In Vivo Anti-Cancer studies of Simarouba glauca aqueous extract leaves on Ehrlich Ascites Carcinoma model in mice

Mahesh CD; Subramanya Padyanna; Manjunath; Suresh Janadri

Mahesh CD Ph.D Scholar, Dept. of Dravya Guna, Sri Sri College of Ayurvedic Science and Research, Bangalore, Karnataka, India.
Subramanya Padyanna Professor & HOD, Dept. of Dravya Guna, Alvas College of Ayurvedic Science and Research, Moodabidri, Karnataka, India.
Manjunath 3Professor & HOD, Dept. of Pharmacology, Acharya & BM Reddy College of Pharmacy, Bangalore, Karnataka, India.
Suresh Janadri Associate Professor, Dept. of Pharmacology, Acharya & BM Reddy College of Pharmacy, Bangalore, Karnataka, India.

Keywords: Simarouba glauca aqueous extract leaves, Ehrlich's ascites carcinoma, Anticancer, 5-Fluorouracil.

Abstract

The present study has been carried out to explore the in vivo anticancer activity of Simarouba glauca aqueous extract leaves against Ehrlich Ascites Carcinoma (EAC) in Swiss albino mice.The in vivo anticancer activity has been evaluated against EAC cells in Swiss albino mice by monitoring parameters including body weight, mean survival time and hematological parameters. This study indicated that aqueous extract of S. glauca DC leaves (500 mg/kg, p.o.) that significantly increase life span, compared to control group. 5-Flurouracil (20mg/kg, p.o.) was used as a positive control. Simarouba glauca DC leaves (500 mg/kg, p.o.) alerted the hematological parameters such as hemoglobin content increased, RBC increased and WBC decreases compared to cancer control. In conclusion, S.glauca DC leaves (500 mg/kg, p.o.) shows anticancer activity in EAC induced carcinoma in mice.

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