Sushruta’s eight pearls for Infective Ulcer
Abstract
A detailed review of ancient texts of Ayurveda connotes tremendous information on wound healing potentials of herbs being utilized by their different forms. This brings curiosity to learn more about the creative applications of herbs in various types of wounds. Probably this could be one among the several reasons which honors Sushruta, an Ancient Indian Surgeon as Father of Surgery. Wound dressing in various systems were compared not only on the basis of the rate of granulation tissue formed or the rate of wound healing but, also on the cost and duration of hospital stay of the patient which was considered as a measure of the morbidity of the patient. As per Ayurvedic texts, Wounds, Ulcers, Burns and Incision all are grouped under one term as ‘Vrana’, a defect in skin or mucous membrane being common in all of them. On the basis of stages of pathogenesis Vrana or ulcer has been divided as Dushta Vrana (Chronic / non healing / infected ulcer), Shuddhavrana (healthy wound), Ruhyamana Vrana (Healing wound) and Rudha Vrana (completely healed wound). Sushruta indicates eight pearls for Infective ulcer, these eight being the eight forms of medical therapeutics used locally to cleanse the ulcer and bring to healthy state.
Downloads
References
Bhishagratna KL, editor. An English translation of the Sushruta Samhita based on original Sanskrit text. Published by SL Bhaduri; 1916.Vol 2.p.284.
Sushruta, Sushruta Samhita, Ayurveda Tatwa Sandeepika Hindi Commentary, Edited by Kaviraj Ambika Dutta Shastri, Chikitsa Sthana Dvivranayee Adhyaya – 1/9, Chaukhambha Sanskrit Sansthan, Varanasi, Edition -11, 1997, p 5.
Sathish HS, Dudhamal TS, Gupta SK, Bhuyan C, Baghel MS. Overview of Academic Researches on Vranaropan (Tissue Healing) Properties of Ayurvedic Drugs. Indian Journal of Ancient Medicine and Yoga. 2014 Jan 1;7(1):33-47.
Sushruta Samhita of Maharshi – Sushruta Part -1, edited with Ayurveda-Tattva-Sandipika, commentary by Kaviraja Ambikadutta Shastri, Varanasi, Chaukhambha Sanskrit Sansthan, Chapter 22, shlok 7, Reprint:2007;p95.
Shekhar B Patil: Shodhana Effect of Panchavalkala Kvatha Prakshalana In the Management Of Pittaja Dushta Vrana. International Ayurvedic Medical Journal {online} 2017 {cited February, 2017} Available From: http://www.iamj.in/posts/images/upload/316_322.p df
Kumar SP, Smriti S, Kumar SA, Dwivedi KN. The impact of various Indian medicinal plants as a wounds healer. International Journal of Ayurveda and Pharma Research. 2015 Dec 14;3(1).
Bhat KS, Vishwesh BN, Sahu M, Shukla VK. A clinical study on the efficacy of Panchavalkala cream in Vrana Shodhana wsr to its action on microbial load and wound infection. Ayu. 2014 Apr;35(2):135.
Bhat, K. S., Vishwesh, B. N., Sahu, M., & Shukla, V. K. (2014). A clinical study on the efficacy of Panchavalkala cream in Vrana Shodhana w.s.r to its action on microbial load and wound infection. Ayu, 35(2), 135–140. http://doi.org/10.4103/0974-8520.146216
Kumar SA, Kumar SP, Kumar SV. Evaluation of Nimba Taila and Manjistha Churna in Non Healing Ulcer. IRJP. 2011;2(5):201-10.
Bhishagratna KL, editor. An English translation of the Sushruta Samhita based on original Sanskrit text. Wilkin's Press; 1907. Vol 2 p 284.
Howell JM, Chisholm CD (1992) Outpatient wound preparation and care: a national survey. Ann Emerg Med 21(8):976–981
Bhishagratna KL, editor. An English translation of the Sushruta Samhita based on original Sanskrit text. Wilkin's Press; 1907. Vol 2 p 285.
Sathish HS, Dudhamal TS, Gupta SK, Bhuyan C, Baghel MS. Overview of Academic Researches on Vranaropan (Tissue Healing) Properties of Ayurvedic Drugs. Indian Journal of Ancient Medicine and Yoga. 2014 Jan 1;7(1):33-47.
Bhishagratna KL, editor. An English translation of the Sushruta Samhita based on original Sanskrit text. Wilkin's Press; 1907. Vol 2 p 293.
Agnivesha, Charaka Samhita, Revised by Charaka and Dridabala with Ayurveda Deepika Commentary of Chakrapanidatta, Edited by Vaidya Jadavji Trikamji, Varanasi; Chowkambha Sanskrit Samsthana – 4 thEdition. 2001, T.pg: 73
Thakur R, Jain N, Pathak R, Sandhu SS. Practices in wound healing studies of plants. Evidence-based complementary and alternative medicine. 2011 May 26;2011.
S. Shetty, S. Udupa, and L. Udupa, “Evaluation of antioxidant and wound healing effects of alcoholic and aqueous extract of Ocimum sanctum Linn in rats,” Evidence-Based Complementary and Alternative Medicine, vol. 5, no. 1, pp. 95–101, 2008.
Tandon S, Rane S. Decoction and hot continuous extraction techniques. Extraction Technologies for Medicinal and Aromatic Plants. 2008:93.
Dire DJ: A comparison of wound irrigation solutions used in the emergency department. Ann Emerg Med 1990
Moscati: Comparison of normal saline with tap water for wound irrigation. Am J Emerg Med 1998.
Tripathy, Otta SP, Siddram. Indian Journal of Traditional Knowledge. Vol.10 (4), October 2011, pp.643-650.
Svoboda SJ, Bice TG, Gooden HA, Brooks DE, Thomas DB, and Wenke JC: Comparison of bulb syringe and pulsed lavage irrigation with use of a bioluminescent musculoskeletal wound model. J Bone Joint Surg Am 2006; 88: 2167.
Melling A, Whetter D, Leaper D. The Impact of localized warming on postoperative pain and wound healing after hernia surgery. EWMA 17/09/2005.
Joshua S Boateng et al, Wound Healing Dressings and Drug Delivery Systems – A review. Wiley InterScience :2007.
Shekhar B Patil: Shodhana Effect of Panchavalkala Kvatha Prakshalana In the Management Of Pittaja Dushta Vrana. International Ayurvedic Medical Journal {online} 2017 {cited February, 2017} Available from: http://www.iamj.in/posts/images/upload/316_322.pdf
Sonekar A, More YB, Sonekar R. Clinical evaluation of panchavalkal kashay dhavan In the management of diabetic wound. Ayurline: International Journal of Research In Indian Medicine. 2017 Aug 12;1(01):1-6.
Vyas M, Patgiri BJ, Prajapati PK. Classical and contemporary contrive of Varti Kalpana. International Journal of Ayurvedic Medicine. 2012 Mar 9;2(4).
Bhishagratna KL, editor. An English translation of the Sushruta Samhita based on original Sanskrit text. Wilkin's Press; 1907. Vol 2 p 293.
Ruchi Pandey & Tukaram S. Dudhamal: Role Of Ksharasutra And Kasisadi Ghrita In The Management Of Stanagat Nadivrana (Tubercular Multiple Breast Sinuses) -A Rare Case Report. International Ayurvedic Medical Journal {online} 2017 {cited July, 2017} Available from: http://www.iamj.in/posts/images/upload/2711_2718. pdf
Patil S. Topical dosages forms (Lepa Kalpana) of Ayurveda: An unexplored treasure. International Journal of Green Pharmacy (IJGP). 2016 Feb 5;9(4).
Sushruta, Sushrata Samhita, Chikitsa Sthana, Vranachikitsa Adhaya 1 edited with Ayurveda Sandipika Hindi Commentary by Kaviraj Ambikadutta Shastri. Varanasi: Chaukhambha Sanskrita Sanstana;1997.
Bhishagratna KL, editor. An English translation of the Sushruta Samhita based on original Sanskrit text. Wilkin's Press; 1907. Vol 1 p 157.
Kulkarni DV. Treatment of Dushta Vrana by Tila Kalka, Madhu and Ghruta. International Journal of AYUSH. 2015 Dec 31;4(3):144-6.
Ajmeer AS, Dudhamal TS, Gupta SK. Management of Madhumehajanya Vrana (diabetic wound) with Katupila (Securinega leucopyrus [Willd] Muell.) Kalka. Ayu. 2015 Jul;36(3):351.
Wound healing activity of Topical application forms based on Ayurveda, Hema Sharma Datta, Shankar Kumar Mitra, Bhushan Patwardhan, Evidence based complementary and Alternative Medicine, Volume 2011,Article ID 134378
Bhishagratna KL, editor. An English translation of the Sushruta Samhita based on original Sanskrit text. Wilkin's Press; 1907. Vol 2 p 293.
Choudhary N, Soni P, Narode S, Swarnkar M. A Randomized Controlled Clinical Study of Karanjadhya Ghrita on Acute Wounds with special reference to its Wound Healing Properties. International Journal of Ayurveda and Pharma Research. 2015 Dec 14;3(4).
Kumar Mahesh. Jatyadi ghrita and its used in treating vrana (wound). Int. Res. J. Pharm. 2014; 5(3): 128-130 http://dx.doi.org/10.7897/2230-8407.050327
Nikam ST. Study of Karpoor Ghrita and Povidine Iodine in Sadyo Vrana. International Journal of Ayurvedic Medicine. 2015 Dec 29;6(4).
Shiralkar MV, Shiralkar DM, Krushnadev S, Tamhane V, Wagh R. To Evaluate the Effect of Yashti-Madhu-Ghrita application in Post-Operative Management of Agnidagdha Vrana in Arshas. AYUSHDHARA. 2016 Feb 3;2(5).
Baria J, Gupta SK, Bhuyan C. Clinical study of Manjishthadi Ghrita in vrana ropana. Ayu. 2011 Jan;32(1):95.
Supriya deshpande, Avinash deshpande, Suresh tupkari, Anoop Agnihotri, shata-dhauta ghrita-A case study, Indian journal of traditional knowledge, vol8(3), july2009, page no.387- 391.
Rai P. Role Of Murchhana Samskara In The Preparation Of Medicated Ghrita WSR To Panchtikta Ghrita. IAMJ,2015;3(8).
Dhruve K, Chaudhary A. Sneha kalpana- A probable pharmaceutical explanation. Aryvaidyan. 2007;20:181– 9.
Savrikar S, Ravishankar B. Introduction to ‘Rasashaastra’-The Iatrochemistry of Ayurveda. African Journal of Traditional, Complementary and Alternative Medicines. 2011;8(5S).
Pallavi Srivastava, Durgaprasad S. Wound Healing property of Cocos nucifera: An appraisal. Indian J pharmacol; Aug 2008: 40(4): 144-146.
Bhishagratna KL, editor. An English translation of the Sushruta Samhita based on original Sanskrit text. Wilkin's Press; 1907. Vol 2 p.294.
Li ZQ, Wang JH, Ren JL, Yi ZH. Effects of topical emu oil on wound healing in scalded rats. Di 1 jun yi da xue xue bao= Academic journal of the first medical college of PLA. 2004 Nov;24(11):1255-6.
Goli PP, Krishna CM, Kumar SP, Tirumal G, Narayana A. Effect of Dvi-Avartita Bhringaraja Taila in Dushtha Vrana (Chronic Infected Ulcer). International Journal of Ayurvedic Medicine. 2010 Jun 30;1(1).
Li HL, Chen LP, Hu YH, Qin Y, Liang G, Xiong YX, Chen QX. Crocodile oil enhances cutaneous burn wound healing and reduces scar formation in rats. Academic emergency medicine. 2012 Mar 1;19(3):265-73.
Dursun N, Liman N, Özyazgan I, Günes I, Saraymen R. Role of thymus oil in burn wound healing. Journal of Burn Care & Research. 2003 Nov 1;24(6):395-9.
Tilak, P.K., Arawatti, S. and Swapna, B., 2012. A clinical study in the management of sadyovrana with Bala taila parisheka: 04, Abstracts of Pandit G.P. Wickramarachchi Memorial Research Symposium. 7th- 9th November 2012, Gampaha Wickramarachchi Ayurveda Institute, University of Kelaniya, Yakkala, Sri Lanka.
Koh, K.J.; Pearce, A.L.; Marshman, G.; Finlay-Jones, J.J.; Hart, P.H. Tea tree oil reduces histamine-induced skin inflammation. Br. J. Dermatol. 2002, 147, 1212–1217.
Oommen, Shanthakumar Thomas; Rao, Mallikarjun; Chintalapati Venkata Narashima Raju. International Journal of Leprosy and Other Mycobacterial Diseases; Lawrence 67.2 (Jun 1999): 154-8.
Kumar SA, Kumar SP, Kumar SV. Evaluation of Nimba Taila and Manjistha Churna in Non Healing Ulcer. IRJP. 2011;2(5):201-10.
Gupta Sudesh, Bhat Subrahmanya S, Nayak Jaykrishna. A clinical study to evaluate efficacy of Nimbaadya taila in the management of Dusta Vrana [Chronic Ulcer]. Int. J. Res. Ayur. Pharm. 2012; 3(6):862-865
Olajuyigbe, O.; Ashafa, A. Chemical Composition and Antibacterial Activity of Essential Oil of Cosmos bipinnatus Cav. Leaves from South Africa. Iran. J. Pharm. Res. IJPR 2014, 13, 1417–1423.
Hammer, K.A.; Carson, C.F.; Riley, T.V. Effects of Melaleuca alternifolia (tea tree) essential oil and the major monoterpene component terpinen-4-ol on the development of single- and multistep antibiotic resistance and antimicrobial susceptibility. Antimicrob. Agents Chemother. 2012, 56, 909–915.
Blackwood, B.; Thompson, G.; McMullan, R.; Stevenson, M.; Riley, T.V.; Alderdice, F.A.; Trinder, T.J.; Lavery, G.G.; McAuley, D.F. Tea tree oil (5%) body wash versus standard care (Johnson’s Baby Softwash) to prevent colonization with methicillin-resistant staphylococcus aureus in critically ill adults: A randomized controlled trial. J. Antimicrob. Chemother. 2013, 68, 1193–1199.
Liakos, I.; Rizzello, L.; Hajiali, H.; Brunetti, V.; Carzino, R.; Pompa, P.P.; Athanassiou, A.; Mele, E. Fibrous wound dressings encapsulating essential oils as natural antimicrobial agents. J. Mater. Chem. B 2015, 3, 1583– 1589.
Khajavi, R.; Abbasipour, M.; Barzi, M.G.; Rashidi, A.; Rahimi, M.K.; Mirzababa, H.H. Eucalyptus essential oildoped alginate fibers as a potent antibacterial wound dressing. Adv. Polym. Technol. 2014, 33.
Deevi VR. An Enlightenment on Rasakriya Kalpana. International Journal of Ayurvedic Medicine. 2010 Oct 10;1(2).
Sushrutacharya, Sushruta Samhita with Nibandhasangraha commentary by Dalhanacharya and Nyayachandrika Panjika of Gayadasacharyaa, Edited by Yadavaji Trikamaji Acharya, and Narayana Ram Acharya Kavyatirtha, Reprint Edition 2008, Chaukhamba Surbharati Prakashana, Varanasi, Sutrasthana – 37/20.
Katiyar CK. 6 Aqueous Alcoholic Extraction of Medicinal and Aromatic Plants by Fermentation. Extraction Technologies for Medicinal and Aromatic Plants. 2008:107.
Bhishagratna KL, editor. An English translation of the Sushruta Samhita based on original Sanskrit text. Wilkin's Press; 1907. Vol 2 p 294.
Vishwakarma N, Nagamani D. Clinical study on the effect of Dwiharidra rasakriya pichu in the management of Parikartika (Fissure in ano). International Journal of Ayurvedic Medicine. 2016 Sep 25;7(3).
Kumar S, Sahu S, Sanjay KS. An Experimental Evaluation on Wound Healing Property of Shigru Patra Ghanasatva (Leaf water extract of Moringa oleifera Lam). Journal of Ayurveda Physicians & Surgeons (JAPS)(EISSN 2394- 6350). 2017 May 18;3(3).
Bhishagratna KL, editor. An English translation of the Sushruta Samhita based on original Sanskrit text. Wilkin's Press; 1907. Vol 2 p 294.
Vijakumar B, Prasanna NR, Hemantkumar P. A Comparative Study of Kaseesadi Avachurnana and Jatyadi Ghrita Application in the Management of Dushta Vrana. International Journal of Research in Ayurveda & Pharmacy. 2012 Nov 1;3(5).
Rupapara AV, Donga SB, Dei LP. Review of Clinical Studies on Cervical Erosion (Garbhashaya Grivamukhagata Vrana). IAMJ: Volume 3; Issue 4; April 2015
Shirke A. Management of Garbhasaya Greevagata Vrana (Cervical Ectopy) with Tankana Jala Yoni Dhavana and Aswattha Churna Orally (Under VIA And VILI). International Journal of Ayurvedic Medicine. 2017 Mar 26;8(1).
Maurya M, Maurya DK. Vranaropaka effect of Laksha Churna with Madhu on wound after removal of Danta Sharkara. Ayu. 2012 Jan;33(1):92.
Sangu PK, Sharma BK, Ala N. International Journal Of Ayurvedic And Herbal Medicine 2: 3 (2012) 530: 540. 74. Dudhamal TS. Wound healing activity of Arjuna bark powder in Dushta vrana (Non healing venous ulcers)-A Case Report. Journal of Ayurvedic and Herbal Medicine. 2016;2(4):102-3.
Karunarathna HM, NWGND G. Medical formulas for Krimidanta (Dental Caries) in Indigenous Medicine In Sri Lanka–A Literary Review. International Journal of Ayurveda and Pharma Research. 2016 Oct 2;4(9).
Bhinde S, Joshi S. Dhupakalpadhyaya of Kashyapa Samhita. Journal of Indian System of Medicine.:82.
Mishra DP. A bird eye view on Rakshakarma in Ayurveda. IAMJ: Volume 3; Issue 6; June -2015 78. Katiyar CK. 6 Aqueous Alcoholic Extraction of Medicinal and Aromatic Plants by Fermentation. Extraction Technologies for Medicinal and Aromatic Plants. 2008:107.
Vijayan A. A Comparative Study of the Wet and Dry Forms of Bacopa Monnieri (Linn) and Centella Asiatica (Urban) wsr to Anti-Stress and Anti-Convulsant Effect in Albino Rats (Doctoral dissertation).
Kumar S. Preventive Measures for a Healthy Progeny and Child in Pediatrics Practices. AYUSHDHARA. 2017 Jan 11;3(3).
Bhishagratna KL, editor. An English translation of the Sushruta Samhita based on original Sanskrit text. Wilkin's Press; 1907. Vol 2 p 298.
Ahamad A, Singh S. Management of Dushta Vrana (Non-Healing Ulcer) by Dhoopana (fumigation) with Guggulu Panchapala Choorna–A Case Report. Journal of Ayurveda and Integrated Medical Sciences (ISSN 2456-3110). 2016 Jul 8;1(1):95-7.
Sumitha L, Prasad BS. Evaluation of Antimicrobial and Antifungal Property of Dhoopana Karma (Fumigation)- By" Dhup" An Ayurvedic Dhoopana Product. International Journal of Pharmaceutical Sciences and Research. 2015 Jul 1;6(7):2950.
China Papers, (2010). Wound Healing on the 1st Fumigation on the Mixed Hemorrhoid Complications of Postoperative Wound Healing and Postoperative Pain Edema. http://mt.china-papers.com/2/?p=38390
Shanti V. Sthanika chikitsa in Yonivyapada, Yoni Dhupana, Ayurvedline, Published by Dr. Seetharam Prasad, Bangalore,. 2012;150.
Mahajan DH, Chaudhary SS. A critical review on Sthanik Chikitsa (local therapies) Adopted in Stree Roga. International Journal. 2014;2(3).
Jason H, Calhoun MD et al. Diabetic Foot ulcers and Infections: Current Concepts. Advances in Skin & Wound Care; January/February 2002.p.33.
Willi Paul, Chandra P Sharma. Chitosan and Alginate wound dressings: A Short Review. Trends Biomater. Artif. Organs, Vol 18 [1], pp 18-23 [2004].
Sussman G. Management of the Wound environment. In: Sussman C, Bates-Jensen BM, eds. Wound Care: A Collaborative Practice Manual for Physical Therapists and Nurses. Gaithersburg, MD: Aspen Publishers, Inc; 1998: p 201-13.
Thom R M S, Greenman J, et al. [2005]. In vitro method to assess the antimicrobial activity and potential efficacy of novel types of wound dressings. Journal of Applied Microbiology. 99:895-901.
Falanga V. Classification for wound bed preparation and Stimulation of Chronic wounds. Wound Repair and Regeneration 2000; 8: 347-352.
Sibbald RG, Williamson D, Orstedt HL, Cambell K, Keast D, Krasner D, Sibbald D. Preparing the Wound Bed – Debridement, Bacterial Balance, and Moisture Balance. Ostomy Wound Management 2000; 46: 14-35.
Sleggreen M, Malkebust J. Debridement: choices and challenges. Advances in wound care. 11997;10[2]:32- 37.
Journal of Ayurveda and Integrated Medical Sciences (JAIMS) retains the copyright of the contents of this journal but grant the readers the right to use the contents with terms and conditions under a creative common attribution licenses 4 of Attribution, Share Alike and Non-commercial type (CC BY-NC-SA) that allows copy, distribute, display, and perform the work and make derivative works based on it only for non-commercial purposes.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.