A Clinical Study on the Effect of Ashwagandhadi Churna in the management of Rakta-Gata-Vata with special reference to Essential Hypertension

Abstract

Introduction: Hypertension is an important public health challenge worldwide and remains as major cause of morbidity and mortality. Hypertension is the third most important attributable risk factor for burden of disease in South Asia (2010). In India, Hypertension is the leading cause of premature death. Hypertension is directly responsible for 29% of all stroke and 24% of heart attack in India. Objectives: To Evaluate the effect of Ashwagandhadi Churna in the management of Rakta-Gata-Vata (Essential hypertension). Materials and Methods: 40 clinically diagnosed patients of Essential Hypertension were selected based on inclusion criteria. Selected patients were randomly divided into two groups: Group A (Trial) was given Ashwagandhadi Churna in a dose of 3gms twice daily and Group B was given Sarpagandha Churna in a dose of 1gms twice daily with water for 21 days. The data was graded based on assessment criteria and was analysed statistically. Results: Outcome of the treatment after 21 days was statistically significant in most of the sign and symptom score of various subjective and objective parameters. Overall it shows statistically significant result. Discussion: The total mean of SBP, DBP, PP and MAP before treatment was 160.10, 91.4, 65.30, 114.25 respectively after 21 days of therapy the total mean of SDP, DBP, MAP, and PP are 134.60, 82.60, 51.00, 98.75 respectively and all showed statistically significant at 0.01 except DBP which showed statistically insignificant. The mean of total cholesterol, triglycerides, low density lipoproteins and High density lipoproteins before treatments are 199.85, 132.05, 116.25, and 44.90 after 21 days of therapy the total mean of total cholesterol, triglycerides, low density lipoproteins and High density lipoproteins are 189.60, 124.60, 109.25, 49.10 respectively and showing statistically significant at 0.01. Ashwagandhadi Churna is found to be effective in mild and moderate HTN and also on reducing cholesterol level (T.cho, TGL, and LDL) and slightly increases HDL level.