Geographical variation in Chemo profile, Genetic profile and In-vitro Anticancer activity of Chitraka (Plumbago zeylanica Linn.) collected from Himalayas and Western Ghats
Abstract
Therapeutic actions of medicinal plants are due to the chemical components present in them. These chemical constituents often vary with change in geographical and climatic conditions. Climate, altitude, and temperature play an important role to make a herb therapeutically potent. Ancient Ayurvedic physicians mentioned that medicinal plants which grow in Himalayan region are more potent as compared to the plants growing in other regions. A modest study was therefore undertaken to compare the in vitro anticancer activity of Plumbago zeylanica Linn. collected from Himalayan region and Western Ghats with respect to their chemo profile and genetic patterns. Variation in physio-chemical, phyto-chemical, the genetic profiles were observed in plants collected from these two regions and corresponding variation was also seen in their anticancer activities.
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Huiling Yang, Chenxu Ding, Yuanwen Duan, Jianquan Liu∗ Variation of active constituents of an important Tibet folk medicine Swertiamussotii Franch. (Gentianaceae) between artificially cultivated and naturally distributed. Journal of Ethnopharmacology,2005,98: 31- 35.
P. Pushpangadan. Important Indian Medicinal plants of Global Interest in Ayurveda and its scientific aspects: Opportunities for Globalisation, International Conclave traditional Medicine, (Department of AYUSH and NISCAIR,CSIR Delhi,2006,pp287-298.
Charaka Samhita, Vaidya Manorama Hindi Commentary By Acharya Vidyadhar Sukla an Prof. Ravi Dutt Tripathi , Part-I, Chaukambha Sanskrit Pratishthan, Delhi, 2002 Reprint, Sutra Sthana 25th Chapter 40thShlokaPp 337-342.
Charaka Samhita, Charaka Chandrika Hindi Commentary By Bramhananad Tripathi, Part-II, Chaukambha Surbharti Prakashan, Varanasi , 2003 Reprint, Cikitsasthana, 1/38 p.no.742.
Charaka Samhita, Charaka Chandrika Hindi Commentary By Bramhananad Tripathi, Part-II, Chaukambha Surbharti Prakashan, Varanasi , 2003 Reprint, Kalpasthana, 1st Chapter, 10th Shloka, pp.1077
Sarangadhar Samhita, Jiwanprada Hindi Commentary, By Dr. Smt Shailaja Srivastava, First edition 1984, published by Choukhambha Orientalia, Varanasi, 1998 Reprint, Purva Khanda chapter 1st 57th Shloka pp. 13.
Doyle J.J 1991 D.N.A protocols for plants pp.283-293 in G.Hewitt A. W.B Jhonson and J.P.W Young (eds.) molecular techniques in taxonomy NATC A S I Series H cell biology vol.57
Williams JG, Kubelik A R, Livak K J, RafalskiJA, TingeySV; D N A Polymorphisms amplified by arbitrary primers are useful as genetic markars. Nucleic acid res 1990 Nov.25; 18(22); 6531 -5
Skehan P., Storeng R., Scudiero D., Monks A., McMahon J., Vistica D., Warren J. T., Bokesch H., Kenney S. and Boyd M. R.; New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening J. Natl. Cancer Inst, 82 : 1107 1990
A.K. Gupta ,Neeraj Tandon, Quality Standard of Indian Medicinal Plants, vol.7, Indian Council of Medical Research, New Delhi, p.no.69.
Vineet Mittal, SK Sharma, Deepak Kaushik, Meenu Khatri and Kusum Tomar, Research Journal of Pharmaceutical, Biological and Chemical Sciences, October - December 2010 RJPBCS 1(4) Page No. 830- 836
Perchellet JP, Gali HU, Perchellet EM, Klish DS, Armburst, Antitumor-promoting activities of tannic acid, ellagic acid, and several gallic acid derivatives in mouse skin, Basic Life Sci. 1992;59:783-801
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