An in vivo study to evaluate the antipyretic activity of Suryaprabha Gulika in brewer’s yeast induced pyrexia in wistar albino rats

Abstract

Introduction: Suryaprabha Gulika is one of the Rasayoga, mentioned in Sahasrayogam Gulika Prakarana, prepared by Khalviya method of preparation. The formulation is widely practiced clinically and prescribed in conditions of fever associated with Svasa and Kasa. In the present scenario, validation of any classical concept has emerged to be essential for acceptance by the scientific community. Since antipyretic activity could be elicited in animal models, the present study aims at eliciting the antipyretic activity of Suryaprabha Gulika in wistar albino rats using brewer’s yeast induced pyrexia method. Materials and methods: Suryaprabha Gulika was prepared as per the classical reference text, Sahasrayogam. Qualitative and quantitative assessment of the prepared drug was carried out. The experimental study to evaluate the antipyretic activity of the formulation was screened using brewer’s yeast induced pyrexia method. Statistical test used for evaluation was one way ANOVA followed by Dunett’s multiple comparison ‘t’ test as post- Hoc test, if p<0.05 was considered significant, using graphpad instat software. Results: When compared to the control group, Suryaprabha Gulika was found to be effective in bringing about antipyretic action. It also had almost similar efficacy as that of standard drug in bringing about antipyretic action in experimental models. Discussion: The antipyretic study of Suryaprabha Gulika in wistar albino rats brought out that the drug possesses highly significant antipyretic action.