Immunomodulatory activity of Mashaparni - Teramnus labialis Spreng

Dr. Shweta; Dr. Seema Pradeep; Dr. Shiva Manjunath M.P

doi:10.21760/jaims.v4i06.755

Dr. Shweta Post Graduate Scholar, Dept. of Dravyaguna, Sri Sri College of Ayurvedic Science and Research Bangalore, Karnataka, INDIA.
Dr. Seema Pradeep Professor & HOD, Dept. of Dravyaguna, Sri Sri College of Ayurvedic Science and Research Bangalore, Karnataka, INDIA.
Dr. Shiva Manjunath M.P Botanist, Sri Sri College of Ayurvedic Science and Research Bangalore, Karnataka, INDIA.

DOI: https://doi.org/10.21760/jaims.v4i06.755

Keywords: Mashaparni, Guduchi, Extract, Antigen, Digital Plethysmograph

Abstract

Background: Mashaparni is a plant belonging to the family Fabaceae and used in ayurvedic system of medicine and is being used in diet by various people of India and it also forms a part of traditional Indian cuisine. Teramnus labialis Spreng as accepted botanical source of Mashaparni. Mashaparni is widely used as Balya drug as mentioned by Charaka acharya in Balyamahakashaya gana. Hence this study is aimed to evaluate the Immunomodulatory activity of Mashaparni. Methodology: Experimental studies to determine the Immunomodulatory activity of Mashaparni Teramnus labialis Spreng by antigen induced rat paw oedema in Wister albino rats and the drug in the Aqueous & Ethyl extract form respectively. The studies were carried out on 4 groups i.e. Control group, Standard group, Aqueous extract and Ethyl extract form. Standard drug taken for the study is Guduchi Tinospora cordifolia in Ethyl extract form. Immunomodulatory activity determined by Delayed Type Hypersensitivity method with the help of Digital Plethysmograph method for duration of 15 days. The rat paw volume was the assessment parameter and the results were recorded at 2nd, 4th, 6th, & 24th hours after induction of antigen. Results: The Aqueous extract of Mashaparni shows a significant Immunomodulatory action compared to Ethyl extract of Mashaparni.

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