Role of Panchamruta Rasa (Panchadasha) as a immunomodulator w.s.r. Rasayana : A Review
Abstract
In Ayurveda, text immunity had been described by Chakrapani in terms of Vyadhikshamatva and it is termed as a state of equilibrium of Oja, Bala, Prakrit Kapha. The modulation of immune response by using Ayurvedic herbal medication as a possible therapeutic measure has now become a subject of scientific investigation. Immunomodulators can be defining as substance which can affect any function of the immune system including both innate and adaptive immunity. In Ayurveda, this concept of immunomodulation correlated with Rasayana. Rasayana acts in the body at three levels i.e. Rasa, Agni, Strotas. The present review is undertaken for screening minerals & herbs (ingredients) of Panchamruta Rasa (Panchadasha) to evaluate their immunomodulatory properties and establish the correlation between Rasayana and immunomodulatory effect. Critical review of minerals & herbs to show immunomodulatory property is compiled from various Ayurvedic texts as well as from multiple articles on the internet to justify their immunomodulatory property on the basis of data collected. This also shows their potential to act as antioxidant, anti-stress, anti-inflammatory, anti-bacterial, vaccine adjuvant, or immunity against diseases property.
Downloads
References
http://nordan.daynal.org/wiki/index.php?title=Immunity.
Vijaykumar S. Kotrannavar, Nadeem Tamboli. An in-Vitro Evaluation of Immunomodulator Effect of Shataputa Abhraka Bhasma.Indian Journal of Ancient Medicine and Yoga. October December 2017; Volume 10(4).p.137
Singune S.,Vaghela J.S.,Sisodia S.S. Review of Immunomodulation and Immunomodulatory activity of some medicinal plant.EJBPS 2018;Vol 5,Issue 8.p.165.
Patel K. A review on herbal immunoadjuvant. International Journal of Pharm. & Life;March 2012;Vol.3, Issue 3:,1568- 1576.p.1569
Kumar Soni M., Sharma O. Importance of Rasayan in Immunity(Vyadhikshamatva).WJPMR. February 2018; Vol 4(3).p.197
Agnivesha. Charaka Samhita. Edited by Shastri R. Varansi: Chaukhamba Bharati Academy.2011; Chikitsasthana Ch-1/8; p.5
Kumari M.,Devi D. Role if Rasayana as Immunomodulator in Diseases.International Ayurvedic Medical Journal:Vol 3;Issue 8;August 2015.p.2538
Sharma H. RasaYogSagar. Varanasi:Chaukamba Krishnadas Prakashana. Sanskaran2010;Part-2;Sholka(69)297-301; p.22- 23.
Sembulingam K., Sembulingam P. Essentials of Medical Physiology: New Delhi; Jaypee Brothers Medical Publishers (P) Ltd;Sixth edition 2012,Ch-17.p.107-116.
Joshi V., Joshi M. Vyadhikshamatva: Conceptual and Holistic Approach to Immunity in Ayurveda. Int J Ayu Pharm Chem 2019,Vol 11,Issue .p.270.
Agnivesha, Charaka Samhita with Ayurved Deepika Commentary of Chakrapanidatta, edited byYadavji T. Chaukhamba Sanskrit Sansthan,Varanasi, Reprint, Sutrasthana,Chakrapani Commentary,2014;28/7,p.178.
Agnivesha, Charaka Samhita with Ayurved Deepika Commentary of Chakrapanidatta, edited byYadavji T. Chaukhamba Sanskrit Sansthan, Varanasi, Reprint, Sutrasthana,ChakrapaniCommentary,2014;28/7,p.178.
Agnivesha. Charak Samhita with Chakrapani Virchit Ayurved Dipikavyakhya; edited by Joshi Y.G.,Part -1,Ch-17/75.p.239.
Agnivesha. Charak Samhita with Chakrapani Virchit Ayurved Dipikavyakhya; edited by Joshi Y.G.,Part -1, Ch-17/74.p.239.
Agnivesha. Charak Samhita with Chakrapani Virchit Ayurved Dipikavyakhya; edited by Joshi Y.G.,Part -1, Ch-30/74.p.406.
Maharshi Sushruta. Sartha Sushruta Samhita. edited by Borkar D.B. ,Pune: Rajesh Prakashana; Sustrastana Ch- 15/24; p.58
Singune S., Vaghela J.S., Sisodia S.S. Review of Immunomodulation and Immunomodulatory activity of some medicinal plant. EJBPS 2018;Vol 5,Issue 8.p.165.
Martinez A., Mattila R.,Gomez-Font R., Immunomodulatory drugs: Oral and systemic adverse effects; Med Oral Ptol Oral Cir Bucal.2014 Jan 1;19(1):e24-31.
Tripathi J.S.,Singi R.H. The concept and Practice of Immunomodulation in Ayurveda and the role of Rasayanas as Immunomodulators. Ancient Science of life; Vol No.XIX(1&2)July,August,September,October 99.
Agnivesha.Charak Samhita with Hindi commentary Shukla V.Tripathi ,R.edited by Kale V.,Delhi:Chaukhamba Sanskrit Pratisthan ,2014,Part-2,Ch-1/1/8.p.5
Maharshi Sushruta. Sartha Sushruta Samhita. edited by Borkar D.B. ,Pune: Rajesh Prakashana; Sustrastana Ch- 27/3; p.508
Vagbhat. Sartha Vagbhat with Marathi commentary,edited by Garde G.K., Varanasi: Chaukhamba Subharati Prakashana, 2011, Uttartantra, Ch-39/2,p.475.
Sharangadharacharya. Sharangadhara samhita. edited by Tripathi B, Varanasi: Chaukhamba Surbharti Prakashan; edition 2008, Purva Khanda Ch-4/13;p.48.
Agnivesha.Charak Samhita with Hindi commentary Shukla V.Tripathi ,R.edited by Kale V.,Delhi:Chaukhamba Sanskrit Pratisthan ,2014,Chikitsasthan;Part-2,Ch-1/1/16.p.7.
Agnivesha.Charak Samhita with Hindi commentary Shukla V.Tripathi ,R.edited by Kale V.,Delhi:Chaukhamba Sanskrit Pratisthan ,2014,Chikitsasthan;Part-2,Ch-1/1/30-35.p.41
Maharshi Sushruta. Sartha Sushruta Samhita. edited by Borkar D.B. ,Pune: Rajesh Prakashana; Sustrastana Ch- 27/3; p.508
Kumari M.,Devi D. Role if Rasayana as Immunomodulator in Diseases.International Ayurvedic Medical Journal:Vol 3;Issue 8;August 2015.p.2538
Chulet R., Pradhan P. A review on Rasayana, PHCOG REV. Vol 3, Issue 6, 229-234 ,p.230.
Bhava prakasha, Bhavaprakash Nighantu, edited by Chunekar KC., Pandey GS., Varanasi :Choukhamba Bharati Academy, 2010,Part-1;p-613.
Sharma S. Rasatarangini. edited by Shastri P.K,Delhi: Motilal Banarasidas; Reprint 2004.Ch- 8/36-37.p.185
Sharma S. Rasatarangini. edited by Shastri P.K,Delhi: Motilal Banarasidas; Reprint 2004.Ch- 10/72-73.p.234
Sharma S. Rasatarangini. edited by Shastri P.K,Delhi: Motilal Banarasidas; Ch- 20/83p.371
Sharma S. Rasatarangini. edited by Shastri P.K,Delhi: Motilal Banarasidas; Reprint 2004.Ch- 18/39-42.p.443
Sharma S. Rasatarangini. edited by Shastri P.K,Delhi: Motilal Banarasidas; Reprint 2004.Ch- 19/43.p.464
Vaishya S. Rasayansara: Varanasi;Shyamsundar Rasayanshala Prakashana Gayghat;Sanskaran 5; Cha.55-60;p.59
Maharshi Sushruta. Sartha Sushruta Samhita. edited by Borkar D.B. ,Pune: Rajesh Prakashana; Sustrastana Ch- 45/49; p.192
Ayurvedic Pharmacopoeia of India Part-1, Vol-1, 1st edition, Delhi: The Controller of Publications; 2008; Vol-1, Ch; p.1.
Ayurvedic Pharmacopoeia of India Part-1, Vol-1, 1st edition, Delhi: The Controller of Publications; 2008; Vol-1, p.15.
Ayurvedic Pharmacopoeia of India Part-1, Vol-1, 1st edition, Delhi: The Controller of Publications; 2008; Vol-4, p.108
Ayurvedic Pharmacopoeia of India Part-1, Vol-1, 1st edition, Delhi: The Controller of Publications; 2008; Vol-4, p.124.
Ayurvedic Pharmacopoeia of India Part-1, Vol-1, 1st edition, Delhi: The Controller of Publications; 2008; Vol-4, p.134.
Ayurvedic Pharmacopoeia of India Part-1, Vol-1, 1st edition, Delhi: The Controller of Publications; 2008; Vol-5; p.193.
Tamhankar Y.,Bhadlikar D.,Mehta M., Screening of Immunomodulatory effect of Shataputi Abhrak Bhasma :Ayurveda's Rasayan; Ijapr November2015, Vol 3, Issue 11
Potbhare M., Khobragad D., In Vitro Evaluation of Antioxidant Potential of Ayurvedic Preparations Lauha Bhasma and Mandura Bhasma, Asian J. Pharm. Res. 2017; 7(2): 63-66.
Dr. Ullaguddi S. Screening of free radical scavenging activity and immune-modulatory effect of Vanga Bhasma;Rajiv Gandhi University of Health Sciences, Karnataka;2010
Kori M. L., Gaur K., Dixit V. K. Investigation of immunomodulatory potential of Cleome gynandra Linn.March 2009 Asian Journal of Pharmaceutical and Clinical Research 2 (1):35-39
Agarwal R, Diwanay S,Patki P, Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation Journal of Ethnopharmacology Volume 67, Issue 1,Oct1999, p.27-35
Gautam M., Saha S., Bani S., Immunomodulatory activity of Asparagus racemosus on systemic Th1/Th2 immunity: Implications for immunoadjuvant potential Dec2008; Journal of Ethnopharmacology 121(2):241-7
Rathod D.,Lahiri S., Yadav G., Immunomodulatory and antioxidant activity of Curculigo orchioides Gaertn April 2010 International Journal of PharmTech Research 2(2): 1197-1203
Patel J.,Doshi N.,Bhalerao A., Immunomodulatory activity of ethanolic extract of Pueraria Tuberosa D.C International Journal of Scientific & Engineering Research, Volume 7, Issue 11, November-2016 ISSN 2229-5518.
Kumar D., Arya V., Kaur R., A review of immunomodulators in the Indian traditional health care system, Journal of microbiology, Immunology &Infection 2012-45, 168-184
Journal of Ayurveda and Integrated Medical Sciences (JAIMS) retains the copyright of the contents of this journal but grant the readers the right to use the contents with terms and conditions under a creative common attribution licenses 4 of Attribution, Share Alike and Non-commercial type (CC BY-NC-SA) that allows copy, distribute, display, and perform the work and make derivative works based on it only for non-commercial purposes.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
