastra & Bhaishajya Kalpana, BLDEA’S AVS Ayurveda Mahavidyalaya, Vijayapur,
  • Dr. Jyothi Alias Jyostna Assistant Professor, Dept of Samhita and Siddhanta, BLDEA’S AVS Ayurveda Mahavidyalaya, Vijayapur, INDIA.
Keywords: Acute, Sub-acute, Toxicity, Lavana, Salt

Abstract

Background: Lavana is used as medicine as well as Ahara since ancient times. In Caraka Samhita it has been mentioned that three Dravyas viz. Pippali, Kshara (alkali) and Lavana (salt) can be used as emergency medicine, but they should not be consumed in excess (Ati Upayunjita). Hence in the present study Lavana has been evaluated in experimental animals in two different phases’ viz. Acute administration at graded doses as part of acute toxicity study and Sub-Acute administration at fixed dose level, as part of toxic Sub-Acute toxicity study, to assess the possible adverse effects. Materials & Methods: Wistar strain albino rats of either sex weighing between 150 - 200g. body weights were used, The experiment was carried out in accordance with the direction of the Institutional animal ethics committee (IAEC) after obtaining its permission (Approval number IAEC – 138/k/2018). Results: Results were drawn based on histopathological reports and biochemical reports of each group of toxicity study. Acute toxicity study has been carried out in albino rats receiving the 2 dose level maximum at up to 10 times higher (855mg/kg) then the therapeutic equivalent dose (427.5mg/kg). In Sub-Chronic toxicity: dose given was five times higher than therapeutic equivalent dose and ten times the equivalent to human therapeutic dose for duration of 30 days. Discussion: Toxicity is not found in Acute study and in Sub-Acute study moderate to high toxicity is found.

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References

Acharya Vidhyadar Shukla, Charaka Samhita, Vimanastana, 1st chapter, Rasavimaniya Adhyaya, Chaukamba Publications. Varanasi. Pg .no 552 ,

Ayush gruidelines for Toxicity / safety evaluation of Ayurveda and Siddha plant drugs, available from www.ccras.nic.in.

Paget GE and Barnes JM. Evaluation of drug activities. In: Lawrence DR and Bacharach AL, editors, Pharmacometrics. New York: Academic Press; 1964.p.161.
CITATION
DOI: 10.21760/jaims.v4i04.662
Published: 2019-08-31
How to Cite
Dr. Shilpa Nimbal, Dr. Umapati C. Baragi, Dr. Kashinath Hadimur, & Dr. Jyothi Alias Jyostna. (2019). An experimental study to evaluate the concept of Trividha Atisevana Varjya Dravya w.s.r. to Lavana. Journal of Ayurveda and Integrated Medical Sciences, 4(04), 191-198. https://doi.org/10.21760/jaims.v4i04.662
Section
Original Article